Evaluation of Bone Turnover in Patients With Type 1 Diabetes Mellitus

Safarova, S. S.

doi:10.14740/jem483w

Cited by 1 publication

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If in general, the processes of bone formation and resorption are closely related, and formation markers and resorption markers tend to change in a coordinated manner, then in patients with diabetes observed dissociation of these processes, while formation markers are reduced, and found no changes in bone resorption markers. Data from a number of researchers also indicate a moderate decrease in bone formation markers in diabetes, accompanied by normal levels of bone resorption markers in most studies ( 6 , 7 ). Markers of bone metabolism indicate very specific changes in bone remodeling processes associated with a disruption in the metabolism of carbohydrates in diabetes, when the formation markers are reduced, while the resorption markers do not change, apparently due to hyperglycemia-induced inhibition of osteoblastic function ( 8 ).…”

Section: Discussionmentioning

confidence: 90%

“…Markers of bone metabolism indicate very specific changes in bone remodeling processes associated with a disruption in the metabolism of carbohydrates in diabetes, when the formation markers are reduced, while the resorption markers do not change, apparently due to hyperglycemia-induced inhibition of osteoblastic function ( 8 ). It is possible that blood glucose concentration changes may affect the circulating concentrations of these bone metabolic markers ( 7 , 9 ), which can clinically increase the bone fragility in patients with diabetes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bone Metabolism Parameters in Azerbaijani Pre and Postmenopausal Women with Diabetes

Safarova¹

2023

ijph

View full text Add to dashboard Cite

Background: This study aimed to determine the directionality of changes in serum bone remodeling markers and bone mineral density in the pre- and postmenopausal women with diabetes mellitus. Methods: This study was carried out during the years 2016–2017 on the basis of Azerbaijan Medical University and included 142 pre- and postmenopausal women with type 1 and 2 diabetes mellitus (DM 1and DM2) were compared with 43 age-matched non-diabetics. The groups evaluated Ca2+, PTH, CT, 25(OH)D levels, serum bone remodeling markers (ALP, P1NP, b-CTx), lumbar spine, proximal and femoral neck areas using DXA assessment. Results: The results showed inconsistency observed between bone remodeling processes in women with diabetes. A negative correlation was observed between duration of diabetes and Lumbar T-scores (DM1: r = -0.568, P = 0.001; DM2: r = -0.267, P = 0.04). Lumbar T-scores was negatively correlated with b-CTx level (DM1: r = -0.452, P = 0.002; DM2: r = -0.357, P = 0.09). Postmenopausal groups with DM1 and DM2 were slightly higher b-CTx levels than premenopausal. Conclusion: The patients with DM2 compared to DM1 had higher average BMD at all measured areas. Bone fragility is the result not so much of a decrease in BMD, but alterations in bone microstructure, as indicated by the disregulation of bone remodeling markers. This suggests that patients with diabetes are at a higher risk of bone turnover disorders compared to individuals without diabetes, which does not necessarily correlate with differences in BMD.

show abstract

Section: Discussionmentioning

confidence: 90%