Evaluation of Bone Mineral Status in Adolescent Idiopathic Scoliosis

Tahvildari, Babak Pourabbas; Erfani, Mohammad; Nouraei, Hasti; Sadeghian, Mohammad

doi:10.4055/cios.2014.6.2.180

Cited by 34 publications

(15 citation statements)

References 13 publications

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“…Moreover, not only idiopathic scoliosis patients but also congenital and neuromuscular scoliosis patients were included in the current study. A study by Tahvildari et al [19] reported low BMD in patients with adolescent idiopathic scoliosis by using DEXA. Sadat-Ali et al [4] compared BMD values in patients with adolescent idiopathic scoliosis and their healthy siblings by using DEXA, and they found lower BMD values in the scoliosis group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of vertebral bone mineral density in scoliosis by using quantitative computed tomography

Sarıoğlu¹,

Sarioglu²,

Köremezli³

et al. 2019

Pol J Radiol

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Purpose Scoliosis is described as a lateral curvature of the spine. We aimed to evaluate bone mineral density (BMD) in patients with scoliosis by using quantitative computed tomography (QCT) and compare the BMD of idiopathic and congenital scoliosis patients. Material and methods Forty-three patients aged 1 to 40 years with idiopathic, congenital, or neuromuscular scoliosis and 41 matched controls of the same sex and approximate age were included in the study. Measurements of BMD were performed by QCT analysis for each vertebral body from T12 to L5, and mean BMD was calculated for each case. Results Twenty-two of the patients with scoliosis were idiopathic, 15 were congenital, four were neuromuscular, and two were neurofibromatosis. The mean BMD values of patients with scoliosis were significantly lower compared with the control group (106.8 ± 33.4 mg/cm 3 vs. 124.9 ± 29.1 mg/cm 3 , p = 0.009). No significant difference in BMD values was found between idiopathic and congenital scoliosis patients ( p > 0.05). Conclusions This study illustrated that the vertebral body BMD values of the patients with scoliosis were significantly lower than those seen in the control group.

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Section: Discussionmentioning

confidence: 99%

Evaluation of vertebral bone mineral density in scoliosis by using quantitative computed tomography

Sarıoğlu¹,

Sarioglu²,

Köremezli³

et al. 2019

Pol J Radiol

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“…There are studies that also revealed an important association between scoliosis and osteopenia [12][13][14][15][16][17][18][19]. Other authors reported osteopenia as a cause of scoliosis worsening as it represents a risk of curve progression [20,21].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Static Plantar Pressure, Stabilometry, Vitamin D and Bone Mineral Density in Female Adolescents with Moderate Idiopathic Scoliosis

Căţan

Cerbu

Amăricăi

et al. 2020

IJERPH

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(1) Background: Adolescent idiopathic scoliosis (AIS) can be associated with vitamin D deficiency and osteopenia. Plantar pressure and stabilometry offer important information about posture. The objectives of our study were to compare static plantar pressure and stabilometric parameters, serum 25-OH-vitamin D3 and calcium levels, and bone mineral densitometry expressed as z-score in patients with moderate AIS and healthy subjects. (2) Methods: 32 female adolescents (idiopathic S shaped moderate scoliosis, main lumbar curve) and 32 gender and age-matched controls performed: static plantar pressure, stabilometry, serum 25-OH-vitamin D3 and calcium levels, and dual X-ray absorptiometry scans of the spine. (3) Results: In scoliosis patients, significant differences were recorded between right and left foot for total foot, first and fifth metatarsal, and heel loadings. Stabilometry showed a poorer postural control when compared to healthy subjects (p < 0.001). Patients had significantly lower vitamin D, calcium levels, and z-scores. Lumbar Cobb angle was significantly correlated with the z-score (r = −0.39, p = 0.02), with right foot fifth metatarsal load (r = −0.35, p = 0.04), center of pressure CoPx (r = −0.42, p = 0.01), CoP displacement (r = 0.35, p = 0.04) and 90% confidence ellipse area (r = −0.38, p = 0.03). (4) Conclusions: In our study including female adolescents with idiopathic S shaped moderate scoliosis, plantar pressure and stabilometric parameters were influenced by the main scoliotic curve.

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“…Since the Burner group first reported the association of low bone mineral density in AIS in 1982, scholars have focused on the relationship between osteopenia and AIS [6]. Most researchers have found that the incidence rate of osteopenia, which is the most common metabolic bone disease in adults but is rare in adolescents, is much higher in AIS than in adolescent populations, ranging from 20 to 38% [7, 8]. In addition, osteopenia is considered one of the causes of scoliosis curvature progression and curve severity [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway

et al. 2019

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Background Osteopenia have been well documented in adolescent idiopathic scoliosis (AIS). Adiponectin has been shown to be inversely proportional to body mass index and to affect bone metabolism. However, the circulating levels of adiponectin and the relationship between adiponectin and low bone mass in AIS remain unclear. Methods A total of 563 AIS and 281 age-matched controls were recruited for this study. Anthropometry and bone mass were measured in all participants. Plasma adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA) in the AIS and control groups. An improved multiplex ligation detection reaction was performed to study on single nucleotide polymorphism. Facet joints were collected and used to measure the microstructure, the expression of RANKL, OPG, osteoblast-related genes, inflammatory factors, adiponectin and its receptors by qPCR, western blotting and immunohistochemistry. Furthermore, primary cells were extracted from facet joints to observe the reaction after adiponectin stimulation. Results Compared with the controls, lower body mass index and a marked increase in circulating adiponectin were observed in AIS osteopenia (17.09 ± 1.09 kg/m 2 and 21.63 ± 10.30 mg/L). A significant difference in the presence of rs7639352 was detected in the AIS osteopenia, AIS normal bone mass and control groups. The T allele showed a significant higher proportion in AIS osteopenia than AIS normal bone mass and control groups (41.75% vs 31.3% vs 25.7%, p < 0.05). micro-CT demonstrated that the AIS convex side had a significant lower bone volume than concave side. RNA and protein analyses showed that in cancellous bone, higher RANKL/OPG and adipoR1 levels and lower runx2 levels were observed, and in cartilage, higher adipoR1 and IL6 levels were observed in AIS. Furthermore, convex side had higher RANKL/OPG, IL6 and adipoR1 than concave side. Compared with normal primary cells, convex side primary cells showed the most acute action, and concave side primary cells showed the second-most acute action when exposed under same adiponectin concentration gradient. Conclusion Our results indicated that high circulating adiponectin levels may result from gene variations in AIS osteopenia. Adiponectin has a negative effect on bone metabolism, and this negative effect might be mediated by the ADR1-RANKL/OPG and ADR1-IL6 pathways. Electronic supplementary material The online version of this article (10.1186/s12967-019-1805-7) contains supplementary material, which is available to authorized users.

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Evaluation of Bone Mineral Status in Adolescent Idiopathic Scoliosis

Cited by 34 publications

References 13 publications

Evaluation of vertebral bone mineral density in scoliosis by using quantitative computed tomography

Evaluation of vertebral bone mineral density in scoliosis by using quantitative computed tomography

Assessment of Static Plantar Pressure, Stabilometry, Vitamin D and Bone Mineral Density in Female Adolescents with Moderate Idiopathic Scoliosis

Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway

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