Evaluation of bone mineral density and 25-hydroxyvitamin D levels in subjects with silica exposure

Abstract

Objective The purpose of the study was to evaluate the bone mineral density (BMD) and 25-hydroxyvitamin D (25(OH)D) levels in patients with silica exposure. Materials and methods The study included 104 male subjects with silica exposure and 36 healthy subjects. Posterior-anterior radiographs were classified according to the International Labour Office (ILO) Classification. Category 0 patients were classified as Group I (n = 54), category I patients were classified as Group II (n = 25), Category II and III patients were classified as Group III (n = 25). Results Femoral neck BMD values were significantly lower in Group III (p = 0.007). Lumbar vertebrae BMD values were significantly lower in all groups with silica exposure than in the control group (p = 0.000). The osteoporosis rate was significantly higher in Group III (p = 0.000). Subjects with silica exposure were determined to have diminished 25(OH)D levels (p = 0.012). ConclusionThe results of this study demonstrated that subjects with silica exposure have diminished BMD and 25(OH)D levels.

The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings

“…In contrast, Si overexposure may have adverse effects on bone quality markers. Specifically, occupational Si exposure in Turkish stone carvers or quartz miners is associated with reduced 25-hydroxycalciferol levels and BMD [308], being in agreement with laboratory studies in a rat model of silicosis [309]. At the same time, increased intake of Si with artesian drinking water for 12 weeks was not associated with alterations in bone resorption [310].…”

Ac-SDKP Attenuates Activation of Lung Macrophages and Bone Osteoclasts in Rats Exposed to Silica by Inhibition of TLR4 and RANKL Signaling Pathways

“…Osteoporosis has debilitating systemic effects in patients with silicosis, 6 horses with silicate-associated osteoporosis, 7 and rats that have inhaled silica. 8 Our previous study showed that low bone mineral density (BMD) can occur independently of established silicosis–osteoporosis risk factors such as age, nutrition, medical treatment, and immobility.…”

“…1 Apart from silicosis, silica-induced inflammatory activation induces the development of various respiratory and non-respiratory conditions including silicosis, autoimmune disease, sarcoidosis, lung cancer, pulmonary infections, and renal disease. [2][3][4][5] Osteoporosis has debilitating systemic effects in patients with silicosis, 6 horses with silicate-associated osteoporosis, 7 and rats that have inhaled silica. 8 Our previous study showed that low bone mineral density (BMD) can occur independently of established silicosisosteoporosis risk factors such as age, nutrition, medical treatment, and immobility.…”

Multifocal discrete osteolysis in a horse with silicate associated osteoporosis

“…central California coast) (Arens et al 2011), and cases diagnosed in nonendemic sites had previous exposure to cristobalite-rich soils. The osteoporosis comorbidity has been recognised in horses and implicated in rare reports in humans (Arens et al 2011;Yildizgoren et al 2014Yildizgoren et al , 2016. The pathogenesis of the skeletal manifestation remains unknown.…”