Evaluation of Bone Metastases From Renal Cell Carcinoma

Abstract

Twenty-nine cases of bone metastases from renal cell carcinoma were examined. Eight had metastatic bone pain as the initial symptom and were diagnosed that the primary lesion was in a kidney. In eight cases bone metastases appeared after treatment of the primary site. Seven had only bone metastases and another 22 cases had multiple metastases in organs such as the lung and lymph node when the bone metastasis was found. Curable surgical treatment was performed in only 2 cases. The survival curve of these patients were: 1 year; 41 per cent, 2 year; 30 per cent and 3 year; 15 per cent. Bone scan used for detection of bone metastases of carcinoma frequently ends with false positive results. CT scan and angiography are available for differential diagnosis of bone metastasis. We examined 6 cases (9 lesions) of bone metastases from renal cell carcinoma (3 pelvic bones, 2 lumbar bones, 2 femurs and 2 humerus). All lesions were hypervascular by angiography and were easily diagnosed as bone metastases. For early detection of bone metastases from renal cell carcinoma, angiography is useful because hypervascularity and tumor stain are easily detected even in such small lesions as 2 cm. Angiography was also useful for chemoembolization.

Gamma‐knife radiosurgery for brain metastasis of renal cell carcinoma: Results in 42 patients

“…Vascular tumors can be treated by embolization or chemoembolization, with high expectation of response. We observed metastatic renal tumor to the bone could be detected by angiography, because metastatic renal tumors are hypervascular 10 . Bone metastasis from RCC can be treated by intra‐arterial infusion chemotherapy using vinblastine and epirubicine 22 .…”

“…In 4 liver metastasis cases, extirpation was performed in 1 case. Hepatic arterial infusion and embolization 9,10 were performed in 3 cases and PR was obtained in 2 cases. In 11 cases of bone metastasis, 4 cases received irradiation, and 2 cases underwent arterial infusion and embolization.…”

The benefits of surgery in the treatment of pelvic metastases

“…In contrast in 1981 it was 19 months, depending on the primary tumour [11]. The survival time of those with metastases from carcinoma of the lung was reported as 3.6 months, compared with 11.8 months for carcinoma of the kidney, 22.6 months for the breast and 29.3 months for the prostate cancer [8,11,14].…”

Gamma‐knife radiosurgery for brain metastasis of renal cell carcinoma: Results in 42 patients

“…In 4 liver metastasis cases, extirpation was performed in 1 case. Hepatic arterial infusion and embolization 9,10 were performed in 3 cases and PR was obtained in 2 cases. In 11 cases of bone metastasis, 4 cases received Fig.…”

“…We observed metastatic renal tumor to the bone could be detected by angiography, because metastatic renal tumors are hypervascular. 10 Bone metastasis from RCC can be treated by intra-arterial infusion chemotherapy using vinblastine and epirubicine. 22 Some metastatic liver tumors from colorectal and esophageal cancer are successfully treated HAI.…”