Evaluation of bone metabolic markers in breast cancer with bone metastasis

Wada, Noriaki; Fujisaki, Masato; Ishii, Shin; Ikeda, Tadashi; Kitajima, Masaki

doi:10.1007/bf02967492

Cited by 52 publications

(38 citation statements)

References 20 publications

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“…Levels of TRAP activity in the serum in this study were about 1/6 of that in previous studies on healthy adult humans [1,21,24,26], and serum TRAP activity was significantly correlated with the serum hydroxyproline concentration. From these results, TRAP activity is a useful index of bone resorption even though the activities were low.…”

supporting

confidence: 59%

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Serum Activities of Tartrate-Resistant Acid Phosphatase and Bone Specific Alkaline Phosphatase as Indices of Bone Metabolism in the Cow.

Sato

Okada

Fukuda³

et al. 2002

The Journal of Veterinary Medical Science

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ABSTRACT. The correlation between the serum hydroxyproline concentration and serum activity levels of TRAP and BALP was examined in 41 cows. The correlated coefficient (r) was 0.6391 for TRAP and 0.3147 for BALP, respectively. Judging from the significant correlation to the serum hydroxyproline concentration, serum TRAP activity is an index for bone metabolism in cows. Serum TRAP activity was therefore measured in 205 healthy cows (2-9 years old) in order to observe the changes in bone resorption with aging and mil k production. TRAP levels differed slightly between group A (≤4 yrs) and B (5 yrs≤) at the same stage of lactation. The activity levels rose slightly at the height of lactation stage and during the dry stage. KEY WORDS: bone metabolism, cattle, serum TRAP activity.J. Vet. Med. Sci. 64 (7): [653][654][655] 2002 Milk fever (hypocalcemia) occurs due to the acute depletion of blood Ca during the rapid onset of milk production [8]. Goff and Horst reported that milk fever was successfully prevented by stimulating bone resorption through the regulation of dietary minerals [3,5]. Moreover, Yarrington et al. reported that severe milk fever occurred in periparturiental cows administered a bone resorption depressor over long periods [27,28]. The importance of Ca homeostasis in Ca mobilization from the bone to prevent milk fever has been recognized [3-5, 27, 28].Bone metabolic indices in the serum or urine have been utilized for evaluations in humans and animals [1,9,11,17,21,23]. Serum activities of tartrate-resistant acid phosphatase (TRAP) originating from osteoclasts and bone specific alkaline phosphatase (BALP) from osteoblasts have been recognized as general indices for the diagnosis and monitoring the effectiveness of the treatment of metabolic bone disorders in human [1,10,11,21]. In cattle, collagen metabolite (i.e. hydroxyproline) concentrations in serum and urine have been utilized to evaluate bone metabolism [3-5, 15, 16], however measuring collagen metabolites is complicated, time-consuming process [2,23]. In this study, we evaluated TRAP and BALP in serum, both easily measured, as bone metabolic indices in the cow.Blood samples were obtained from 41 healthy Holstein Friesian cows (2-6 years old). The blood was incubated at 37°C for 1 hr and centrifuged to separate the serum. Serum samples were frozen at -20°C until analyzed. Milk samples were obtained from 6 healthy cows, mixed with 1N HCl to lower the pH to 4.6, and centrifuged at 4°C to separate the whey. The TRAP activity in serum was measured by Lau's method [14]. Heparin (23,000 U/l) was added to the reaction mixture and the pH was adjusted to 6.6 with 1N NaOH to measure the TRAP from osteoclasts specifically [18]. BALP activity in the serum and whey was measured by Rosalki's method [22]. The serum hydroxyproline concentration was measured by Dabev and Struck's method [2]. Pearson's correlation coefficients between hydroxyproline concentration and activities of TRAP and BALP were then evaluated. Significance of the correlation coefficients w...

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supporting

confidence: 59%

“…TRAP activity in serum has been utilized as a bone resorption marker for diagnosis and monitoring of the effectiveness of treatment of metabolic bone disorders in humans [1,21,24,26]. Lau et al isolated TRAP from bovine bone matrix, and reported that it resembled human TRAP originating from osteoclasts in biological character [13].…”

mentioning

confidence: 99%

Serum Activities of Tartrate-Resistant Acid Phosphatase and Bone Specific Alkaline Phosphatase as Indices of Bone Metabolism in the Cow.

Sato

Okada

Fukuda³

et al. 2002

The Journal of Veterinary Medical Science

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“…The authors speculated that this elevation may reflect subclinical bone involvement. Wada et al 63 retrospectively analyzed four bone markers (NTX-I, ICTP, total ALP and TRAP5b) in 156 breast cancer patients, 23 with bone-only metastases, 19 with extraosseous-only metastases and 114 without metastases. Those with BM were further divided by the number of bone lesions.…”

Section: Diagnosis Of Bone Metastasesmentioning

confidence: 99%

Bone remodeling markers and bone metastases: From cancer research to clinical implications

Ferreira¹,

Alho²,

Casimiro³

et al. 2015

BoneKEy Reports

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Bone metastasis is a frequent finding in the natural history of several types of cancers. However, its anticipated risk, diagnosis and response to therapy are still challenging to assess in clinical practice. Markers of bone metabolism are biochemical by-products that provide insight into the tumor-bone interaction, with potential to enhance the clinical management of patients with bone metastases. In fact, these markers had a cornerstone role in the development of bone-targeted agents; however, its translation to routine practice is still unclear, as reflected by current international guidelines. In this review, we aimed to capture several of the research and clinical translational challenges regarding the use of bone metabolism markers that we consider relevant for future research in bone metastasis.

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“…Patients with advanced cancer and bone metastases typically have elevated levels of the bone turnover markers (BTM) urinary N-telopeptide (uNTx), an indicator of osteoclast activity, and serum bone-specific alkaline phosphatase (sBSAP), an indicator of osteoblast activity (6,7,(30)(31)(32). Both denosumab and zoledronic acid have been shown to significantly reduce uNTx and sBSAP levels (33,34), and these two BTMs have been investigated as potential prognostic factors for monitoring patients with cancer who are receiving bone antiresorptive agents.…”

Section: Introductionmentioning

confidence: 99%

Changes in Bone Turnover Marker Levels and Clinical Outcomes in Patients with Advanced Cancer and Bone Metastases Treated with Bone Antiresorptive Agents

Lipton

Smith

Fizazi

et al. 2016

Clinical Cancer Research

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Purpose: Bone antiresorptive agents can significantly reduce bone turnover markers (BTM) in patients with advanced cancer. We evaluated association of changes in BTMs with overall survival (OS), disease progression (DP), and disease progression in bone (DPB) in patients with advanced cancer and bone metastases following denosumab or zoledronic acid treatment.Experimental Design: This is an integrated analysis of patient-level data from three identically designed, blinded, phase III trials with patients randomized to subcutaneous denosumab or intravenous zoledronic acid. Levels of the BTMs urinary N-telopeptide (uNTx) and serum bone-specific alkaline phosphatase (sBSAP) measured at study entry and month 3 were analyzed. OS, DP, and DPB were compared in patients with BTMs ! median versus < median based on month 3 assessments.

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Evaluation of bone metabolic markers in breast cancer with bone metastasis

Abstract: We confirmed that ICTP and TRACP might be useful markers for screening and monitoring BM in breast cancer.

Cited by 52 publications

References 20 publications

Serum Activities of Tartrate-Resistant Acid Phosphatase and Bone Specific Alkaline Phosphatase as Indices of Bone Metabolism in the Cow.

Serum Activities of Tartrate-Resistant Acid Phosphatase and Bone Specific Alkaline Phosphatase as Indices of Bone Metabolism in the Cow.

Bone remodeling markers and bone metastases: From cancer research to clinical implications

Changes in Bone Turnover Marker Levels and Clinical Outcomes in Patients with Advanced Cancer and Bone Metastases Treated with Bone Antiresorptive Agents

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