Evaluation of Bone Metabolic Markers as Indicators of Osteopenia in Climacteric Women

Abstract

Lumbar bone mass (LBM) determination by quantitative computerized tomography in pre-, peri- and postmenopausal women was utilized to identify subjects at risk to develop osteoporosis. The results were related to determinations of bone metabolic markers (serum osteocalcin and urinary calcium excretion). Osteocalcin was the only metabolic marker which underwent significative changes. However, we found very poor correlations between LBM and metabolic markers and it is concluded that bone mass determination remains the method of choice to select women for preventive therapy.

Aminoterminal propeptide of type I procollagen (PINP) correlates to bone loss and predicts the efficacy of antiresorptive therapy in pre- and post-menopausal non-metastatic breast cancer patients

“…Several attempts have been made to identify rapid bone losers by measuring biochemical markers of bone turnover. The best correlation between bone markers and bone loss rate, so far, has been British Journal of Cancer (1998) Riis, 1991Riis, , 1993Uebelhart et al, 1991;Pansini et al, 1992;Seibel et al, 1993 Melkko et al, 1996). Our study implies that the measurement of the PINP level change is an effective method to determine the rate of bone loss.…”

“…A decrease in bone turnover markers has also been documented during calcitonin and bisphosphonate treatment in post-menopausal osteoporosis (Garnero et al, 1994b;Gertz et al, 1994;Nielsen et al, 1994;Lyritis et al, 1995;Pedrazzoni et al, 1995). The best correlation between bone markers and bone loss rate, so far, has been demonstrated by combining measurements of several resorption and formation markers Riis, 1991Riis, , 1993Uebelhart et al, 1991;Pansini et al, 1992;Seibel et al, 1993).…”