Evaluation of bone formation after sagittal split ramus osteotomy using different fixation materials

Efficacy and morbidity of biodegradable versus titanium osteosyntheses in orthognathic surgery: A systematic review with meta‐analysis and trial sequential analysis

“…No study included only paediatric patients. Sixteen studies included patients with class III, [ 14 , 18 , 19 , 20 , 37 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ] six studies with class II, [ 15 , 16 , 50 , 51 , 52 , 53 ] and 10 studies with both class II and class III malocclusion patients [ 2 , 13 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. One study did not specify the malocclusion of the included patients [ 17 ].…”

“…Of all included articles, 14 were publications of RCTs, [ 2 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 50 , 54 , 55 , 56 , 57 ] and 4 of these publications were from the same RCT with different follow‐up times [ 2 , 55 , 56 , 57 ]; three were prospective cohort studies [ 45 , 51 , 52 ]; and 16 were retrospective cohort studies [ 37 , 39 , 40 , 41 , 42 , 43 , 44 , 46 , 47 , 48 , 49 , 53 , 58 , 59 , 60 , 61 ]. Seven publications of RCTs were assessed having ‘some concerns’ regarding risk of bias (Table 2 ).…”

“…Two studies reported funding from research programmes [ 15 , 42 ] and one from the manufacturer of biodegradable osteosyntheses [ 13 ]. Funding or conflict of interest was not reported in 20 studies [ 14 , 16 , 17 , 18 , 19 , 20 , 37 , 39 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 53 , 59 , 60 ]. The other studies declared no funding or conflict of interest [ 2 , 40 , 41 , 52 , 54 , 55 , 56 , 57 , 58 , 61 ].…”

“…All effect estimates of pooled endpoints are presented as RR or SMD (95% CI) including the quality of evidence. Five studies reported on malunion (Table S5 ) [ 19 , 44 , 47 , 49 , 55 ]. In one RCT malunion was found present at 8 weeks of follow‐up in 3% of biodegradable osteosyntheses and 0% of titanium osteosyntheses [ 55 ].…”

“…Mobility of bone segments at 6–12 weeks follow‐up was evaluated in 10 studies (Table S5 ) [ 14 , 17 , 19 , 41 , 44 , 47 , 49 , 54 , 58 , 59 ]. Mobility of bone segments was assessed as not present in seven studies [ 19 , 41 , 44 , 47 , 49 , 58 , 59 ].…”