Evaluation of blood circulation of polysaccharide surface-decorated PLA nanoparticles

Ma, Wei; Yuan, Xubo; Kang, Chunsheng; Su, Teng; Yuan, Xiaoyan; Pu, Peiyu; Sheng, Jing

doi:10.1016/j.carbpol.2007.07.033

Cited by 39 publications

(25 citation statements)

References 18 publications

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“…[13][14][15][16] Even if some of these NPs showed stealth properties, their brain concentration was found close to zero. 14 Very few studies have appeared on the derivatization of polyester NPs (PLGA or PLA) with peptides so as to improve their targeting properties.…”

mentioning

confidence: 92%

Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution

Vergoni

Tosi

Tacchi

et al. 2009

Nanomedicine: Nanotechnology, Biology and Medicine

126

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mentioning

confidence: 92%

Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution

Vergoni

Tosi

Tacchi

et al. 2009

Nanomedicine: Nanotechnology, Biology and Medicine

126

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“…[5] Among the polymers, PLGA is the most used for this purpose because of its well known safety use in humans. [6] PLGA is a nontoxic and biocompatible polyester, approved by the FDA. [7] However its properties can be improved by combination with other polymers, such as PEG.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Drug Delivery Profile of Magnetic PLGA‐PEG‐PLGA/Maghemite Nanocomposite

Pereira

Souza

Pinto

et al. 2014

Macromolecular Symposia

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Summary: The antibiotic cotrimoxazole was associated to the multi-block copolymer containing poly(D,L-lactic-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) segments, PLGA-PEG-PLGA, aiming to reach a controlled drug release system. Block copolymer was synthesized via polycondensation of lactic acid and glycolic acid with PEG in situ. In turn, maghemite was synthesized through the co-precipitation method. The drug cotrimoxazole was inserted in the composite through melting mixing method. Several techniques were used to characterize the materials. The materials were characterized by Nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and magnetic force, this last according to the methodology developed by our group. In addition, dissolution profile was studied. These dissolution tests were performed with and without magnetic field, aiming to study the influence of the magnetic field on the dissolution profile. The dissolution was monitored and quantified using the ultraviolet-visible spectrophotometry (UV-Vis), following the USP method for cotrimoxazole tablets. Results demonstrated that nanocomposites presented a good magnetic force, able to keep the magnetic composite trapped in a specific place or tissue. Furthermore, in the presence of a magnetic field, the magnetic nanoparticles were able to perform a magnetic constriction of the material, making the drug release faster than in the absence of the magnetic field. This phenomenon may be useful to perform a fine tuning of the system, allowing the easier adjust of the speed and amount of released drug, useful to improve medical treatments and even the welfare of the patients.

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“…The effect of dextran conformation on self-assembly behavior of micelles should be conducted in more detail. Coating of poly(lactic acid) nanoparticles with dextran induced a diminished protein adsorption [115]. Again, conformation of dextran played an important role because blood circulation time was not increased and the authors attributed this to the loop conformation of the polysaccharide chains.…”

Section: Biomimetic Approaches Used For Drug Carriersmentioning

confidence: 99%

Engineering Antiphagocytic Biomimetic Drug Carriers

Sawdon

Peng

2013

Ther. Deliv.

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Drug-delivery carriers have the potential to not only treat but also diagnose many diseases; however, they still lack the complexity of natural-particulate systems. Cell-based therapies using tumor-targeting T cells and tumor-homing mesenchymal stem cells have given researchers a means to exploit the characteristics exhibited by innate-biological entities. Similarly, immune evasion by pathogens has inspired the development of natural polymers to cloak drug carriers. The ‘marker-of-self’ CD47 protein, which is found ubiquitously on mammalian cell surfaces, has been used for evading phagocyte clearance of drug carriers. This review will focus on the recent progress of drug carriers co-opting the tricks that cells in nature use to hide safely under the radar of the body’s innate immune system.

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Evaluation of blood circulation of polysaccharide surface-decorated PLA nanoparticles

Cited by 39 publications

References 18 publications

Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution

Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution

Synthesis, Characterization and Drug Delivery Profile of Magnetic PLGA‐PEG‐PLGA/Maghemite Nanocomposite

Engineering Antiphagocytic Biomimetic Drug Carriers

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