Evaluation of biventricular function in patients with COVID-19 using speckle tracking echocardiography

Baycan, Ömer Faruk; Barman, Hasan Ali; Atıcı, Adem; Tatlısu, Adem; Bölen, Furkan; Ergen, Pınar; İçten, Sacit; Güngör, Barış; Çalışkan, Mustafa

doi:10.1007/s10554-020-01968-5

Cited by 95 publications

(144 citation statements)

References 44 publications

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“…Few studies have reported LV-GLS in the context of COVID-19 infection. In a study of 100 patients hospitalized with COVID-19, Baycan et al found that patients with acute COVID-19 infection had lower LV-GLS values, which was an independent predictor of in-hospital mortality [35] . However, the frequency of abnormal LV-GLS was not reported.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular global longitudinal strain in identifying subclinical myocardial dysfunction among patients hospitalized with COVID-19

Shmueli¹,

Shah²,

Ebinger³

et al. 2021

IJC Heart & Vasculature

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Section: Discussionmentioning

confidence: 99%

Left ventricular global longitudinal strain in identifying subclinical myocardial dysfunction among patients hospitalized with COVID-19

Shmueli¹,

Shah²,

Ebinger³

et al. 2021

IJC Heart & Vasculature

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“…Inflammation is thought to cause RV overload and damage that resulted in RV failure, which can be assessed by RV-LS [17]. Free wall has a more excellent prognostic value than total RV strain in patients with COVID-19 [16]. One of RV-LS's advantage is that the performance of RV-LS as a prognostication tool is independent of LV systolic functional index [8].…”

Section: Discussionmentioning

confidence: 99%

“…Baycan et al reported that LV-GLS > − 15.2% has an OR of 8.34, area under a curve (AUC) 0.83, sensitivity of 77%, and specificity of 75%, while RV-LS > − 18.45% has an OR of 6.23, AUC 0.77, sensitivity of 72%, and specificity of 66% [16]. Li et al found that RV-LS at − 23% cutoff was associated with AUC 0.87, sensitivity of 94.4%, and specificity of 64.7% [8].…”

Section: Discussionmentioning

confidence: 99%

“…Three full-text articles were excluded because (1) comparison was between cardiac vs non-cardiac injury (n = 1); (2) comparison was between COVID-19 (+) vs COVID-19 (-) (n = 1); and (3) case series with inadequate comparison (n = 1). There were seven studies comprising of 612 patients in the qualitative and quantitative synthesis [4,[6][7][8][15][16][17]. The baseline characteristics of the included studies are displayed in Table 1.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

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Left and right ventricular longitudinal strains are associated with poor outcome in COVID-19: a systematic review and meta-analysis

et al. 2021

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Background This systematic review and meta-analysis aimed to assess whether ventricular longitudinal strain can be used as a prognostication tool in patients with coronavirus disease 2019 (COVID-19). Methods Systematic literature searches of PubMed, Embase, and EuropePMC databases were performed on 16 November 2020. Left ventricular global longitudinal strain (LV-GLS) refers to LV contraction measurement using the speckle tracking-based method refers to the mean of strain values of the RV free wall (three segments) measured using echocardiography. The main outcome was poor outcome, defined as a composite of mortality and severe COVID-19. Results Seven studies comprising of 612 patients were included in meta-analysis. Six studies have mortality as their outcome, and 1 study has severity as their outcome. Patients with poor outcome have lower LV-GLS (SMD 1.15 (0.57, 1.72), p < 0.001; I2 70.4%). Each 1% decrease in LV-GLS was associated with 1.4x increased risk of poor outcome (OR 1.37 (1.12, 1.67), p = 0.002; I2 48.8%). Patients with poor outcome have lower RV-LS (SMD 1.18 (0.91, 1.45), p < 0.001; I2 0%). Each 1% decrease in RV-LS was associated with 1.3x increased risk of poor outcome (OR 1.25 (1.15, 1.35), p < 0.001; I2 11.8%). Subgroup analysis showed that for every 1% decrease in LV-GLS and RV-LS is increased mortality with OR of 1.30 (1.12, 1.50) and OR of 1.24 (1.14, 1.35), respectively. Conclusion This study shows that lower LV-GLS and RV-LS measurements were associated with poor outcome in patients with COVID-19. Trial registration PROSPERO CRD42020221144

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“…undergoing echocardiography exist and are limited in scope[13,17,18]. Thus, the clinical importance of cardiac dysfunction in critical illness caused by COVID-19 is not yet established.…”

mentioning

confidence: 99%

Cardiac Dysfunction in Critically Ill patients with COVID-19 – A Multicentre Observational Study

Holmqvist

Beck-Friis

Jensen

et al. 2021

Preprint

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Introduction: The importance of cardiac dysfunction in critically ill patients with COVID-19 is not well studied. The aim of the study was to assess the incidence, clinical risk factors, and prognosis of cardiac dysfunction in critical illness caused by COVID-19, and to evaluate if cardiac biomarkers can detect this condition.Methods: This was a multicentre observational study performed in five intensive care units (ICUs) in Sweden. Patients admitted to participating ICU with COVID-19 were examined with echocardiography within 72 hours from admission to the ICU and again after four to seven days. Cardiac biomarkers and clinical data were collected at the time of echocardiography. Cardiac dysfunction was defined as either left ventricular (LV) dysfunction (having an ejection fraction < 50% and/or regional hypokinesia) or right ventricular (RV) dysfunction (having a tricuspid annular plane systolic excursion (TAPSE) < 17mm or a moderate/severe RV dysfunction assessed visually).Results: We included 132 patients of whom 94 (71%) were included prospectively. The vast majority were intubated (n=127). At the time of admission to ICU, 35 (27%) patients had cardiac dysfunction and 7 patients (5%) had cardiac dysfunction detected later in the ICU-period. LV dysfunction was found in 18 patients and RV dysfunction in 17 patients, 7 patients had both RV and LV dysfunction. Noradrenaline > 0.20µg/kg/min was the only clinical variable associated with a higher risk of cardiac dysfunction. RV dysfunction was associated with an increased risk of death in a risk-adjusted model (OR 3.98, p = 0.013). Troponin and N-terminal pro b-type natriuretic peptide (NTproBNP) had moderate values in detecting cardiac dysfunction (AUC 0.729 and AUC 0.744, respectively). A combination of troponin < 1.44 times the upper reference limit and NTproBNP < 857ng/L had 85% probability of excluding cardiac dysfunction.Conclusions: Cardiac dysfunction is common in critically ill patients with COVID-19. Although not easily detected with clinical variables, cardiac biomarkers might be helpful. RV dysfunction is associated with an increased risk of death, these patients might benefit from further investigation or treatments. Trial registration: Registered on 24 Aug 2020 at Clinicaltrials.gov; registration number NCT04524234.

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Evaluation of biventricular function in patients with COVID-19 using speckle tracking echocardiography

Cited by 95 publications

References 44 publications

Left ventricular global longitudinal strain in identifying subclinical myocardial dysfunction among patients hospitalized with COVID-19

Left ventricular global longitudinal strain in identifying subclinical myocardial dysfunction among patients hospitalized with COVID-19

Left and right ventricular longitudinal strains are associated with poor outcome in COVID-19: a systematic review and meta-analysis

Cardiac Dysfunction in Critically Ill patients with COVID-19 – A Multicentre Observational Study

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