Evaluation of bismuth subgallate and adrenaline paste as haemostat in tonsillectomy bleeding

Sharma, Karan; Kumar, Devinder; Sheemar, S.

doi:10.1007/s12070-007-0088-0

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…In accordance with other studies, we observed an improvement in the time required for the achievement of hemostasis with the use of adrenaline (Rasgon et al, 1991;Sharma et al, 2007).…”

Section: Discussionsupporting

confidence: 92%

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Hemostasis during cold dissection tonsillectomy: Comparing the use of adrenaline and normal saline

Adoga¹,

Okeke²

2011

J. Clin. Med. Res.

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Various hemostatic agents and techniques have been used to reduce intraoperative and postoperative hemorrhage in tonsillectomy. This study aims to compare the effect of using adrenaline and normal saline in maintaining hemostasis during cold dissection tonsillectomy. This is a prospective randomized single-blind study spanning fifty seven months in a private hospital setting in Jos, Plateau State, Nigeria. Thirty seven patients aged between 2 and 31 years had tonsillectomy consisting of 22 (59.5%) males and 15 (40.5%) females. The mean age of patients was 15.6 years (SD= ± 8.97). Recurrent tonsillitis (45.9%) was the commonest indication for surgery and obstructive sleep apnea was the commonest associated indication in 12 (32.4%) patients. In 12 (32.4%) patients, there was no associated indication for surgery. The mean time required to achieve hemostasis with the use of adrenaline soaked gauze compress was 3.84 min. (SD= ± 0.92) and with the normal saline soaked gauze compress was 4.15 min. (SD=± 0.81) with a difference of 0.31 min. There was no incidence of primary, reactionary or secondary hemorrhage. The local application of adrenaline as a topical hemostatic agent during tonsillectomies is effective in reducing intraoperative and postoperative hemorrhage and invariably reducing operative time with no significant side effects or complications.

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“…In accordance with other studies, we observed an improvement in the time required for the achievement of hemostasis with the use of adrenaline (Rasgon et al, 1991;Sharma et al, 2007).…”

Section: Discussionsupporting

confidence: 92%

“…This has prompted the use of a variety of topical haemostatic agents such as bismuth subgallate and adrenaline to achieve hemostasis and reduce the risk of intra and postoperative hemorrhage (Rasgon et al, 1991;Agrawal et al, 2005;Sharma et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Hemostasis during cold dissection tonsillectomy: Comparing the use of adrenaline and normal saline

Adoga¹,

Okeke²

2011

J. Clin. Med. Res.

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“…Hatton et al reported that topical adrenaline is an effective hemostatic agent in tonsillectomy 11 . The application of bismuth subgallate and adrenaline paste to the tonsillar fossae reduced the operating time by 23% and blood loss by 21% 27 . Epinephrine, a platelet-stimulating agent, can cause aggregation of human platelets through alpha-adrenergic mechanisms 28 .…”

Section: Discussionmentioning

confidence: 99%

Comparison Benefit between Hydrogen Peroxide and Adrenaline in Tonsillectomy: A Randomized Controlled Study

Hsieh

Hsu

et al. 2021

Preprint

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This study aimed to further evaluate the benefit of topical hemostasis agents in tonsillectomy. Towards this goal, we compared the clinical effects of topical application between hydrogen peroxide and adrenaline in tonsillectomy. Overall, 60 patients (120 tonsils) were prospectively enrolled for tonsillectomy between February 2018 and December 2020. The patients were randomly assigned to either the hydrogen peroxide or adrenaline group. Then, tonsillectomy was performed using hydrogen peroxide as a hemostatic agent on the assigned side, while adrenaline was applied to the other side. All procedures were performed by a surgeon blinded to the randomization. Outcome measurements of operation time, intraoperative blood loss, postoperative pain, and hemorrhage events were analyzed.The intraoperative blood loss was significantly lower in the hydrogen peroxide group than in the adrenaline group (9.99 ± 4.51 ml vs 13.87 ± 6.32 ml, p = 0.0). The median operation time was also significantly lower in the hydrogen peroxide group (8.02 ± 3.59 min vs 9.22 ± 3.88 min, p = 0.019). Meanwhile, the visual analogue scale (VAS) scores were significantly higher in the hydrogen peroxide group (4.98 ± 1.94 vs 4.27 ± 1.97, p = 0.001). The topical application of hydrogen peroxide as a hemostatic agent effectively decreases the operation time and intraoperative blood loss. Thus, hydrogen peroxide can be used as a routine hemostatic agent for bleeding control in tonsillectomy.

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“…Hatton et al reported that topical adrenaline is an effective hemostatic agent in tonsillectomy [ 11 ]. The application of bismuth subgallate and adrenaline paste to the tonsillar fossae reduced the operating time by 23% and blood loss by 21% [ 28 ]. Epinephrine, a platelet-stimulating agent, can cause aggregation of human platelets through alpha-adrenergic mechanisms [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison Benefit between Hydrogen Peroxide and Adrenaline in Tonsillectomy: A Randomized Controlled Study

Hsieh¹,

Hsu

et al. 2022

JCM

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This study aimed to further evaluate the benefit of topical hemostasis agents in tonsillectomy. We compared the clinical effects of topical application between hydrogen peroxide and adrenaline in tonsillectomy. Overall, 60 patients (120 tonsils) were prospectively enrolled for tonsillectomy between February 2018 and December 2020. The patients were randomly assigned to either the hydrogen peroxide or adrenaline group. Then, tonsillectomy was performed using hydrogen peroxide as a hemostatic agent on the assigned side, while adrenaline was applied to the other side. All procedures were performed by a surgeon who was blinded to the randomization. The outcome measurements of operation time, intraoperative blood loss, postoperative pain, and hemorrhage events were analyzed. The intraoperative blood loss was significantly lower in the hydrogen peroxide group than in the adrenaline group (9.99 ± 4.51 mL vs. 13.87 ± 6.32 mL; p = 0.0). The median operation time was also significantly lower in the hydrogen peroxide group (8.02 ± 3.59 min vs. 9.22 ± 3.88 min; p = 0.019). Meanwhile, the visual analogue scale (VAS) scores were significantly higher in the hydrogen peroxide group (4.98 ± 1.94 vs. 4.27 ± 1.97; p = 0.001). The topical application of hydrogen peroxide as a hemostatic agent effectively decreases the operation time and intraoperative blood loss. Thus, hydrogen peroxide can be used as a routine hemostatic agent for bleeding control in tonsillectomy.

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Evaluation of bismuth subgallate and adrenaline paste as haemostat in tonsillectomy bleeding

Cited by 3 publications

References 9 publications

Hemostasis during cold dissection tonsillectomy: Comparing the use of adrenaline and normal saline

Hemostasis during cold dissection tonsillectomy: Comparing the use of adrenaline and normal saline

Comparison Benefit between Hydrogen Peroxide and Adrenaline in Tonsillectomy: A Randomized Controlled Study

Comparison Benefit between Hydrogen Peroxide and Adrenaline in Tonsillectomy: A Randomized Controlled Study

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