Evaluation of biomolecular interactions and cytotoxic activity of organometallic binuclear Ru(II) complexes of ferrocenyl thiosemicarbazones

Synthesis, characterization, interactions with the DNA duplex dodecamer d(5′-CGCGAATTCGCG-3′)2and cytotoxicity of binuclear η6-arene-Ru(ii) complexes

“…† The values of binding constants were in the range of 10 3 -10 4 M −1 , suggesting moderate binding affinity of the complexes, with the number of binding sites practically being one. 55 All the above results suggest that the complexes ( 4) and (1) were the most effective in competing the EtBr, with the tendency for all complexes to be: (4) > (1) > ( 3) > ( 2) > ( 5) > (6). Also, the binding constants of ( 4) and (1) were one order of magnitude greater than the other studied complexes.…”

“…The values of binding constants were in the range of 10 3 –10 4 M −1 , suggesting moderate binding affinity of the complexes, with the number of binding sites practically being one. 55…”

Synthesis and Characterization of Ruthenium-Paraphenylene-Cyclopentadienyl Full-Sandwich Complexes: Cytotoxic Activity against A549 Lung Cancer Cell Line and DNA Binding Properties

“…The binding constants (K b ) and the number of binding sites (n) were estimated using fluorescence titration data and calculated through the double logarithmic plot log [F 0 - F/F] versus log[Q] ( Figure S7 ). The values of the binding constant were in the order of magnitude of 10 3 M −1 , indicating moderate binding of the complexes with the number of binding sites practically being one [ 39 ]. The results are summarized in Table 2 .…”