Evaluation of biological potential and physico-chemical properties of Acridocarpus orientalis (Malpighiaceae)

Differential Cytotoxic Potential of Acridocarpus orientalis Leaf and Stem Extracts with the Ability to Induce Multiple Cell Death Pathways

“…The biologically active components of medicinal plants normally include flavonoids, phenolics, and polyphenols with promising anticancer activities [53,54]. We have previously shown that A. orientalis extracts/fractions contain substantial amounts of flavonoids and phenolic compounds with effective antioxidant, lipid peroxidation, and cytotoxic activities against colorectal and liver cancer cells, such as HT29, HCT116, and HepG2 [22]. A subset of these fractions was also shown to contain inhibitory potential against two enzymes important for sugar metabolism and survival of bacteria in the host; α-glucosidase and urease enzymes, respectively [22].…”

“…We have previously shown that A. orientalis extracts/fractions contain substantial amounts of flavonoids and phenolic compounds with effective antioxidant, lipid peroxidation, and cytotoxic activities against colorectal and liver cancer cells, such as HT29, HCT116, and HepG2 [22]. A subset of these fractions was also shown to contain inhibitory potential against two enzymes important for sugar metabolism and survival of bacteria in the host; α-glucosidase and urease enzymes, respectively [22]. Furthermore, we have reported isolation of two different flavonoids with anti-proliferation activity against the same colorectal and liver cancer cells [20].…”

“…The air-dried whole plant material (8.2 kg) of A. orientalis was collected from different places of Al-Hamra , in Ad-Dakhiliyah region of the Oman (2012) and identified by a plant taxonomist at the Department of Biological Sciences and Chemistry, University of Nizwa, Nizwa, Oman [22].…”

“…The extraction and fractionation of the leaf and stem parts of the plant has been described before [22]. Briefly, the powdered plant material of leaves (AO (L), 3.3 kg) and stem (AO (S), 4.1 kg) was initially soaked in methanol with vigorous shaking.…”

“…Despite a wealth of information regarding the phytochemical composition of this plant, not much is known about its anticancer potential. Thus, we carried out a systematic analysis of the anticancer potential of leaves and stems of A. orientalis by testing sequential organic fractions of their methanolic extracts that had earlier shown to have some cytotoxic potential [22]. After confirming their anti-proliferation potential in various human breast and cervical cancer cell lines, the mechanism of action of their fractions was explored by characterizing their ability to induce apoptosis, an important cell death pathway activated by anticancer agents [23,24].…”