Evaluation of Bioglass/dextran composite as a bone graft substitute

Chan, Carolyn S. K.; Thompson, Ian D.; Robinson, Paul D.; Wilson, June; Hench, Larry L.

doi:10.1054/ijom.2001.0143

Cited by 66 publications

(58 citation statements)

References 9 publications

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“…This avoids second donor-site morbidity, reduces the surgical time, length of the hospital stay, chances of graft rejection, and wound infection as well as cut down on the cost factor for the patient. [14][15][16][17][18][19][20] In the present study, we did not encounter any complication except for pain for duration of 2 weeks in 3 patients and parasthesia for 3 months in 6 cases, which was partly attributed to the use of Carnoy's solution. The pain was successfully managed by routine analgesic therapy (500 mg Paracetamol three times a day for three day).…”

Section: Resultssupporting

confidence: 46%

“…[11][12][13][14][15] Spontaneous bone regeneration of large defects is an unexpected phenomenon, but in the presence of intact periosteum as a source of osteogenic tissue, mandibular stabilization, and young age of the patients, spontaneous bone regeneration of mandibular defects can occur. [16][17][18] The spontaneous bone regeneration in our case studies had a cyst size ranging from 3 to 10 cm, mean size being 4.8 cm. All were treated by enucleation and left for spontaneous bone healing.…”

Section: Resultsmentioning

confidence: 72%

See 1 more Smart Citation

Evaluation of Spontaneous Bone Regeneration after Enucleation of Large Cysts of the Jaws using Radiographic Computed Software

Wagdargi

Kumar

Arunkumar

et al. 2016

The Journal of Contemporary Dental Practice

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Introduction: Spontaneous regeneration of bone is commonly seen in the small surgical defects caused by enucleation of cysts. However, in case of large surgical defects caused by the enucleation, spontaneous regeneration of bone is a rare phenomenon and it depends on factors, such as age of the patient, intact periosteum, and proper stabilization. Materials and methods:The study included 16 patients, who reported to the department of oral and maxillofacial surgery with the complaint of pain and swelling in the jaws diagnosed as cyst. The sample included equal numbers of male and female subjects aged between 15 and 40 years. Panoramic radiographs were taken pre-and postoperatively on day 2 of the enucleation.The dimensions of the cyst were evaluated on the radiograph according to the proforma. Subsequent radiographs were taken at regular intervals of 1.5, 3, and 6 months using standard parameters and were analyzed using MCID™ analysis software of imaging research. Results:Mean reduction was seen in up to 39 and 60% in the cystic cavity size and increase in the mean density up to 59 and 90.2% at 3 and 6 months intervals respectively. Conclusion:Spontaneous bone regeneration was seen even after primary closure of the large cystic defect without the need for placement of foreign substances or grafts and it also eliminated the complications resulting from placement of foreign substance. Further studies are required in a larger sample with

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Section: Resultssupporting

confidence: 46%

Section: Resultsmentioning

confidence: 72%

Evaluation of Spontaneous Bone Regeneration after Enucleation of Large Cysts of the Jaws using Radiographic Computed Software

Wagdargi

Kumar

Arunkumar

et al. 2016

The Journal of Contemporary Dental Practice

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“…4 Settable, weight-bearing bone grafts ideally exhibit both initial bone-like mechanical properties and also remodel with minimal resorption gaps such that the strength of the graft exceeds that of host bone during all stages of healing. Injectable bone void fillers (BVFs) include nonsetting allograft 5 and nonallogenic pastes, 6 which are typically delivered using viscous carriers (e.g., sodium hyaluronate, 7 glycerol, 8 or dextran 9 ) resulting in weak mechanical properties. Resorbable CPCs, [10][11][12][13] such as beta-tricalcium phosphate (b-TCP, slowly resorbed by osteoclasts) or calcium sulfate (CSH) and brushite (undergo dissolution), have also been used to enhance bone healing.…”

Section: Introductionmentioning

confidence: 99%

Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

Dumas

Prieto

Zienkiewicz

et al. 2014

Tissue Engineering Part A

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There is a compelling clinical need for bone grafts with initial bone-like mechanical properties that actively remodel for repair of weight-bearing bone defects, such as fractures of the tibial plateau and vertebrae. However, there is a paucity of studies investigating remodeling of weight-bearing bone grafts in preclinical models, and consequently there is limited understanding of the mechanisms by which these grafts remodel in vivo. In this study, we investigated the effects of the rates of new bone formation, matrix resorption, and polymer degradation on healing of settable weight-bearing polyurethane/allograft composites in a rabbit femoral condyle defect model. The grafts induced progressive healing in vivo, as evidenced by an increase in new bone formation, as well as a decrease in residual allograft and polymer from 6 to 12 weeks. However, the mismatch between the rates of autocatalytic polymer degradation and zero-order (independent of time) new bone formation resulted in incomplete healing in the interior of the composite. Augmentation of the grafts with recombinant human bone morphogenetic protein-2 not only increased the rate of new bone formation, but also altered the degradation mechanism of the polymer to approximate a zero-order process. The consequent matching of the rates of new bone formation and polymer degradation resulted in more extensive healing at later time points in all regions of the graft. These observations underscore the importance of balancing the rates of new bone formation and degradation to promote healing of settable weight-bearing bone grafts that maintain bone-like strength, while actively remodeling.

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“…These were followed by more than a dozen other commercial CPC formulations (Table 2). Recently, efforts towards composites of hydrogels and bone substitutes (Chan et al, 2002;Chazono et al, 2004;Dupraz et al, 1998;Grimandi et al, 1998;Ito, 1991;Maruyama et al, 1995;Momota et al, 2002;Pompili et al, 1998) have been intensified and several products have been launched (Table 3). These efforts are expressed by a rapid increase of the number of publications.…”

Section: Introductionmentioning

confidence: 99%

Design of ceramic-based cements and putties for bone graft substitution

Bohner¹

2010

eCM

272

249

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In the last 15 years, a large number of commercial ceramicbased cements and putties have been introduced as bone graft substitutes. As a result, large efforts have been made to improve our understanding of the specific properties of these materials, such as injectability, cohesion, setting time (for cements), and in vivo properties. The aim of this manuscript is to summarize our present knowledge in the field. Instead of just looking at scientific aspects, industrial needs are also considered, including mixing and delivery, sterilization, and shelf-life.

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Evaluation of Bioglass/dextran composite as a bone graft substitute

Cited by 66 publications

References 9 publications

Evaluation of Spontaneous Bone Regeneration after Enucleation of Large Cysts of the Jaws using Radiographic Computed Software

Evaluation of Spontaneous Bone Regeneration after Enucleation of Large Cysts of the Jaws using Radiographic Computed Software

Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

Design of ceramic-based cements and putties for bone graft substitution

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