Evaluation of biogenically synthesized MgO NPs anticancer activity against breast cancer cells

Rashid Khan, Mohammad; Omar Alafaleq, Nouf; Kumar Ramu, Arun; Alhosaini, Khaled; Shahnawaz Khan, Mohd; Zughaibi, Torki A.; Tabrez, Shams

doi:10.1016/j.sjbs.2023.103874

Saudi Journal of Biological Sciences

2024

DOI: 10.1016/j.sjbs.2023.103874

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Evaluation of biogenically synthesized MgO NPs anticancer activity against breast cancer cells

Mohammad Rashid Khan,

Nouf Omar Alafaleq,

Arun Kumar Ramu

et al.

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2024

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Cited by 3 publications

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Anticancer potential of Cu4O3 NPs against human ovarian teratocarcinoma: an in-vitro validation

Jabir,

Mahboob,

Suhail

et al. 2023

Chem. Pap.

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Anticancer potential of Cu4O3 NPs against human ovarian teratocarcinoma: an in-vitro validation

Jabir,

Mahboob,

Suhail

et al. 2023

Chem. Pap.

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Olive leaf extract green-formulated manganese nanoparticles: Characterization and antioxidant, cytotoxicity and anti-breast carcinoma properties

Feng,

2024

Inorganic Chemistry Communications

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Glyoxalase System in Breast and Ovarian Cancers: Role of MEK/ERK/SMAD1 Pathway

Alhujaily

2024

Biomolecules

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The glyoxalase system, comprising GLO1 and GLO2 enzymes, is integral in detoxifying methylglyoxal (MGO) generated during glycolysis, with dysregulation implicated in various cancer types. The MEK/ERK/SMAD1 signaling pathway, crucial in cellular processes, influences tumorigenesis, metastasis, and angiogenesis. Altered GLO1 expression in cancer showcases its complex role in cellular adaptation and cancer aggressiveness. GLO2 exhibits context-dependent functions, contributing to both proapoptotic and antiapoptotic effects in different cancer scenarios. Research highlights the interconnected nature of these systems, particularly in ovarian cancer and breast cancer. The glyoxalase system’s involvement in drug resistance and its impact on the MEK/ERK/SMAD1 signaling cascade underscore their clinical significance. Furthermore, this review delves into the urgent need for effective biomarkers, exemplified in ovarian cancer, where the RAGE-ligand pathway emerges as a potential diagnostic tool. While therapeutic strategies targeting these pathways hold promise, this review emphasizes the challenges posed by context-dependent effects and intricate crosstalk within the cellular milieu. Insights into the molecular intricacies of these pathways offer a foundation for developing innovative therapeutic approaches, providing hope for enhanced cancer diagnostics and tailored treatment strategies.

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Evaluation of biogenically synthesized MgO NPs anticancer activity against breast cancer cells

Cited by 3 publications

References 54 publications

Anticancer potential of Cu4O3 NPs against human ovarian teratocarcinoma: an in-vitro validation

Anticancer potential of Cu4O3 NPs against human ovarian teratocarcinoma: an in-vitro validation

Olive leaf extract green-formulated manganese nanoparticles: Characterization and antioxidant, cytotoxicity and anti-breast carcinoma properties

Glyoxalase System in Breast and Ovarian Cancers: Role of MEK/ERK/SMAD1 Pathway

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