Evaluation of Biodegradable Stent Graft Coatings in Pig and Rabbit Models

Taavitsainen, Jouni; Tarvainen, Santeri; Kuivanen, Antti; Mangiardi, Eric K; Guelcher, Manfred; Martin, John F.; Mathur, Anthony; Hytönen, Jarkko; Ylä‐Herttuala, Seppo

doi:10.1159/000505454

Cited by 3 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Taavitsainen et al [ 12 ] published a rabbit aorta perforation model. In regard to this paper, it must, however, be mentioned that the authors punctured the aorta by means of a 2-mm biopsy punch after revealing the aorta through a midline abdominal incision.…”

Section: Discussionmentioning

confidence: 99%

A preclinical animal model for evaluating the sealing capacity of covered stent grafts in acute vessel perforation

et al. 2020

View full text Add to dashboard Cite

Background Percutaneous coronary intervention is among the most common therapeutic interventions in cardiology. This procedure may, however, be associated with a rare, though life-threatening complication: acute coronary perforation (CP). CP is primarily treated using covered stents, which are made of bare metal stents with a polytetrafluoroethylene (PTFE) or polyurethane coating. These stents’ major limitations include higher rates of thrombus formation and restenosis. Hence, there is a still unmet need for new stents regarding their design and composition. Or, to test new covered stent designs, the rabbit iliac artery has become the best-established animal model. This study sought to present a preclinical animal approach designed to test covered stents that are utilized following vessel perforation. Methods The animal experiments were performed using New Zealand white rabbits, each weighting 3.5–4.5 kg. The animal models described herein relied on the three most common clinical causes for CP, such as guidewire-induced, balloon catheter bursting, and device oversizing. Moreover, the sealing capacity of covered stent grafts was assessed for each of these models by means of angiography. Results We herein report a rabbit iliac artery perforation model using three different types of vessel perforation that closely mimic the clinical setting, such as guidewire-induced, balloon catheter rupture, and device oversizing. Using the same rabbit iliac perforation model, we additionally assessed the sealing capacity of a covered stent graft for each model. Conclusions The novel rabbit iliac artery perforation models, as described in this report, represent promising animal testing approaches. While their setting is very similar to the real-life context encountered in humans, all three models are based on an animal model that is ideally suited for evaluating the sealing capacity and performance of new medical devices for humans.

show abstract

Section: Discussionmentioning

confidence: 99%

A preclinical animal model for evaluating the sealing capacity of covered stent grafts in acute vessel perforation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…They reported encouraging in vivo results with a fully biodegradable system (Electrospun graft and magnesium stent) with a favorable rate of restenosis and patency. [ 109 ]…”

Section: Current State‐of‐the‐artmentioning

confidence: 99%

The Technological Advancement to Engineer Next‐Generation Stent‐Grafts: Design, Material, and Fabrication Techniques

Vahabli

Mann

Heidari

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Endovascular treatment of aortic disorders has gained wide acceptance due to reduced physiological burden to the patient compared to open surgery, and ongoing stent-graft evolution has made aortic repair an option for patients with more complex anatomies. To date, commercial stent-grafts are typically developed from established production techniques with simple design structures and limited material ranges. Despite the numerous updated versions of stent-grafts by manufacturers, the reoccurrence of device-related complications raises questions about whether the current manfacturing methods are technically able to eliminate these problems. The technology trend to produce efficient medical devices, including stent-grafts and all similar implants, should eventually change direction to advanced manufacturing techniques. It is expected that through recent advancements, especially the emergence of 4D-printing and smart materials, unprecedented features can be defined for cardiovascular medical implants, like shape change and remote battery-free self-monitoring. 4D-printing technology promises adaptive functionality, a highly desirable feature enabling printed cardiovascular implants to physically transform with time to perform a programmed task. This review provides a thorough assessment of the established technologies for existing stent-grafts and provides technical commentaries on known failure modes. They then discuss the future of advanced technologies and the efforts needed to produce next-generation endovascular implants.

show abstract

Composite polymer/wax coatings as a corrosion barrier of bioresorbable magnesium coronary stents

Andreeva,

Walker,

Rudt

et al. 2024

Heliyon

View full text Add to dashboard Cite

Evaluation of Biodegradable Stent Graft Coatings in Pig and Rabbit Models

Cited by 3 publications

References 24 publications

A preclinical animal model for evaluating the sealing capacity of covered stent grafts in acute vessel perforation

A preclinical animal model for evaluating the sealing capacity of covered stent grafts in acute vessel perforation

The Technological Advancement to Engineer Next‐Generation Stent‐Grafts: Design, Material, and Fabrication Techniques

Composite polymer/wax coatings as a corrosion barrier of bioresorbable magnesium coronary stents

Contact Info

Product

Resources

About