Evaluation of biodegradable polyester-co-lactone microparticles for protein delivery

Tawfeek, Hesham M.; Khidr, S. H.; Samy, E.; Ahmed, Sayed M.; Gaskell, Elsie E.; Hutcheon, Gillian A.

doi:10.3109/03639045.2013.814060

Cited by 4 publications

(7 citation statements)

References 53 publications

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“…2; Trace C). In addition, the reduced PGA-co-PDL peaks intensities was attributed to the processing steps and was also reported in our previous study using PGA-co-PDL encapsulated α-chymotrypsin and with PLGA nanoparticles entrapped cyclosporine (Tawfeek et al, 2014;Wagh and Apar, 2014). PGA-co-PDL/Eudragit MPs loaded IND (1:1.5 wt/wt ratio) showed complete disappearance of PGA-co-PDL characteristic peaks ( Fig.1; Trace D) which was attributed to the efficient coating of Eudragit L-100-55 around PGA-co-PDL particles.…”

Section: Pga-co-pdl Microparticle/eudragit Characterisationsupporting

confidence: 86%

“…5C). Similar results have been reported by Tawfeek et al (Tawfeek et al, 2014), using high concentrations of SSG in FDTs containing itopride HCl significantly decreased the in vitro disintegration time (Tawfeek et al, 2015). Hence, it could be concluded that formulation 12SSG-5CF was considered an optimum formulation in terms of in vitro disintegration time as stated in the optimum time for disintegration for orodispersible tablets in European Pharmacopeia (pharmacopoeia, 2002).…”

Section: Optimizing the Fdtssupporting

confidence: 84%

“…PGA-co-PDL polymer showed the characteristic melting broad peak at 57.12 °C, indicating the outlet temperature of spray dryer did not exceed the low melting of the polymer (Tawfeek et al, 2011b). PGA-co-PDL showed an area under the endothermic peak of 269.04 mJ and heat of fusion (ΔH) of 60.59 J/gas as previously reported (Tawfeek et al, 2014). Moreover, Eudragit L100-55 (Fig 2; Trace B) showed two very broad endothermic peaks at 70.14 and 209.84 °C.…”

Section: Pga-co-pdl Microparticle/eudragit Characterisationsupporting

confidence: 80%

“…Similar studies have reported low IND loading in microspheres (5.7 µg/mg particles) used for colon targeting prepared via spray drying (Jain et al, 2014;Lee et al, 2004) (Corrigan and Li, 2009). Moreover, the degree of polymer crystallinity affects the encapsulation efficiency, hence drugs will be encapsulated in the amorphous region of the semi crystalline PGA-co-PDL (Kim et al, 2005;Tawfeek et al, 2014). PGA-co-PDL/Eudragit MPs were efficiently prepared via spray drying with yields of (40.74±5.5, 43.33±4.3 and 55.7±6.7 % for 1:0.5; 1:1 and 1:1.5 PGA-co-PDL to Eudragit L100-55 weight ratios; respectively), which was similar to our previous reports (Tawfeek et al, 2011a).…”

Section: Pga-co-pdl Microparticle Preparationsmentioning

confidence: 71%

“…Poly(glycerol-adipate-co-ɷ-pentadecalactone), PGA-co-PDL, is biodegradable polyester studied as a carrier for small and large molecular weight compounds ( (Tawfeek et al, 2014;Alfagih et al, 2015;Kunda et al, 2015a;Kunda et al, 2015b;Kunda et al, 2015c;Tawfeek et al, 2011a;Tawfeek et al, 2013)). Fast disintegrating tablets, FDTs, or orodispersible tablets are intended for administration to patients with difficulty in swallowing, such as the elderly and paediatric patients.…”

Section: Introductionmentioning

confidence: 99%

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Colonic delivery of indometacin loaded PGA-co-PDL microparticles coated with Eudragit L100-55 from fast disintegrating tablets

Tawfeek

Abdellatif

Dennison

et al. 2017

International Journal of Pharmaceutics

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The aim of this work was to investigate the efficient targeting and delivery of indometacin (IND), as a model anti-inflammatory drug to the colon for treatment of inflammatory bowel disease. We prepared fast disintegrating tablets (FDT) containing IND encapsulated within poly(glycerol-adipate-co-ɷ-pentadecalactone), PGA-co-PDL, microparticles and coated with Eudragit L100-55 at different ratios (1:1.5, 1:1, 1:0.5). Microparticles encapsulated with IND were prepared using an o/w single emulsion solvent evaporation technique and coated with Eudragit L-100-55 via spray drying. The produced coated microparticles (PGA-co-PDL-IND/Eudragit) were formulated into optimised FTD using a single station press. The loading, in vitro release, permeability and transport of IND from PGA-co-PDL-IND/Eudragit microparticles was studied in Caco-2 cell lines. IND was efficiently encapsulated (570.15±4.2μg/mg) within the PGA-co-PDL microparticles. In vitro release of PGA-co-PDL-IND/Eudragit microparticles (1:1.5) showed significantly (p<0.05, ANOVA/Tukey) lower release of IND 13.70±1.6 and 56.46±3.8% compared with 1:1 (89.61±2.5, 80.13±2.6%) and 1:0.5 (39.46±0.9 & 43.38±3.12) after 3 and 43h at pH 5.5 and 6.8, respectively. The permeability and transport studies indicated IND released from PGA-co-PDL-IND/Eudragit microparticles had a lower permeability coefficient of 13.95±0.68×10cm/s compared to free IND 23.06±3.56×10cm/s. These results indicate the possibility of targeting anti-inflammatory drugs to the colon using FDTs containing microparticles coated with Eudragit.

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Section: Pga-co-pdl Microparticle/eudragit Characterisationsupporting

confidence: 86%

Section: Optimizing the Fdtssupporting

confidence: 84%

Section: Pga-co-pdl Microparticle/eudragit Characterisationsupporting

confidence: 80%

Section: Pga-co-pdl Microparticle Preparationsmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

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Colonic delivery of indometacin loaded PGA-co-PDL microparticles coated with Eudragit L100-55 from fast disintegrating tablets

Tawfeek

Abdellatif

Dennison

et al. 2017

International Journal of Pharmaceutics

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Polymers from macrolactones: From pheromones to functional materials

Wilson

Ateş

Pflughaupt

et al. 2019

Progress in Polymer Science

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Lipase-catalyzed synthesis of poly(ω-pentadecalactone-co-globalide) in supercritical carbon dioxide

Santos,

Rebelatto,

Guindani

et al. 2025

The Journal of Supercritical Fluids

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Evaluation of biodegradable polyester-co-lactone microparticles for protein delivery

Cited by 4 publications

References 53 publications

Colonic delivery of indometacin loaded PGA-co-PDL microparticles coated with Eudragit L100-55 from fast disintegrating tablets

Colonic delivery of indometacin loaded PGA-co-PDL microparticles coated with Eudragit L100-55 from fast disintegrating tablets

Polymers from macrolactones: From pheromones to functional materials

Lipase-catalyzed synthesis of poly(ω-pentadecalactone-co-globalide) in supercritical carbon dioxide

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