Evaluation of biodegradable paclitaxel-eluting nanofibre-covered metal stents for the treatment of benign cardia stricture in an experimental model

Zhang, Donghui; Cui, Wenguo; Cheng, Ying-Sheng; Chang, Jiang; Chen, N.-W.; Yan, Long

doi:10.1002/bjs.9106

Cited by 19 publications

(11 citation statements)

References 34 publications

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“…Theoretically, localized delivery of drugs such as paclitaxel or rapamycin from drug-eluting stents is a promising treatment method for preventing restenosis or inflammatory cell proliferation. Until now, many experimental studies have been done with animal models 42,43. More studies on the clinical application of drug-eluting BD stents for human patients are needed.…”

Section: Biodegradable Stentmentioning

confidence: 99%

Plastic and Biodegradable Stents for Complex and Refractory Benign Esophageal Strictures

Ham

Kim

2014

Clin Endosc

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Endoscopic stent placement is a well-accepted and effective alternative treatment modality for complex and refractory esophageal strictures. Among the currently available types of stents, the partially covered self-expanding metal stent (SEMS) has a firm anchoring effect, preventing stent migration and ensuring effective covering of a narrowed segment. However, hyperplastic tissue reaction driven by the uncovered mesh may prevent easy and safe stent removal. As an alternative, a fully covered SEMS decreases the recurrence of dysphagia caused by hyperplastic tissue ingrowth; however, it has a high migration rate. Likewise, although a self-expanding plastic stent (SEPS) reduces reactive hyperplasia, the long-term outcome is disappointing because of the high rate of stent migration. A biodegradable stent has the main benefit of not requiring stent removal in comparison with SEMS and SEPS. However, it still has a somewhat high rate of hyperplastic reaction, and the long-term outcome does not satisfy expectations. Up to now, the question of which type of stent should be recommended for the effective treatment of complex and refractory benign strictures has no clear answer. Therefore, the selection of stent type for endoscopic treatment should be individualized, taking into consideration the endoscopist's experience as well as patient and stricture characteristics.

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Section: Biodegradable Stentmentioning

confidence: 99%

Plastic and Biodegradable Stents for Complex and Refractory Benign Esophageal Strictures

Ham

Kim

2014

Clin Endosc

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“…To prevent this development, drug-eluting (such as rapamycin and paclitaxel) stents have been evaluated. 28 In this study, mild mucosal hypertrophy occurred in all patients, except 1, whose mucosal hypertrophy was excessive and appeared as pseudopolyps; fortunately, the condition did not have clinical consequences. Thoracic pain, the sensation of having a foreign object in the body, perforation, and bleeding are other complications of BS placement.…”

Section: Discussionmentioning

confidence: 48%

Self-Expanding Biodegradable Stents for Postoperative Upper Gastrointestinal Issues

Köneş

Oran

2018

JSLS

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Background and Objectives:Endoscopic stenting is a minimally invasive treatment modality for patients with various gastrointestinal conditions. We evaluated the safety and efficacy of uncovered biodegradable stents for postoperative leaks and strictures in the upper gastrointestinal tract.Methods:This was a retrospective study of patients treated endoscopically with biodegradable stents from January 2010 through November 2017.Results:Thirteen patients were enrolled, 7 of whom were men. Their mean age was 46 (range, 21–82) years. The indications for stent placement were postoperative leakage and stricture in 9 and 4 patients, respectively. The primary diagnoses were obesity in 7 patients, gastric cancer in 5, and peptic ulcer in 1. The average time to stent placement after surgery was 35 (range, 17–125) and 166 (range, 153–185) days for patients with postoperative leakage and stricture, respectively. Stent insertion was successful at the first attempt in all patients. Complete resolution of the leak and stricture was achieved after stent application in 11 patients, for a clinical success rate of 85%. The mean follow-up duration was 50 (range, 24–76) months. There were no major complications.Conclusions:Compared to self-expanding metal and plastic stents, the main advantages of uncovered biodegradable stents are that they do not have to be removed and have a low migration rate. Our results suggest that these stents have promise for management of postoperative gastrointestinal complications. Further randomized trials with larger sample sizes are necessary to determine the role of biodegradable stents in the treatment algorithm.

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“…It should be noted that alignment of respective nanofibers could not be observed because we rotated the electrospinning collector at a low speed (<250 rpm) to minimize the alignments of the nanofibers in Figure (B). In the previous study, we aligned the nanofibers at increasing speed of the rotating collector to create topological cues on the nanofibrous meshes . The unique nanotopographical cues were further employed to differentiate the mesenchymal stems cells into neuronal lineages; however, in this study, the aligned structures of the nanofiber are required to be undesirable because the coated nanofibrous meshes should be extended according the extension of metallic stents.…”

Section: Resultsmentioning

confidence: 99%

Multilayered electrospun fibrous meshes for restenosis-suppressing metallic stents

Son

Kim

Choi

et al. 2015

J. Biomed. Mater. Res.

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Nanofiber is a flexible and highly porous mesh that is advantageous for coating bare metal stent and local drug delivery. Herein, we developed drug‐eluting stent coated with PCL/PU blending coaxial nanofiber for controlling drug release manner and suppressing in‐stent restenosis, which is a representative side effect of stenting surgery. The shell of coaxial electrospun nanofibrous are composed of poly (ε‐caprolactone) (PCL) and polyurethane (PU) for biodegradability and elasticity to the polymeric coating of stent. Paclitaxel (PTX) is loaded into both the core and shell through electrospinning using coaxial nozzle with different weight ratio. The morphology of nanofiber‐coated stent, expansion state, and core/shell structure of nanofiber were visualized by scanning electron microscope and transmission electron microscope. As more amount of PCL/PU was infused from the outer nozzle, PTX release speed from the nanofiber was increased. And PTX suppressed L6 cell proliferation in vitro expecting potential possibility of PTX‐loaded coaxial nanofiber as a drug‐eluting stent coating material. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 628–635, 2017.

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Evaluation of biodegradable paclitaxel-eluting nanofibre-covered metal stents for the treatment of benign cardia stricture in an experimental model

Abstract: The DES was more effective for the treatment of benign cardia stricture than bare stents in a canine model. Retention of the DES for 4 weeks led to a better clinical and pathological outcome than 1 week.

Cited by 19 publications

References 34 publications

Plastic and Biodegradable Stents for Complex and Refractory Benign Esophageal Strictures

Plastic and Biodegradable Stents for Complex and Refractory Benign Esophageal Strictures

Self-Expanding Biodegradable Stents for Postoperative Upper Gastrointestinal Issues

Multilayered electrospun fibrous meshes for restenosis-suppressing metallic stents

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