Evaluation of Biocompatible Films Using Copolymers of N‐Vinylbenzamide with Cationic Moieties by Hydrolysis of N‐Vinylformamide

Abstract

Biocompatible materials using poly(N-vinylamide) derivatives are developed via a recently designed synthetic route. N-Vinylbenzamide (NVB) is synthesized as typical hydrophilic N-vinylamide monomer, then copolymerized with N-vinylformamide (NVF) by free radical polymerization, which can convert to cationic polyvinylamine unit by hydrolysis. Cell toxicity on the surface of copolymer films is investigated, revealing that poly(N-vinylamide) derivatives show biocompatibility regardless of the cationic ratio.