Evaluation of biocompatibility of Targis Dentin and Artglass by using subcutaneous implantation test

Sonmez, Nalan Sule; Sönmez, Erhan; Akçaboy, Cihan

doi:10.4103/0970-9290.74211

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…However, the samples showing moderate reactions in both periods are considered to fail the test. Although there is no reaction or moderate reaction at week 2, it is considered that the material fails the test if it is moderate or severe at the end of week 12 [17]. Based on these criteria, it can be said that all the universal adhesives have passed the biocompatibility test when the results of our study are examined.…”

Section: Resultsmentioning

confidence: 99%

“…It has been stated that local inflammation and toxicities could be determined through the implantation of DMs into the subcutaneous connective tissue in experimental animals. Since the resulting inflammatory tissue response is similar to that of exposed pulp and connective tissue, subcutaneous implantation tests are considered as a reliable method for assessing the biocompatibility of DMs [17]. It is known that subcutaneous implantation tests generally consider day 7, 30 and 90 as experimental periods.…”

Section: Resultsmentioning

confidence: 99%

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Biocompatibility of Different Universal Adhesives During Short and Long Periods on Rat Model

Ünal

Saygın

Koç

et al. 2021

J. Photopol. Sci. Technol.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Biocompatibility of Different Universal Adhesives During Short and Long Periods on Rat Model

Ünal

Saygın

Koç

et al. 2021

J. Photopol. Sci. Technol.

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“…It has been stated that local inflammation and toxicities can be determined by implantation of dental materials into subcutaneous connective tissue in experimental animals. Since the inflammatory tissue response after subcutaneous implantation tests is similar to pulp and connective tissue, it is considered a reliable method to evaluate the biocompatibility of dental materials ( 23 ). Since PTs are inert in subcutaneous implantation tests, materials are placed in these tubes and their biocompatibility is evaluated ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility of different resin composites after polymerization with two light curing units: an immunohistochemical study

İpek¹,

Ünal²,

Koç³

2023

eor

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Purpose: The aim of this study is to compare the biocompatibility of two different resin composites after polymerization under two different light sources in three different time periods. Materials and methods: 72 polyethylene tubes polymerized with 2 different resin composites and 2 different light sources (Elipar S10 and Valo ) [Group 1: Kalore Elipar S10 (KE), Group 2: Kalore Valo (KV), Group 3: Essentia Elipar S10 (EE), Group 4: Essentia Valo (EV)] were implanted in the dorsal connective tissue of 18 rats. 24 empty polyethylene tubes [Group 5: (Control group)] were implanted in the dorsal connective tissue of 6 rats. Then, the rats were sacrificed after 7th, 15th and 30th days in each time intervals (n=8). Biopsy samples were stained with H&E and examined for inflammation, necrosis, macrophage infiltrate, giant cell and fibrous capsule criteria. Immunohistochemical staining was performed to evaluate proinflammatory cytokines (IL-1β, IL-6 and IL-8). Results: When the composite groups and the control groups were compared; the difference was statistically significant for the criteria of inflammation at 7th and 15th days, there was no statistical difference between the time points in terms of fibrous capsule and necrosis. When the composite groups and control groups were evaluated in terms of proinflammatory cytokines; statistically significant differences were found at 7th, 15th and 30th days. Conclusion: All CRs used in this study showed acceptable biocompatibility in the subcutaneous tissues of rats after polymerization with different light sources.

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“…This mild inflammatory reaction probably originated from the surgical trauma. 50 On the other hand, Group III displayed fibrous connective tissue formation with thick collagen fibers and few fibroblasts. Macrophage/multinucleated giant cells were more evident adjacent to Group III tubes than other groups ( Figure 2C).…”

Section: In Vivo Biocompatibility Studymentioning

confidence: 97%

<p>Egyptian Propolis-Loaded Nanoparticles as a Root Canal Nanosealer: Sealing Ability and in vivo Biocompatibility</p>

Raheem¹,

Razek²,

Elgendy³

et al. 2020

IJN

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Background: Successful endodontic therapy is mainly governed by the satisfactory sealing ability of the applied root canal sealer. Also, tolerability of root canal structure to accommodate the presence of a sealer participates in the efficiency of the treatment. Hence, this study was aimed to extrapolate our previous one that was concerned with the preparation and evaluation of novel nature-based root canal sealers. Our current work is focused on the evaluation of sealing ability and in vivo biocompatibility. Materials and Methods: Egyptian propolis was extracted (ProE) and encapsulated in polymeric nanoparticles (ProE-loaded NPs). Two root sealers, PE sealer and PE nanosealer, were fabricated by incorporating ProE and ProE-loaded NPs, respectively. The sealing ability of the developed sealers was tested by a dye extraction method. An in vivo biocompatibility study was conducted using a subcutaneous implantation method for two and four weeks. At the same time, a model sealer (AH Plus®) was subjected to the same procedures to enable accurate and equitable results. Results: The teeth treated with PE sealer exhibited weak sealing ability which did not differ from that of unfilled teeth. PE nanosealer enhanced the sealing ability similarly to the model sealer with minimal apical microleakage. Studying in vivo biocompatibility indicated the capability of the three tested sealers to induce cell proliferation and tissue healing. However, PE nanosealer had superior biocompatibility, with higher potential for cell regeneration and tissue proliferation. Conclusion: PE nanosealer can be presented as an innovative root canal sealer, with enhanced sealing ability as well as in vivo biocompatibility. It can be applied as a substitute for the currently available sealers that demonstrate hazardous effects.

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Evaluation of biocompatibility of Targis Dentin and Artglass by using subcutaneous implantation test

Abstract: At the end of the study, according to the FDI and ISO-7405 standards, Targis and Artglass indicated biocompatibility with the subcutaneous connective tissue of the rat.

Cited by 5 publications

References 4 publications

Biocompatibility of Different Universal Adhesives During Short and Long Periods on Rat Model

Biocompatibility of Different Universal Adhesives During Short and Long Periods on Rat Model

Biocompatibility of different resin composites after polymerization with two light curing units: an immunohistochemical study

<p>Egyptian Propolis-Loaded Nanoparticles as a Root Canal Nanosealer: Sealing Ability and in vivo Biocompatibility</p>

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