Evaluation of biochemical effects related to perfluorooctane sulfonic acid exposure in organohalogen-contaminated great tit (Parus major) and blue tit (Parus caeruleus) nestlings

Hoff, Philippe Tony; Vijver, Kristin Van de; Dauwe, Tom; Covaci, Adrian; Maervoet, J.; Eens, Marcel; Blust, Ronny; Coen, Wim De

doi:10.1016/j.chemosphere.2005.04.109

Cited by 51 publications

(42 citation statements)

References 32 publications

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“…However, increasing blood plasma concentrations of liver enzymes may also be a result of e.g., hypoxia, inflammation, diet, infection, neoplasia, trauma, metabolic abnormalities (storage diseases), endocrine diseases and/or hepatocyte regeneration (Ettinger and Feldman, 1995;Thrall et al, 2006). Previous studies have shown that PFOS and PFOA increase blood plasma concentrations of ALAT (Hoff et al, 2005;Yahia et al, 2010). This is not in accordance with our findings in white-tailed eagles, indicating that the relationship between BCCPs and OHCs are not always obvious and that studies like the present are not designed to pinpoint cause-and-effect relationships.…”

Section: Relationships Between Ohcs and Bccpscontrasting

confidence: 99%

Blood plasma clinical–chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings

Sonne

Bustnes

Herzke

et al. 2012

Ecotoxicology and Environmental Safety

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Raptors are exposed to biomagnifying and toxic organohalogenated compounds (OHCs) such as organochlorines, brominated flame retardants and perfluorinated compounds. To investigate how OHC exposure may affect biochemical pathways we collected blood plasma from Norwegian northern goshawk (n=56), golden eagle (n=12) and white-tailed eagle (n=36) nestlings during three consecutive breeding seasons. We found that blood plasma concentrations of calcium, sodium, creatinine, cholesterol, albumin, total protein, urea, inorganic phosphate, protein:creatinine, urea:creatinine and uric acid:creatinine ratios and liver enzymes ALKP and ALAT were positively correlated to PCBs, chlordanes, p,p'-DDE, HCB, PFCs and/or PBDEs. Total bilirubin and glucose were negatively correlated to PCBs while magnesium and potassium were negatively correlated to HCB and p,p'-DDE. In addition, protein:creatinine and ALAT were also negatively correlated to PCBs and PFCs, respectively. The most significant relationships were found for the highly contaminated northern goshawks and white-tailed eagles. The statistical relationships between OHCs and BCCPs indicate that biochemical pathways could be influenced while it is uncertain if such changes have any health effects. The OHC concentrations were below concentrations causing reproductive toxicity in adults of other raptor species but similar to those of concern for endocrine disruption of thyroid hormones in e.g., bald eagles.

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Section: Relationships Between Ohcs and Bccpscontrasting

confidence: 99%

Blood plasma clinical–chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings

Sonne

Bustnes

Herzke

et al. 2012

Ecotoxicology and Environmental Safety

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“…In most biota, PCB is the dominating chlorinated pollutant, but in livers of songbirds and freshwater fish from Belgium [19,20] and in plasma from sea turtles on the east coast of North America [21], PFOS concentrations were several‐fold higher than ΣPCB. Also, in Arctic mammals, such as mink ( Mustela vison ), Arctic fox ( Alopex lagopus ), and polar bear ( Ursus maritimus ), PFOS concentrations have been high compared to ΣPCB [3,18,38].…”

Section: Discussionmentioning

confidence: 99%

“…Whereas the concentrations of most legacy OCs, such as polychlorinated biphenyls (PCBs) and OC pesticides, have decreased over the last three decades [13,14], those of PFCs and PBDEs have increased in many environments, including remote areas such as the Arctic [2,[15][16][17][18]. Recently, some studies have found levels of PFCs as high as those of legacy OCs in different biota [3,[19][20][21]. Little, however, is known about how the dif-ferent compounds are distributed among individuals within populations and what factors influence the distribution.…”

Section: Introductionmentioning

confidence: 99%

Perfluorinated, brominated, and chlorinated contaminants in a population of lesser black‐backed gulls (Larus fuscus)

Bustnes

Borgå

Erikstad

et al. 2008

Enviro Toxic and Chemistry

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Protein-bound perfluorinated compounds (PFCs) and lipid-soluble polybrominated diphenyl ethers (PBDEs) and organochlorines (OCs) were measured in whole blood from a large number (n = 83) of breeding lesser black-backed gulls (Larus fuscus) caught during two distinct sampling periods in a colony on the coast of northern Norway. We analyzed 14 PFCs (seven were detected in more than 75% of samples), 10 PBDEs (only BDE 47 was detected), and 27 OCs, including 12 polychlorinated biphenyl (PCB) congeners (14 OCs were detected). Median total PFC concentration was higher than median total OC concentration (43 vs 39 ng/g wet wt). Perfluorooctane sulfonate (PFOS) was the dominant PFC (mean relative contribution of PFOS to total contaminant concentration in blood [Sigmatotal contaminants] was 38%), whereas total PCB (26% of Sigmatotal contaminants) and p,p'-DDE (2,2-bis(4-chlorophenyl)-1,1-dichloroethene; 13% of Sigmatotal contaminants) were the dominant OCs. No covariability was found between protein-bound and lipid-soluble compounds; individuals with high concentrations of PFCs did not have high concentrations of OCs or BDE 47. The concentrations of PFCs were lower in birds caught during the late sampling period compared to those of the early period, and females had lower levels of some PFCs compared with males, suggesting that females sequester fluorinated substances into eggs. For lipid-soluble compounds, no significant sex or sampling period differences were found, except that trans-nonachlor, cis-nonachlor, and p,p'-DDE concentrations were lower in birds caught during the late sampling period. The pattern of PFC compounds (relative to PFOS) and lipid-soluble compounds (relative to PCB 153) differed between sampling periods in females but not in males. Finally, PFCs were distributed more uniformly within the population than the lipid-soluble compounds, for which the distributions were strongly negatively skewed.

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“…Concentrations of both PBDEs [12,13] and perfluorinated compounds [14,15] have now been documented in biota, including birds; and reproductive and physiological effects have been reported in birds for both PBDEs [16,17] and perfluorinated compounds [18][19][20]. Exposure to these chemicals of concerns, however, needs to be quantified and accounted for so that effects of the listed contaminants can be correctly assessed, especially for bird or animal deformities and reproductive problems beneficial use impairment.…”

Section: Introductionmentioning

confidence: 99%

“…Exposure to these chemicals of concerns, however, needs to be quantified and accounted for so that effects of the listed contaminants can be correctly assessed, especially for bird or animal deformities and reproductive problems beneficial use impairment. Concentrations of both PBDEs [12,13] and perfluorinated compounds [14,15] have now been documented in biota, including birds; and reproductive and physiological effects have been reported in birds for both PBDEs [16,17] and perfluorinated compounds [18][19][20]. Comparative ranking among AOCs for PBDEs was recently reported for tree swallow eggs [4] but not for perfluorinated compounds.…”

Section: Introductionmentioning

confidence: 99%

Organic contamination in tree swallow (Tachycineta bicolor) nestlings at United States and binational Great Lakes Areas of Concern

Custer

Dummer

et al. 2016

Enviro Toxic and Chemistry

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Contaminant exposure of tree swallows, Tachycineta bicolor, nesting in 27 Areas of Concern (AOCs) in the Great Lakes basin was assessed from 2010 to 2014 to assist managers and regulators in their assessments of Great Lakes AOCs. Contaminant concentrations in nestlings from AOCs were compared with those in nestlings from nearby non-AOC sites. Polychlorinated biphenyl (PCB) and polybrominated diphenyl ether concentrations in tree swallow nestling carcasses at 30% and 33% of AOCs, respectively, were below the mean concentration for non-AOCs. Polycyclic aromatic hydrocarbon (PAH) concentrations in nestling stomach contents and perfluorinated compound concentrations in nestling plasma at 67% and 64% of AOCs, respectively, were below the mean concentration for non-AOCs. Concentrations of PCBs in nestling carcasses were elevated at some AOCs but modest compared with highly PCB-contaminated sites where reproductive effects have been documented. Concentrations of PAHs in diet were sufficiently elevated at some AOCs to elicit a measurable physiological response. Among AOCs, concentrations of the perfluorinated compound perfluorooctane sulfonate in plasma were the highest on the River Raisin (MI, USA; geometric mean 330 ng/mL) but well below an estimated toxicity reference value (1700 ng/mL). Both PAH and PCB concentrations in nestling stomach contents and PCBs in carcasses were significantly correlated with concentrations in sediment previously reported, thereby reinforcing the utility of tree swallows to assess bioavailability of sediment contamination. Environ Toxicol Chem 2017;36:735-748. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.

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Evaluation of biochemical effects related to perfluorooctane sulfonic acid exposure in organohalogen-contaminated great tit (Parus major) and blue tit (Parus caeruleus) nestlings

Cited by 51 publications

References 32 publications

Blood plasma clinical–chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings

Blood plasma clinical–chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings

Perfluorinated, brominated, and chlorinated contaminants in a population of lesser black‐backed gulls (Larus fuscus)

Organic contamination in tree swallow (Tachycineta bicolor) nestlings at United States and binational Great Lakes Areas of Concern

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