Evaluation of biochemical constituents and inhibitory effect of tea clone 100 on colorectal cancer cell line HCT- 116

Bondarian, Fereydoon; Ebrahimi, Asa; Mahjoubi, Frouzandeh; Hervan, Eslam Majidi; Gonbad, Reza Azadi

doi:10.4314/tjpr.v17i6.8

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Therefore, exploring low-toxic and highly effective natural ingredients with favorable biocompatibility is keenly desired and has become a hot topic in the development of anticolon cancer agents in recent years. More importantly, the bioactive components of tea with good biocompatibility have been revealed to possess an inhibitory effect on the proliferation of colon cancer cells and can serve as potential anticolon cancer drugs. , It has been reported that black tea also showed anticolon cancer ability, which may be attributed to the presence of TFs, its main bioactive components . However, despite the potential applications of TFs in pharmacology, the comparison between the four TFs in antioxidant and anticolon activities caused by their structural distinctions was rarely studied and reported.…”

Section: Introductionmentioning

confidence: 99%

Structure–Activity Relationship Analysis on Antioxidant and Anticancer Actions of Theaflavins on Human Colon Cancer Cells

Tan¹,

Peng

Huang³

et al. 2018

J. Agric. Food Chem.

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The roles of natural products as effective cancer prevention and therapeutic agents have been documented by various studies in recent years, but the action mechanisms and structure−activity relationship need more elucidation. The present study showed that theaflavins (theaflavin and its derivatives, TFs) from black tea caused an inhibitory effect on the proliferation of human colon adenocarcinoma cancer SW480 cells and human colon cancer SW620 cells [half maximal inhibitory concentration (IC 50 ) < 32.0 μM] by the induction of cell cycle arrest but exerted lower toxicity against normal cells with a high safety index (1.89−6.26). Moreover, TFs triggered a decrease in reactive oxygen species in SW480 cells as a result of their excellent radical-scavenging ability (e.g., the IC 50 value of TF4 to ABTS • + was 1.91 ± 0.21 μM). More importantly, the structure−activity relationship analysis of TFs exhibited that the galloyl group was an important factor to affect these activities. Taken together, we revealed that the TFs could act as substitutes for natural antioxidants and promising anticancer agents with beneficial influence on human health and then anticipated that this study may provide useful information on the development of therapeutic natural products.

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Section: Introductionmentioning

confidence: 99%

Structure–Activity Relationship Analysis on Antioxidant and Anticancer Actions of Theaflavins on Human Colon Cancer Cells

Tan¹,

Peng

Huang³

et al. 2018

J. Agric. Food Chem.

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“…Catechins are the major compounds in C. sinensis, their amount depends on the different fermentation stages and the highest catechin amount is in white tea because it is not fermented during preparation (12,15,22). A similar result in a study conducted by Bondarian et al proved that the highest amount of polyphenols (catechins) was yielded in white tea (23).…”

Section: Discussionmentioning

confidence: 60%

Catechic Tannin Content of Different Tea Samples

Toraman¹,

Tan²

2022

jarhs

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Objective: Camellia sinensis (tea) which is a member of the Theaceae family can be found in many tropical and subtropical areas with diverse cultural forms. It is grown only in the Eastern Black Sea Region of Turkey and originated from China and Japan and is defined as a small evergreen tree. White, green, and black teas are all made from the Camellia sinensis plant species. Scientific studies have shown that distinct types of tea have emerged because of different fermentation processes in the production stages. In this study, the macroscopic and microscopic analysis, diagnosis of tannin, and catechical tannin determination have been conducted on fifteen Camellia sinensis samples purchased from various places. Material and Methods: Five grams of powdered tea samples were extracted with 50 ml of hot water and the catechical tannin determination in the extracts was made by gelatin, ferric and stiasny tests. Results: In the macroscopical examination of A-E (white, green, and black) tea samples the researchers observed no color, odor, or any other substance. When all the samples were microscopically examined, reaserch detected the presence of idioblast which is the characteristic structure of the tea. Conclusion: There was a positive result regarding a diagnosis of tannin and catechical tannin.

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Biological Activities and Polyphenol Content of Qi Cha Tea®, a Functional Beverage of White Tea Containing Botanicals and Dry Botanical Extracts with European Health Claims

Maixent,

Belaiba,

Pons

et al. 2023

Plants

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Infusions of Camellia sinensis leaves have been known for their health benefits. The Bio Concentrate Assets® (ABC) method is a method of enriching organic infusion leaves (from Camellia sinensis) with organic dry and concentrated extracts using organic acacia gum, and its application to white tea has provided Qi cha tea®. In the present study, the content of tea polyphenols and caffeine, and the biochemical properties of Qi cha tea® and its botanical constituents (elderberry, tulsi, Echinacea purpurea, orange peel, lemongrass, and acacia gum) were assessed. Antioxidant and cell viability activities were determined by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay and MTT (3-(4, 5-dimethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide) assay in human Caco-2 and HCT-116 cell lines, and ascorbic acid and tamoxifen, respectively. The caffeine and polyphenol composition of Qi cha tea® was modified with less caffeine and gallic acid and more epigallocatechin gallate (EGCG) than the original white tea. The majority of the tested botanical samples including Qi cha tea® at 50 µg/mL show similar antioxidant activities, with the exception of Echinacea purpurea. The greatest effect was found for white tea. The antioxidant power of the Qi cha tea® (90% at 50 µg/mL for pressurized liquid extraction (PLE) was divided by approximately a factor of two (61% at 50 µg/mL for pressurized liquid extraction products (PLEP)), which corresponds to the 48.3% (mass/mass) white tea original content in the Qi cha tea®. Qi cha tea® shows the lowest cytotoxic activity in the viability of the two cell lines when compared to white tea. The application of the ABC method to Qi cha tea® using various botanicals and dry extract with acacia gum as blinder has allowed the development of a new innovative functional health beverage that complies with European health claims.

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Evaluation of biochemical constituents and inhibitory effect of tea clone 100 on colorectal cancer cell line HCT- 116

Cited by 3 publications

References 20 publications

Structure–Activity Relationship Analysis on Antioxidant and Anticancer Actions of Theaflavins on Human Colon Cancer Cells

Structure–Activity Relationship Analysis on Antioxidant and Anticancer Actions of Theaflavins on Human Colon Cancer Cells

Catechic Tannin Content of Different Tea Samples

Biological Activities and Polyphenol Content of Qi Cha Tea®, a Functional Beverage of White Tea Containing Botanicals and Dry Botanical Extracts with European Health Claims

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