Evaluation of biochemical assays and optimization of LC–MS-MS analysis for the detection of synthetic urine
Laura Franke,
Christian Fuczik,
Michael Hubig
et al.
Abstract:Ensuring specimen validity is an essential aspect of toxicological laboratories. In recent years, substituting authentic urine specimens for synthetic urine (SU) has become increasingly popular. Such SU products consist of components expected in normal urine and show physiological values for specific gravity and pH. Thus, standard specimen validity testing may fail in revealing adulteration by SU. The present study investigated three methods to distinguish authentic and SU specimens: enzymatic detection of uri… Show more
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