Evaluation of betulin for hair growth promoting activity in rats

Abstract

Hair has historically been associated with beauty and a person's unique personality. Numerous elements, including metabolism, hormones, inheritance, and the adverse effects of immunosuppressive and anti-neoplastic medications, can adversely impact hair health and lead to hair loss, or alopecia. It is typical everywhere in the world.The current study examined the effect of betulin for hair growth promoting activity in rats.The study used 48 albino wistar rats, weighing 200 ± 30 grams and aged between 12 and 16 months. Testosterone was given at a dose of 0.5 mg/kg to induce hair loss. During 28 days, a once-daily topical application of minoxidil solution was made. On a daily basis for 28 days, betulin was administered orally at concentrations of 10 mg/kg, 20 mg/kg, and 40 mg/kg. A combination of Betulin (10 mg/kg p.o.) and 3% Minoxidil was administered to one group, while the other was treated with Topical Betulin Solution (3 mg/ml once daily for 28 days). ANOVA analysis was used to ascertain the data's statistic.The results showed that effect of Betulin on Alopecia as evidenced by decreased levels of cholesterol, testosterone and increased levels of Hair length.According to the current study, albino wistar rats with Testosterone induced Alopecia can benefit from treatment with an Betulin.