Evaluation of beta-endorphin/beta-lipotropin immunoreactivity content in the CSF of patients affected by deafferentation pain syndromes

Salar, G; Alessio, L; Govoni, Stefano; Battaini, F.; I, Iob; Goss, I; Trabucchi, M.

doi:10.1016/s1043-6618(05)80120-3

Cited by 10 publications

(1 citation statement)

References 23 publications

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“…Furthermore, the endorphin-like immunoreactivity in the cerebrospinal fluid was lower in the patients with neuropathic pain than in those experiencing other kinds of pain [47]. On the other hand, no significant variation in the levels of β-endorphin was found in patients suffering from deafferentation pain [48].…”

Section: Opioids Systems In Nociception and Neuropathic Pain εNdorphinsmentioning

confidence: 84%

Opioids in Neuropathic Pain

Przewłocki

Przewłocka

2005

CPD

108

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Opiates lack potent analgesic efficacy in neuropathic pain although it is now generally accepted that the poor effect of these drugs reflects a reduction in their potency. Reduction of morphine antinociceptive potency was postulated to be due to the fact that nerve injury altered the activity of opioid systems or opioid specific signaling. Endogenous opioid systems were found to be represented in the regions involved in the nociception and are implicated in chronic pain. Opioid peptides biosynthesis and opioid receptors density in the nociceptive pathways and their functions change under various conditions associated with neuropathic pain following damage to the spinal cord and injury of peripheral nerves. Identification of a role of opioid systems in neuropathic pain and molecular and cellular mechanisms underlying these processes are of importance to understanding of the opioid action in neuropathic pain that will hopefully facilitate development of therapeutic strategies in which effectiveness of opioids in alleviation neuropathic pain is increased.

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Section: Opioids Systems In Nociception and Neuropathic Pain εNdorphinsmentioning

confidence: 84%

Opioids in Neuropathic Pain

Przewłocki

Przewłocka

2005

CPD

108

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Effects of dorsal root entry zone lesions on CSF and plasma neuropeptides and catecholamines

et al. 1992

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Effects of dorsal root entry zone lesions (DREZLs) on cerebrospinal fluid (CSF) and plasma concentrations of neuropeptides, catecholamines, and cyclic nucleotides were studied in 9 patients with intractable chronic pain. Contents of beta-endorphin-like-material in CSF decreased in all patients 12-17 days following DREZLs during which complete to good pain relief was achieved. Contents of beta-endorphin-like-material in CSF increased again about one month after DREZLs in two and remained unchanged in one of three patients tested, who complained of partial reappearance of pain. Contents of beta-endorphin-like-materials in plasma showed no significant changes after DREZLs. Substance P, noradrenaline, adrenaline, and cyclic nucleotide levels in both CSF and plasma were variable among the subjects and did not change significantly following the operations. Thus, the results suggest that production of beta-endorphin-like-material in the central nervous system is decreased by DREZL, though the increase in its turn-over might not be neglected. The mechanisms of the decrease in contents of beta-endorphin-like-material in CSF after DREZLs were discussed in terms of our current knowledge of pain and pain inhibitory systems.

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Release into ventriculo-cisternal perfusate of β-endorphin- and met-enkephalin-immunoreactivity: effects of electrical stimulation in the arcuate nucleus and periaqueductal gray of the rat

Bach

Yaksh

1995

Brain Research

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Evaluation of beta-endorphin/beta-lipotropin immunoreactivity content in the CSF of patients affected by deafferentation pain syndromes

Cited by 10 publications

References 23 publications

Opioids in Neuropathic Pain

Opioids in Neuropathic Pain

Effects of dorsal root entry zone lesions on CSF and plasma neuropeptides and catecholamines

Release into ventriculo-cisternal perfusate of β-endorphin- and met-enkephalin-immunoreactivity: effects of electrical stimulation in the arcuate nucleus and periaqueductal gray of the rat

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