Evaluation of benzimidazole resistance status in <i>Ascaridia galli</i>

Tarbiat, Behdad; Jansson, Désirée S.; Tydén, Eva; Höglund, Johan

doi:10.1017/s0031182017000531

Cited by 27 publications

(27 citation statements)

References 44 publications

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“…The benzimidazoles, such as fenbendazole and flubendazole, have the same mode of action and are currently the only active substances licensed for use in laying hens and poultry (pheasants and turkeys) in the European Union countries [ 32 ]. In particular, various products marketed in Italy containing flubendazole or fenbendazole (i.e., Panacur AquaSol ® , Intervet International B.V., AN Boxmeer, The Netherlands, Flubenvet ® , Elanco GmbH, Bad Homburg, Germany, Gallifen ® , Huvepharma NV, Sofia, Bulgaria, etc.)…”

Section: Discussionmentioning

confidence: 99%

Use of Flubendazole and Fenbendazole for Treatment of Lung Severe Infection by the Gapeworm Cyathostoma bronchialis (Nematoda: Syngamidae) in Branta hutchinsii, Anser indicus and B. leucopsis Exotic Geese: An Interesting Case

Guerrini

Carminati

Stancampiano

et al. 2021

Veterinary Sciences

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A 6-year-old female goose (Branta hutchinsii) from a group of ornamental exotic geese was found dead due to severe respiratory failure, followed by emission of haemorrhagic sputum and blood clots from the beak and nostrils, and then collapse. At necropsy, the cause of death was attributed to a total of 76 helminth parasites found in the trachea and lungs, then identified as Cyathostoma bronchialis. The flock was initially treated by feed with flubendazole (1200 g/1000 kg/feed) for 7 consecutive days but, at the reappearance of the respiratory symptoms 10 days after, the animals were given fenbendazole by drinking water (300 mg/L) for 7 consecutive days, but at the reappearance of the respiratory symptoms 10 days after, the animals were given fenbendazole via drinking water (300 mg/L) for 7 consecutive days. Despite these treatments, the respiratory symptoms continued to relapse 10–15 days after the end of drug administration. In the literature, there are no data regarding drugs for the treatment of C. bronchialis infestations in geese, and the use of these drugs in exotic birds occurs as “off-label” use. This case study provides information on C. bronchialis life cycle, which is still poorly studied and poorly documented today. In particular, the case provides useful suggestions for evaluating an appropriate protocol for the treatment of C. bronchialis in geese.

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Section: Discussionmentioning

confidence: 99%

Use of Flubendazole and Fenbendazole for Treatment of Lung Severe Infection by the Gapeworm Cyathostoma bronchialis (Nematoda: Syngamidae) in Branta hutchinsii, Anser indicus and B. leucopsis Exotic Geese: An Interesting Case

Guerrini

Carminati

Stancampiano

et al. 2021

Veterinary Sciences

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“…equorum and A . galli ) [12–14], these changes were not found, even in parasite populations that were treated many times a year. This suggests that these SNPs may not correspond to the main mechanism of benzimidazole resistance in these species.…”

Section: Discussionmentioning

confidence: 99%

“…lumbricoides , a mutation at codon 167 was detected at high frequencies in Haiti, Kenya, and Panama in populations that were treated with benzimidazoles [10]; however, mutations at codons 198 or 200 have never been found in this parasite, even though it has already been investigated [7,8,11]. In veterinary ascarids, such as Parascaris equorum and Ascaris galli , these mutations have never been found, even in populations that were constantly treated with benzimidazoles [12–14].…”

Section: Introductionmentioning

confidence: 99%

First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides

et al. 2019

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The main control strategy for Ascaris lumbricoides is mass drug administration (especially with benzimidazoles), which can select strains of parasites resistant to treatment. Mutations in the beta-tubulin isotype-1 gene at codons 167, 198 and 200 have been linked to benzimidazole resistance in several nematodes. The mutation in codon 200 is the most frequent in different species of parasites, as previously observed in Necator americanus and Trichuris trichiura; however, this mutation has never been found in populations of A. lumbricoides. This study aimed to screen for single nucleotide polymorphisms (SNPs) in the beta-tubulin isotype-1 gene at codon 200 in A. lumbricoides. We developed a technique based on an amplification refractory mutation system (ARMS-PCR) for the analysis of 854 single A. lumbricoides eggs collected from 68 human stool samples from seven Brazilian states. We detected the mutation in codon 200 at a frequency of 0.5% (4/854). This is the first report of this mutation in A. lumbricoides. Although the observed frequency is low, its presence indicates that these parasite populations have the potential to develop high levels of resistance in the future. The methodology proposed here provides a powerful tool to screen for the emergence of anthelmintic resistance mutations in parasitic nematode populations.

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“…Nevertheless, in the case of the benzimidazoles, a well-developed understanding of the resistance mechanism has enabled molecular tools to be established for AR detection, which can be used to elucidate patterns of spread of resistance on a broad scale for ruminants [58]. The situation in pigs and poultry, however, is barely known [59].…”

Section: Mechanisms and Processes In Resistancementioning

confidence: 99%

100 Questions in Livestock Helminthology Research

Morgan

Aziz

Blanchard³

et al. 2019

Trends in Parasitology

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An elicitation exercise was conducted to collect and identify pressing questions concerning the study of helminths in livestock, to help guide research priorities. Questions were invited from the research community in an inclusive way. Of 385 questions submitted, 100 were chosen by online vote, with priority given to open questions in important areas that are specific enough to permit investigation within a focused project or programme of research. The final list of questions was divided into ten themes. We present the questions and set them briefly in the context of the current state of knowledge. Although subjective, results provide a snapshot of current concerns and perceived priorities in the field of livestock helminthology, and we hope will stimulate ongoing or new research efforts.

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Evaluation of benzimidazole resistance status in Ascaridia galli

Cited by 27 publications

References 44 publications

Use of Flubendazole and Fenbendazole for Treatment of Lung Severe Infection by the Gapeworm Cyathostoma bronchialis (Nematoda: Syngamidae) in Branta hutchinsii, Anser indicus and B. leucopsis Exotic Geese: An Interesting Case

Use of Flubendazole and Fenbendazole for Treatment of Lung Severe Infection by the Gapeworm Cyathostoma bronchialis (Nematoda: Syngamidae) in Branta hutchinsii, Anser indicus and B. leucopsis Exotic Geese: An Interesting Case

First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides

100 Questions in Livestock Helminthology Research

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