Evaluation of Bayesian Linear Regression Models for Gene Set Prioritization in Complex Diseases
Tahereh Gholipourshahraki,
Zhonghao Bai,
Merina Shrestha
et al.
Abstract:Genome-wide association studies (GWAS) provide valuable insights into the genetic architecture of complex traits, yet interpreting their results remains challenging due to the polygenic nature of most traits. Gene set analysis offers a solution by aggregating genetic variants into biologically relevant pathways, enhancing the detection of coordinated effects across multiple genes. In this study, we present and evaluate a gene set prioritization approach utilizing Bayesian Linear Regression (BLR) models to unco… Show more
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