Evaluation of Bacteriophage Supplementation on Growth Performance, Blood Characteristics, Relative Organ Weight, Breast Muscle Characteristics and Excreta Microbial Shedding in Broilers

Wang, J.P.; Yan, Lei; Lee, J.H.; Kim, In Ho

doi:10.5713/ajas.2012.12544

Cited by 40 publications

(47 citation statements)

References 10 publications

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“…This confirms earlier data from experiments in mice 61 and in broilers in which dietary supplementation with phages increased liver weight 62.…”

Section: Safety Of Phage Therapysupporting

confidence: 91%

“…It should be emphasized that no clinical or laboratory signs of hepatic injury were noted in normal individuals and patients treated with phages [although some of them had some extent of liver dysfuntion (moderate elevation of aminotransferases)], so clinical phage therapy appears to be free of hepatotoxicity [58][59][60]. This confirms earlier data from experiments in mice [61] and in broilers in which dietary supplementation with phages increased liver weight [62].…”

Section: Safety Of Phage Therapysupporting

confidence: 77%

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Therapeutic potential of phages in autoimmune liver diseases

Górski

Jończyk‐Matysiak

Łusiak-Szelachowska

et al. 2018

Clinical and Experimental Immunology

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SummaryAutoimmune liver disease (ALD) poses a difficult medical challenge, as there is a significant number of patients in whom current therapy offers questionable or no benefit, yet its side effects may be serious, including the development of malignancy. Bacterial viruses (phages) have been recognized increasingly as immunomodulators contributing to immune homeostasis and curbing inflammation. Accumulating data suggest that phages may be useful in immunotherapy of ALD. Phages have been shown to down‐regulate the expression and/or production and activity of factors associated with hepatic injury [reactive oxygen species, Toll‐like receptor (TLR)‐4 activation, nuclear factor kappa B (NF‐κB) activation, proinflammatory and procoagulant activities of platelets] and up‐regulate the expression and/or production of factors demonstrated as playing a protective role [interleukin (IL)‐10, IL‐1 receptor antagonist].

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“…This confirms earlier data from experiments in mice 61 and in broilers in which dietary supplementation with phages increased liver weight 62.…”

Section: Safety Of Phage Therapysupporting

confidence: 91%

Section: Safety Of Phage Therapysupporting

confidence: 77%

Therapeutic potential of phages in autoimmune liver diseases

Górski

Jończyk‐Matysiak

Łusiak-Szelachowska

et al. 2018

Clinical and Experimental Immunology

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“…Because of recent limitation of antibiotics addition, new feed additives such as herbs, spices, prebiotics, and probiotics have received increased attention as possible alternatives to antibiotics (Windisch et al 2008;Chu et al 2011;Huang et al 2012;Zhang et al 2012;Liu et al 2013;Wang et al 2013;Zhang & Kim 2013;Zhao et al 2013b;Cho & Kim 2014;Park & Kim 2014;Zhang & Kim 2014).…”

Section: Introductionmentioning

confidence: 99%

β-glucan from mulberry leaves and curcuma can improve growth performance and nutrient digestibility in early weaned pigs

Lee

Kim

Hancock

et al. 2016

Journal of Applied Animal Research

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We investigate the effects of dietary supplementation of β-glucans from mulberry leaves and curcuma on growth performance, nutrient digestibility, blood characteristics, and characteristics of faeces in weaned pigs. A total of 75 crossbred weaned pigs [(Yorkshire × Landrace) × Duroc] with an average body weight (BW) of 8.48 ± 1.65 kg was used in a 5 wk trial. The pigs were sorted into pens with five pigs per pens and five pens per treatments. Treatments were (1) a corn-soybean meal-based control, (2) 0.1% β-glucans from mulberry leaves, and (3) 0.1% β-glucans from curcuma. Pigs fed β-glucans from mulberry leaves and curcuma had higher average daily gain (ADG) and gain/feed intake ratio (G/F) than control. On digestibility, pigs fed β-glucans from mulberry leaves and curcuma had higher on digestibility of dry matter (DM) and energy than corn-soybean meal-based control during 2 weeks. No significant differences were observed on blood characteristics and faecal microflora, score, moisture, and pH among treatments. Difference of mulberry leaves and curcuma was not observed on growth performance, nutrient digestibility, blood characteristics, and characteristics of faeces. In conclusion, dietary supplementation of β-glucan from mulberry leaves and curcuma can improve ADG, G/F, and dry matter and energy of nutrient digestibility in weaned pigs. Therefore, β-glucans can use as antibiotics alternatives, improving the productivity. ARTICLE HISTORY

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“…Thus, much attention has been paid to developing alternatives to antibiotic growth promoters (AGPs) in livestock feed (Yan et al 2012;Zhang et al 2012;Wang et al 2013;Zhang and Kim 2013;Zhao et al 2013;Cho and Kim 2014;Park and Kim 2014;Zhang and Kim 2014). In particular, now that feeding antibiotics is banned, other substances have become increasingly important.…”

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confidence: 99%

Effects of caprylic acid and Yucca schidigera extract on growth performance, relative organ weight, breast meat quality, haematological characteristics and caecal microbial shedding in mixed sex Ross 308 broiler Dickens

Begum¹,

Hossain²,

Kim³

2015

Vet. Med.

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Caprylic acid (CA) and Yucca schidigera (YS) extract have many functional and nutritional properties that may have applications in animal nutrition. These beneficial effects include improvement of growth performance, immunity and anti-microbial activity. This study was conducted to assess the effects of dietary supplementation with CA and YS extract on growth performance, relative organ weight, meat quality, blood characteristics and caecal microbial shedding in broilers. In total, 672 one-day-old Ross 308 (BW of 34.05 ± 0.21 g) mixed-sex broiler chicks were allotted randomly into three dietary treatment groups with 14 replicate pens per treatment and 16 birds per pen. The experiment lasted for five weeks and dietary treatments were as follows: (1) PC, basal diet; (2) PC, basal diet + 44 mg/kg of avilamycin; and (3) CAY100 (basal diet + 100 mg/kg CA + 100 mg/kg YS extract). Chicks fed the CAY100 diet exhibited improved overall body weight gain (BWG) and feed intake (FI), and reduced feed conversion ratio (FCR) compared with those fed the NC diet (P < 0.05). Compared with the NC and PC treatments, mortality was decreased in chicks fed the CAY100 diet during the finisher phase and also overall. Broilers fed the CAY100 diet exhibited increased (P < 0.05) relative organ weight of bursa of Fabricius, compared with the PC diet and demonstrated decreased relative organ weight of the gizzard compared with those fed the NC diet. The relative organ weight of the liver, spleen, breast, and abdominal fat was unaffected by any of the dietary supplements tested. The breast meat redness (a*) was reduced (P < 0.05) in the CAY100 diet compared with the NC and PC diets. White blood cell (WBC) counts were increased in the CAY100 treatment compared with the NC treatment (P < 0.05). Moreover, the CAY100 diet resulted in improved lymphocyte counts compared with the PC and NC diets (P < 0.05). Broilers fed the CAY100 diet exhibited reduced caecal E. coli counts compared with those fed the NC diet (P < 0.05). In conclusion, the CAY extract-supplemented diet improved growth performance, relative weight of bursa of Fabricius and reduced mortality rate, breast muscle a* and caecal E. coli counts in broiler chickens.Keywords: broilers; caprylic acid; E. coli; lymphocyte; breast meat redness; Yucca schidigera List of abbreviations a* = breast meat redness; BW = body weight; BWG = body weight gain; CA = caprylic acid; FCR = feed conversion ratio; FI = feed intake; WBC = white blood cell; YS = Yucca schidigera

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Evaluation of Bacteriophage Supplementation on Growth Performance, Blood Characteristics, Relative Organ Weight, Breast Muscle Characteristics and Excreta Microbial Shedding in Broilers

Cited by 40 publications

References 10 publications

Therapeutic potential of phages in autoimmune liver diseases

Therapeutic potential of phages in autoimmune liver diseases

β-glucan from mulberry leaves and curcuma can improve growth performance and nutrient digestibility in early weaned pigs

Effects of caprylic acid and Yucca schidigera extract on growth performance, relative organ weight, breast meat quality, haematological characteristics and caecal microbial shedding in mixed sex Ross 308 broiler Dickens

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