Evaluation of Bacterial Cellulose Dressing versus Vaseline Gauze in Partial Thickness Burn Wounds and Skin Graft Donor Sites: A Two-Center Randomized Controlled Clinical Study

Abstract

Objective. Bacterial cellulose (BC) dressing, which can maintain a moist environment and prevent the invasion of pathogens, has become a competitive dressing material for burn wound treatment. This study was conducted to evaluate the treatment efficacy of a novel China-made BC dressing for the treatment of second-degree burn wounds and skin graft donor sites. Methods. 212 patients with second-degree burn wounds or skin graft donor sites were enrolled from two research centers. They were randomly assigned to the BC dressing group (study group) or the Vaseline gauze (VG) dressing group (control group). Wound conditions were assessed before and after treatment. Dressings were changed according to the condition of the wound bed. Healing rate and healing time were recorded as primary endpoints to evaluate the efficacy of BC dressing against VG dressing. Erythema, swelling, exudation, bleeding, subeschar purulence, and pain were assessed as secondary endpoints. Results. 207 participants completed the trial and their wounds all healed within 28 days. The average healing times for superficial and deep secondary burn wounds and skin graft donor sites in the BC group were 8.12, 15.77, and 10.55 days, respectively. In the VG group, the average healing times for superficial and deep secondary burn wounds and skin graft donor sites were 9.30, 15.27, and 11.19 days, respectively. The healing time of superficial burn wounds in the BC group was statistically shorter than that in the VG group. There was no difference in the frequency of dressing changing between two groups. The BC dressing showed equal efficacy with the VG dressing at all secondary endpoints. Conclusion. The novel BC dressing could be used for the management of second-degree burn wounds and skin graft donor sites. With a shorter healing time in superficial secondary burn wound than that of the VG dressing, the BC dressing showed noninferiority in the treatment of superficial and deep secondary burn wounds and skin graft donor sites versus the VG dressing. This study is registered with the Chinese Clinical Trial Registry (registry number: ChiCTR1800014377 (http://www.chictr.org.cn)).

Improved Treatment Outcome Following the Use of a Wound Dressings in Cutaneous Leishmaniasis Lesions

“…In experimental L. braziliensis infection, use of an immunomodulator (Tofacitinib) reduced the expression of Granzyme B, protecting mice from severe disease, without altering effector T cell responses [29]. Given our observation that wound dressing with BNC significantly reduced the production of IL-1, we speculate that the effects of BNC may possibly extend beyond its wound healing properties, as shown in diabetic foot ulcers [30], superficial burn injuries and skin graft sites [31], and chronic venous ulcers [18].…”

Outpatient superficial partial‐thickness burn care of an elderly patient successfully treated with Eppikajutsuto

“…According to a past research article, the healing time of a superficial burn wound with Vaseline gauze dressing is 9.30 ± 3.68 days in patients aged 18 to 65 years 6 . Additionally, another article compared clinical outcomes in burn injuries with a median %TBSA ranging from 3.2 to 4.0 among different age categories: 18–64, 65–74, 75–85, and 85+ years.…”

“…According to a past research article, the healing time of a superficial burn wound with Vaseline gauze dressing is 9.30 ± 3.68 days in patients aged 18 to 65 years. 6 Additionally, another article compared clinical outcomes in burn injuries with a median %TBSA ranging from 3.2 to 4.0 among different age categories: 18–64, 65–74, 75–85, and 85+ years. This article states that the median length of stay in the hospital almost tripled ( p < 0.001) from 1.3 days per percent of TBSA in the younger category aged 18–64 years to 3.5 in the oldest one aged 85+.…”

Đánh giá hiệu quả điều trị của băng che phủ vết thương biovb membrane trên vết thương bỏng nông do nhiệt ở trẻ em tại Khoa Chỉnh hình, Bệnh viện Nhi Trung ương

“…Theo Pan (2023) khi so sánh hiệu quả điều trị của NBC với gạc vaselin thấy rằng thời gian khỏi bỏng nông của NBC tốt hơn, ngoài ra còn có thể sử dụng trên vết thương bỏng sâu toàn bộ lớp da và vùng cho da ghép [6].…”