Evaluation of Automated Delivery of Propofol Using a Closed-Loop Anesthesia Delivery System in Patients Undergoing Thoracic Surgery: A Randomized Controlled Study

Accuracy of closed-loop and open-loop propofol delivery systems by bispectral index monitoring in breast surgery patients: a prospective randomized trial

“… 21 Similar outcomes were found in thoracic patients. 22 One possible explanation for the difference was that the closed-loop TCI system regulated the infusion speed more frequently. This closed-loop system allowed monitoring of the BIS value in real time; the system allowed adjustment of the infusion rate every 15 seconds, which was more frequent than the systems used in other studies.…”

Propofol ameliorates renal ischemia/reperfusion injury by enhancing macrophage M2 polarization through PPARγ/STAT3 signaling

“…Propofol (Pro), an intravenous anesthetic, is generally used for the sedation of surgical patients [14,15]. Remarkably, Pro administration has shown to attenuate organ I/R injury and improve surgical outcomes in clinical and preclinical settings [11,[16][17][18].…”

Evaluation of Quality of Recovery With Quality of Recovery-15 Score After Closed-Loop Anesthesia Delivery System-Guided Propofol Versus Desflurane General Anesthesia in Patients Undergoing Transabdominal Robotic Surgery: A Randomized Controlled Study

“…13 However, evidence for propofol TIVA as alternative technique is expanding for its positive clinical effects (decreased incidence of postoperative nausea-and-vomiting, anti-inflammatory effect, antineoplastic action), lower greenhouse impact, and versatility in administering using precision systems (target-controlled infusion, closed-loop automation). 5,14,15 Although low-certainty evidence suggests that propofol TIVA improves QoR-40 on day of surgery in patients undergoing noncardiac surgery; there is limited work to account for full-scope postanesthesia recovery outcomes after major robotic surgery under GA. 16 This randomized study explored the hypothesis that use of automated propofol TIVA would benefit postoperative patient recovery while maintaining a robust GA state intraoperatively and assessed postoperative recovery using a QoR-15 questionnaire in patients undergoing elective robotic surgery under automated propofol-TIVA (administered by closedloop anesthesia delivery system [CLADS]) [17][18][19][20] or desflurane inhalation GA in terms of overall QoR-15 score postoperative day 1 (POD-1) and postoperative day 2 (POD-2) (primary outcome variables), individual QoR-15 item scores (15 nos. ), intraoperative hemodynamics (heart rate, mean blood pressure), anesthesia depth consistency, anesthesia delivery system performance, early recovery from anesthesia (time-to-eye-opening, and time to tracheal extubation), and postoperative adverse events (sedation, PONV, pain, intraoperative awareness recall) (secondary outcome variables).…”

“…This randomized study explored the hypothesis that use of automated propofol TIVA would benefit postoperative patient recovery while maintaining a robust GA state intraoperatively and assessed postoperative recovery using a QoR-15 questionnaire in patients undergoing elective robotic surgery under automated propofol-TIVA (administered by closed-loop anesthesia delivery system [CLADS]) 17–20 or desflurane inhalation GA in terms of overall QoR-15 score postoperative day 1 (POD-1) and postoperative day 2 (POD-2) (primary outcome variables), individual QoR-15 item scores (15 nos. ), intraoperative hemodynamics (heart rate, mean blood pressure), anesthesia depth consistency, anesthesia delivery system performance, early recovery from anesthesia (time-to-eye-opening, and time to tracheal extubation), and postoperative adverse events (sedation, PONV, pain, intraoperative awareness recall) (secondary outcome variables).…”