Evaluation of Autogenous Engineered Septal Cartilage Grafts in Rabbits: A Minimally Invasive Preclinical Model

Abstract

Oral PresentationsP37 drawings using this method. The authors suggest a recording system using a mobile device and have found it useful in storing and transmitting the drawings.Methods: Based on iPad 4.0, the rhinoplasty record application program (Rhinograph) was developed. The SQLite was used as an internal database, and the program was developed using XCode 4. The authors kept the operation records of 10 patients who had undergone rhinoplasty and confirmed the usefulness and convenience of this system. Results:The program was divided into 6 parts: 1) the operation sheet (operation registration, surgical details, and notations), 2) looking up, modifying, and converting the system to PDF/ JPG files with email transmissions, 3) the template developing system with frequently used techniques, 4) the database backup and conversion to Excel files, 5) registering user emails and signatures, and 6) the description of the applications. The program resulted in equal convenience and accuracy as hand-drawing among the 10 patients. In addition, the mobile device was easily carried in the operating room and outpatient clinics.Conclusions: The rhinoplasty recording system using a mobile device was found to be as effective as the traditional way of recording and helped remove the constraints of place. In addition, it was shown to be convenient to store and analyze the data.

Tissue engineering applications in otolaryngology—The state of translation

“…The lack of autologous analogues for nasal reconstruction has led to the pursuit of graft candidates using allogeneic and synthetic materials. The efficacy of these materials is well described, as are their associated complications: synthetic materials can extrude, become infected, and cause a foreign body reaction 8,9 . Likewise, allogeneic grafts are associated with immune rejection and disease transmission 8,9 .…”

“…The efficacy of these materials is well described, as are their associated complications: synthetic materials can extrude, become infected, and cause a foreign body reaction 8,9 . Likewise, allogeneic grafts are associated with immune rejection and disease transmission 8,9 . Tissue engineered cartilaginous constructs can provide tissue designed to fit the specific geometric and functional requirements of a given defect while also avoiding donor site morbidity.…”

“…Twenty‐six articles were found to involve TE applications for nasal reconstruction since 2014 (Figure 3). While the total study number is relatively small, these studies present a suitable evaluation of histologic characteristics, mechanical properties, regenerative potential, and the ability to create a 3D construct using primarily in vitro and small in vivo models 8,10‐19 . There has been an absence of testing in large animal models, however, there have been multiple attempts (four studies) to replace nasal cartilage subunits in humans 9,20‐22 …”

“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate nasal tissue engineering 8‐24,98‐106 …”

Computational technology for nasal cartilage-related clinical research and application

“…For the first nasal cartilage target, with the development of tissue engineering, four elements have gradually been developed: cells, scaffolds, bioactive factors and physical features. 145 Different cells, 146 – 148 scaffolds from different materials, 149 – 153 and different bioactive factors 154 , 155 have been applied to the tissue engineering of nasal cartilage and have achieved good results, but tissue engineering related to physical factors is more common in other types of cartilage. 156 , 157 Nevertheless, the 3D bioprinting of nasal cartilage remains in the experimental stage because it is limited by the clinical application of related bioactive factors.…”