Evaluation Of Attenuation Reduction Of A Dedicated Carotid Pet/Mri Coil For Carotid Plaque Imaging

Aizaz, S.; Moonen, Rik P. M.; Wierts, Roel; Pol, Jochem A. J. van der; Zwart, Hans H.J.; Werf, A.J. van der; Wildberger, JE; Bucerius, Jan; Kooi, M. Eline

doi:10.1016/j.atherosclerosis.2019.06.145

Cited by 2 publications

(2 citation statements)

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“…2) Extended MRbased MOCO (eMR-MOCO), where both the iNav respiratory signal (as described earlier, but only available during ~ 9 minutes of CMRA imaging) and the respiratory belt signal (available entire PET acquisition) are used. [20] The time window for which both the iNav respiratory signal and respiratory belt signal was collected, was used to ensure that the binning of PET data on the iNav signal closely matches the binning on the respiratory belt signal by adjusting binning thresholds. These thresholds are then extended for respiratory motion correction of the complete duration of the PET scan.…”

Section: Image Reconstructionmentioning

confidence: 99%

Molecular imaging of coronary plaque vulnerability using 18F- fluorocholine PET-MRI in patients with coronary artery disease: validation with optical coherence tomography

Pol,

Rahel,

Cauteren

et al. 2024

Preprint

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Purpose 18F-fluorocholine is a positron emission tomography (PET) tracer earlier found to be a marker of macrophage content in carotid plaques. We aimed to assess the feasibility of 18F-choline PET-MRI to non-invasively localize vulnerable coronary plaques, using optical coherence tomography (OCT) as reference standard. Methods Patients with recent myocardial infarction who were scheduled for a secondary angiography of a non-culprit vessel, underwent 18F-fluorocholine coronary PET-MRI. Subsequently, OCT was performed during the secondary angiography. Maximum target-to-background (TBRmax) values of 18F-fluorocholine uptake were determined in two vessel sections that contained either vulnerable or stable plaques as defined by OCT. The OCT-based definition of a vulnerable plaque was a fibrous cap thickness <70µm. To enhance the detectability of coronary plaques using PET, three different motion-correction strategies were used: multigate respiratory gating motion correction (MRG-MOCO), extended MR-based motion correction (eMR-MOCO), and extended MR-based motion correction with ECG gating (eMR-MOCO-ECG). Results Fifteen patients were included in this study, of which eleven entered final analyses. Data of the other four subjects could only be partially analysed. TBRmax values were as follows for three different reconstructions in vulnerable versus stable plaques: MRG-MOCO: mean TBRmax 1.45 vs 1.35, p=0.52; eMR-MOCO mean TBRmax 1.47 vs 1.27, p= 0.26, eMR-MOCO-ECG: mean TBRmax 1.49 vs 1.26, p= 0.21. Conclusion 18F-fluorocholine uptake in vulnerable atherosclerotic plaques in coronary arteries was not significantly different from uptake in stable plaques even though advanced motion-correction methods were applied. That may be caused by multiple factors, such as small coronary plaque size and remaining cardiac motion.

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Section: Image Reconstructionmentioning

confidence: 99%

Molecular imaging of coronary plaque vulnerability using 18F- fluorocholine PET-MRI in patients with coronary artery disease: validation with optical coherence tomography

Pol,

Rahel,

Cauteren

et al. 2024

Preprint

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“…One solution is to use markers to locate the position and shape of the coil in MR images and subsequently use nonrigid transformations to transform a CT based attenuation map of the coil (61). Another solution is to use dedicated PET/MRI coils which reduce photon attenuation for the ROI by making design changes and less attenuating materials (62,63).…”

Section: Attenuation Correction For Pet In Pet/mrimentioning

confidence: 99%

PET/MRI of atherosclerosis

Aizaz¹,

Moonen²,

Pol³

et al. 2020

Cardiovasc Diagn Ther

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Myocardial infarction and stroke are the most prevalent global causes of death. Each year 15 million people worldwide die due to myocardial infarction or stroke. Rupture of a vulnerable atherosclerotic plaque is the main underlying cause of stroke and myocardial infarction. Key features of a vulnerable plaque are inflammation, a large lipid-rich necrotic core (LRNC) with a thin or ruptured overlying fibrous cap, and intraplaque hemorrhage (IPH). Noninvasive imaging of these features could have a role in risk stratification of myocardial infarction and stroke and can potentially be utilized for treatment guidance and monitoring. The recent development of hybrid PET/MRI combining the superior soft tissue contrast of MRI with the opportunity to visualize specific plaque features using various radioactive tracers, paves the way for comprehensive plaque imaging. In this review, the use of hybrid PET/MRI for atherosclerotic plaque imaging in carotid and coronary arteries is discussed. The pros and cons of different hybrid PET/MRI systems are reviewed. The challenges in the development of PET/MRI and potential solutions are described. An overview of PET and MRI acquisition techniques for imaging of atherosclerosis including motion correction is provided, followed by a summary of vessel wall imaging PET/MRI studies in patients with carotid and coronary artery disease. Finally, the future of imaging of atherosclerosis with PET/ MRI is discussed.

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Evaluation Of Attenuation Reduction Of A Dedicated Carotid Pet/Mri Coil For Carotid Plaque Imaging

Cited by 2 publications

References 0 publications

Molecular imaging of coronary plaque vulnerability using 18F- fluorocholine PET-MRI in patients with coronary artery disease: validation with optical coherence tomography

Molecular imaging of coronary plaque vulnerability using 18F- fluorocholine PET-MRI in patients with coronary artery disease: validation with optical coherence tomography

PET/MRI of atherosclerosis

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