Evaluation of Atrial Fibrillation and Premature Ventricular Contractions due to Magnesium Sulfate Administration after Open Heart Surgery

Comparing the Effect of Perioperative Amiodarone and Magnesium Sulphate Combination with Magnesium Sulphate for Prevention of Cardiac Dysrhythmias in Open Heart Surgeries: A Quasi-Experimental Study

“…Although the precise etiology of dysrhythmias following cardiac surgery is unknown but preoperative variables such as advanced age, enlarged left atrium, left ventricular dysfunction, hypertension, chronic kidney disease, COPD, obesity, multiple vessels disease, previous history of dysrhythmias, recent myocardial infarction, hyperthyroidism, electrolyte imbalance including imbalanced potassium and E Ef ff fe ec ct t o of f A Am mi io od da ar ro on ne e o on n C Ca ar rd di ia ac c A Ar rr rh hy yt th hm mi ia as s Pak Armed Forces Med J 2023; 73(Suppl-3): S565 deficiency of magnesium are the main causes of dysrhythmias. 12 Intraoperative and postoperative factors like cardiopulmonary bypass time, cross-clamp time, atrial injury, inadequate cardiac protection, exogenous and endogenous catecholamine, electrolytes imbalance, beta-blockers withdrawal, reopening due to bleed, poor grafts or targets, post-operative pain, hypoxemia and sepsis also introduced dysrhythmias. In our study, remarkable decrease in the incidence of arrhythmias was due to the combined usage of magnesium sulphate and amiodarone 22(16.7%) vs 49(37.4%) p<0.001, whereas Sharma S. et al reported that they used either magnesium or amiodarone as prophylaxis.…”

“…14,15 Heidaranlu et al showed that magnesium sulphate administration appeared to be effective in avoiding new occurrences of atrial fibrillation and ventricular ectopic prior to, during, and after open heart surgery. 12 In patients with rheumatic valvular heart disease, Rehman at el. investigated the effects of intraoperative loading doses of amiodarone for prophylaxis against atrial fibrillation.…”