Evaluation of Atopic Dermatitis and Cutaneous Infectious Disorders Using Sequential Pattern Mining: A Nationwide Population-Based Cohort Study

Abstract

According to previous studies, the increased risk of cutaneous infectious disorders in patients with atopic dermatitis (AD) is related to impaired epidermal function, abnormal systemic immune function, and lower antimicrobial peptides. In this study, we analyzed the association between AD and cutaneous infectious disorders in the real world using sequential pattern mining (SPM). We analyzed National Health Insurance data from 2010–2013 using SPM to identify comorbid cutaneous infectious diseases and the onset durations of comorbidities. Patients with AD were at greater risk for molluscum contagiosum (adjusted odds ratio (aOR), 5.273), impetigo (aOR, 2.852), chickenpox (aOR, 2.251), otitis media (aOR, 1.748), eczema herpeticum (aOR, 1.292), and viral warts (aOR, 1.105). In SPM analysis, comorbidity of 1.06% shown in molluscum contagiosum was the highest value, and the duration of 77.42 days documented for molluscum contagiosum was the shortest onset duration among all the association rules. This study suggests that AD is associated with an increased risk of cutaneous infectious disorders. In particular, care should be taken regarding its high relevance with impetigo, molluscum contagiosum, and otitis media, which may help in preventing AD from worsening through appropriately preventing and managing the condition.

Guía de dermatitis atópica para México (GUIDAMEX): lineamientos usando metodología ADAPTE

“…**Punto de buena práctica: la DA se asocia con un riesgo mayor de trastornos infecciosos cutáneos. Un estudio reciente de cohorte encontró relevancia alta por frecuencia elevada de comorbilidades infecciosas para impétigo, molusco contagioso y otitis media, su identificación puede ayudar a prevenir el empeoramiento de la DA mediante la prevención y el manejo adecuados de la afección 156 . Las exacerbaciones agudas de los síntomas oculares y el deterioro visual justifican la referencia urgente a oftalmología 157 .…”

Applying Sequential Pattern Mining to Investigate the Temporal Relationships between Commonly Occurring Internal Medicine Diseases and Intervals for the Risk of Concurrent Disease in Canine Patients

“…Beyond retail, SPM was applied as a methodology to investigate relationships among medical events, and develop predictive models for extensive healthcare data in human medicine [1,8]. SPM-derived studies applied to medicine have demonstrated promising outcomes, including disease susceptibility prediction [9,10], improved understanding of disease progression patterns [11,12], identification of revisit patterns [13,14], enhanced pharmacovigilance for medication safety [15,16], and the exploration of relationships between medical conditions [17,18]. Despite several limitations, including variations in data quality, privacy concerns, the complexity of developing predictive models, and ethical considerations regarding data usage and transparency, medical research employing SPM has been actively reported to date [19,20].…”

Dupilumab: Two sides of a side‐effect

“…The prevalence of cutaneous warts in primary school children is high (up to 33%) 2 . Children suffering from AD have an increased risk for cutaneous warts (age/sex‐adjusted odds ratio [aOR] = 1.10, 95% confidence interval [CI]: 1.05–1.17), and an even higher risk for developing molluscum contagiosum (aOR = 5.27, CI: 5.13–5.42) 3 . Although most warts eventually resolve spontaneously, 2 many are recalcitrant owing to intricate immune escape mechanisms inherent both to human papillomavirus 4 as well as molluscum contagiosum virus 5 .…”