Evaluation of arterial obstructive leg and foot disease by three-phase bone scintigraphy

Masaoka, Satoru

doi:10.1007/bf02987847

Cited by 12 publications

(5 citation statements)

References 15 publications

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“…This can be explained by the fact that DA develops on the background of diabetic angiopathy. It is important to note that to date, many researchers have found a link between impaired bone metabolism and mediacalcinosis of the arteries, which occurs in patients with DM much more often than in the general population [14,15].…”

Section: Discussionmentioning

confidence: 99%

Radіonuclіde dіagnostіcs of joіnt іnjury іn patіents wіth dіabetes

Orlenko

Ivaskiva

Zubkova

2020

ScienceRise: Medical Science

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Section: Discussionmentioning

confidence: 99%

Radіonuclіde dіagnostіcs of joіnt іnjury іn patіents wіth dіabetes

Orlenko

Ivaskiva

Zubkova

2020

ScienceRise: Medical Science

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“…Impaired circulation, hydration level, renal function, and age also influence uptake (1,2). A bone scan is a useful adjunct to choose appropriate amputation level by aiding in distinguishing viable from nonviable tissue (3).…”

Section: Discussionmentioning

confidence: 99%

Looking Beyond the Indication: Bone Scan for Trauma Providing Unsuspected Initial Diagnosis of Acute Critical Lower Limb Arterial Compromise

Manzil

Almodovar

Bhambhvani

2017

J. Nucl. Med. Technol.

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“…Accurate and objective assessment of necrotic tissue for early detection is valuable in the management of such patients and can have a significant impact on improving morbidity and mortality [1]. Nevertheless, patients with arterial obstructive lower extremity disease are also at high intraoperative risks due to coronary or cerebral artery obstruction and, therefore, any surgery performed should be confined to a single occasion in order to prevent further intervention [2].…”

Section: Introductionmentioning

confidence: 99%

Ischemic Muscle Necrosis of Lower Extremities in Peripheral Arterial Disease: The Impact of 99mTc-MDP Scintigraphy on Patient Management

et al. 2019

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Background and objectives: The objective of this study was to assess the value of a whole-body bone scintigraphy using 99m technetium labelled-methyl diphosphonate (99mTc-MDP) for the diagnosis and the assessment of grades of muscle damage after prolonged acute or chronic obstruction of the main arteries in lower extremities. Material and Methods: Fifty consecutive patients were selected for the study. The patients’ condition had not improved after primary peripheral arterial reconstruction operation or limb amputation and after conservative treatment. The clinical suspicion was of arterial obstruction and muscle necrosis. All the patients underwent whole-body scintigraphy with 99mTc-MDP. Muscle necrosis was identified as an increased soft tissue uptake of 99mTc-MDP. Results: Forty-five patients had gross muscle necrosis detected on whole-body scintigraphy with 99mTc-MDP and were histologically confirmed after repeated surgery (necrectomy or amputation) or by muscle biopsy, if only fasciotomy was performed. The location and extent of muscle injury were assessed preoperatively and the findings were confirmed in all 45 patients. Twelve patients with clinically suspected minor muscle damage, which was confirmed as relatively minor muscle necrosis on 99mTc-MDP scintigraphy, were treated conservatively. The clinical outcome of all 50 patients was favorable. The 99mTc-MDP scintigraphy, in detection of muscular necrosis, demonstrated sensitivity, specificity, and accuracy of 97.3% (95% confidence interval (CI) 85.4 to 99.3%), 30.77% (95% confidence interval (CI) 9.09 to 61.43%), and 80% (95% confidence interval (CI) 66.28 to 89.97%), respectively. Conclusion: The 99mTc-MDP scintigraphy is a valuable tool in the detection of muscular necrosis. It is able to define location, extent, and grade of involvement. Therefore, it has a clinical impact in patient management, allowing clinicians to select adequate treatment policy and specify the scope of necrectomy.

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Evaluation of arterial obstructive leg and foot disease by three-phase bone scintigraphy

Abstract: The results of this study suggest that TPBS is an extremely useful tool in the evaluation of physiological dysfunction and the likely amputation level in patients with arterial obstructive leg and foot disease.

Cited by 12 publications

References 15 publications

Radіonuclіde dіagnostіcs of joіnt іnjury іn patіents wіth dіabetes

Radіonuclіde dіagnostіcs of joіnt іnjury іn patіents wіth dіabetes

Looking Beyond the Indication: Bone Scan for Trauma Providing Unsuspected Initial Diagnosis of Acute Critical Lower Limb Arterial Compromise

Ischemic Muscle Necrosis of Lower Extremities in Peripheral Arterial Disease: The Impact of 99mTc-MDP Scintigraphy on Patient Management

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