Evaluation of aqueductal cerebrospinal fluid flow dynamics with phase-contrast cine magnetic resonance imaging in normal pediatric cases

Öztürk, Mehmet; Sigirci, Ahmet; Ünlü, Serkan

doi:10.1016/j.clinimag.2016.09.005

Cited by 13 publications

(18 citation statements)

References 25 publications

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“…The acquisitions are synchronized with the cardiac cycle generating images with velocity information providing the ability to calculate stroke volume, mean velocity, and peak flow in systole and diastole. The results can be represented via graphical plot [10–15]. Table 3 shows the normal values of CSF flow indices measured across the aqueduct of Sylvius.…”

Section: Mri Protocolmentioning

confidence: 99%

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The value of CSF flow studies in the management of CSF disorders in children: a pictorial review

2019

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CSF flow disorders are frequently encountered in children. The advent of MR technology with the emergence of new pulse sequences allowed better understanding of CSF flow dynamics. In this pictorial review, we aim to conduct a comprehensive review of the MR protocol used to study CSF flow disorders and to discuss the utility of each pulse sequence in the adopted protocol. We will focus on the key anatomical structures that should be examined to differentiate hydrocephalus form ventricular dilatation ex-vacuo. The MR features of obstructive and communicating hydrocephalus will be discussed, in addition to the manifestations of CSF disorders associated with posterior fossa malformations (Dandy-Walker malformation, Chiari, and Blake’s pouch cyst). Moreover, the value of MRI in the assessment of patients following interventional procedures (ventriculoperitoneal shunt and third ventriculostomy) will be addressed.Electronic supplementary materialThe online version of this article (10.1186/s13244-019-0686-x) contains supplementary material, which is available to authorized users.

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Section: Mri Protocolmentioning

confidence: 99%

“…The results can be represented via graphical plot [10–15]. Table 3 shows the normal values of CSF flow indices measured across the aqueduct of Sylvius.…”

Section: Mri Protocolmentioning

confidence: 99%

The value of CSF flow studies in the management of CSF disorders in children: a pictorial review

2019

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“…In conjunction with the publication by Unal et al, we came across no difference between boys and girls with respect to forward flow volume, reverse flow volume, and net volume [17]. In a study with PC-MRI in healthy children, the cranial, caudal, and net volume values were determined to be 0.018 ± 0.016, 0.014 ± 0.22, and 0.010 ± 0.016 ml, respectively, in boys and 0.011 ± 0.001, 0.011 ± 0.018, and 0.004 ± 0.003 ml, respectively, in girls [16]. The cranial and net volume values were found to be higher in boys.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the popularization of high-resolution imaging modalities, errors may still occur, especially for velocity-related parameters. These errors may insource from the nonlinear gradients, eddy flows, partial volume effects, and malpositioning of region of interest (ROI) [2,15,16]. PC-MRI has several limitations.…”

Section: Discussionmentioning

confidence: 99%

Is cerebral spinal fluid flow associated with body mass index and head circumference in healthy children? A phase contrast magnetic resonance imaging study

Demirtaş

Sigirci

Öztürk

et al. 2020

Egypt J Radiol Nucl Med

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Background: The aim of this study was to investigate the relationship between age, gender, body mass index (BMI), and head circumference (HC) and cerebral spinal fluid (CSF) flow dynamics in the pediatric population. The prospective study included a total of 137 participants, 75 boys and 62 girls, ranging in age from 2 to 204 months. Quantitative evaluation of CSF flow was made by using phase contrast magnetic resonance imaging (PC-MRI) in the axial plane at the level of the aqueductus cerebri. Flow dynamics were recorded as peak and mean velocity (cm/s); cranial, caudal, and net volume (ml); and aqueductus cerebri area (mm 2). Correlation between baseline descriptive parameters, including age, gender, BMI, and HC, and the aforementioned CSF flow dynamics were investigated. Results: The net volume was significantly lower in girls (p = 0.002). There was no association between age and aqueduct area, mean velocity, and cranial volume. The peak velocity was remarkably higher in children (p = 0.03), whereas cranial and net volume were found to be lower in infants (p = 0.04 and p = 0.03, respectively). Notably, cases with HC below normal values had lower cranial, caudal, and net volume and aqueductus cerebri area (p = 0.01, p = 0.03, p = 0.03, and p = 0.04, respectively). There was no association between BMI and indicators of CSF flow dynamics in PC-MRI. Conclusion: BMI and HC may be associated with CSF flow dynamics in children. A smaller HC is accompanied by a lower forward flow volume, reverse flow volume, net volume, and aqueductal diameter. These points should be remembered during the design of further trials on determinants of CSF flow in children.

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“…There have been few studies evaluating CSF dynamic parameters and their association with age and sex in normal pediatric subjects. Öztürk et al ( 20 ) studied 83 healthy pediatric subjects and found a peak velocity of 5.77 ± 3.18 cm/s and a mean velocity of 0.83 ± 0.73 cm/s. They also found significant differences in peak velocities between adolescents and children, as well as between males and females, although they found no significant differences in mean velocities.…”

Section: Discussionmentioning

confidence: 99%

Cine phase-contrast magnetic resonance imaging evaluation of cerebrospinal fluid flow dynamics in healthy pediatric subjects

2022

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Objective: To evaluate cerebrospinal fluid dynamics, using cine phase-contrast magnetic resonance imaging (cine-PC MRI), in healthy pediatric subjects, determining the normal flow values in this population, as well as identifying differences related to age, sex, and body surface area. Materials and Methods: This was a descriptive cross-sectional study involving 32 healthy children and adolescents, in whom the flow of cerebrospinal fluid through the cerebral aqueduct was evaluated quantitatively with cine-PC MRI. We used specialized software to analyze the images obtained with cine-PC MRI, drawing a region of interest on the aqueduct. A flow-time curve was obtained, as were automated measurements of the various parameters. Results: The following normal (mean) values were obtained: net flow, 1.10 ± 0.99 mL/m; stroke volume, 12.2 ± 10.1 μL/cycle; mean velocity, 0.72 ± 1.00 cm/s; peak systolic velocity, 5.28 ± 2.30 cm/s; peak diastolic velocity, 4.51 ± 1.77 cm/s. These values were not affected by age or sex. In addition, body surface area was not found to correlate significantly with mean velocity or stroke volume. Conclusion: In children and adolescents, the basic cerebrospinal fluid flow parameters, as determined by cine-PC MRI, appear to be independent of age and sex.

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Evaluation of aqueductal cerebrospinal fluid flow dynamics with phase-contrast cine magnetic resonance imaging in normal pediatric cases

Cited by 13 publications

References 25 publications

The value of CSF flow studies in the management of CSF disorders in children: a pictorial review

The value of CSF flow studies in the management of CSF disorders in children: a pictorial review

Is cerebral spinal fluid flow associated with body mass index and head circumference in healthy children? A phase contrast magnetic resonance imaging study

Cine phase-contrast magnetic resonance imaging evaluation of cerebrospinal fluid flow dynamics in healthy pediatric subjects

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