Evaluation of apoptosis in human breast cancer cell (MDA-MB-231) induced by ZnO nanoparticles synthesized using Piper betle leaf extract as bio-fuel

Nagarajaiah, Shobha; Nanda, N.; Manjappa, Praveen; Nagabhushana, Bhangi Mutta; Gadewar, Manoj; Rao, Srilatha; Krishna, Prashanth Gopala

doi:10.1007/s00339-023-06731-w

Cited by 5 publications

(2 citation statements)

References 52 publications

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“…[15][16][17] Studies have shown that ZnO NPs have a direct effect on cancer cells, pathogens, and the host's immune system by causing the activation of immune cells. [18,19] Recently, the FDA (Food and Drug Administration) recognised zinc oxide as a material that is generally recognised as safe (GRAS). [20] Zinc sulphate heptahydrate, ZnSO 4 .7H 2 O, is an inorganic non-linear optical crystal.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, Characterization and In Vitro Cell Cytotoxicity of ZnO Nanoparticles on MDA‐MB 231 Breast Cancer Cell Line

Kumar Janakiraman,

Yin Wong,

Cheng

et al. 2023

ChemistrySelect

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The intention of this study was to prepare zinc oxide nanoparticles (ZnO‐NPs) via bottom‐up approach and evaluate their physiochemical, antimicrobial and anticancer properties. ZnO‐NPs were first prepared by the direct precipitation method with zinc sulphate heptahydrate, followed by characterization tests using sophisticated analytical and imaging instruments. Upon characterization, ZnO‐NPs were studied for their antimicrobial activities against Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa as well as their anticancer activity against breast cancer cell line (MDA‐MB 231). The ZnO‐NPs possessed a mean particle diameter of 225.2 nm and a zeta potential of −15.8 mV. A sharp absorption peak of ZnO was recorded at 354 nm via UV‐Visible spectroscopy. Hexagonal wurtzite shape of ZnO‐NPs has been observed and confirmed by Scanning Electron Microscopy (SEM) and X‐Ray diffraction (XRD). ZnO‐NPs exhibited excellent antimicrobial activity against the Gram‐positive bacteria, Staphylococcus aureus. In an in vitro cell cytotoxicity study, ZnO‐NPs showed a dose‐dependent relationship against MDA‐MB 231 breast cancer cells. It was observed that as the concentration of ZnO‐NPs increased (0.25 μg to 35 μg), there was a sharp reduction in the proliferation rate of the cancer cell line. Overall, our study reported successful synthesis of ZnO‐NPs, which can be efficient antibacterial and anticancer agents.

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Section: Introductionmentioning

confidence: 99%

Fabrication, Characterization and In Vitro Cell Cytotoxicity of ZnO Nanoparticles on MDA‐MB 231 Breast Cancer Cell Line

Kumar Janakiraman,

Yin Wong,

Cheng

et al. 2023

ChemistrySelect

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“…These features provide additional reactive sites and excellent light absorption properties, thus improving photocatalytic efficiency. Several conventional techniques for fabricating nanoscale photocatalysts include hydrothermal, solvothermal, sol-gel, and precipitation methods have been investigated [ 5 , 6 , 7 ]. These approaches enable meticulous regulation of the photocatalyst’s particle size and morphology.…”

Section: Introductionmentioning

confidence: 99%

Sustainable Development of ZnO Nanostructure Doping with Water Hyacinth-Derived Activated Carbon for Visible-Light Photocatalysis

Krobthong,

Rungsawang,

Khaodara

et al. 2024

Toxics

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Water hyacinth (Wh) is an aquatic weed considered a nuisance in agricultural and fishing activities. Therefore, this study proposed repurposing this plant into activated carbon (AC). First, the ZnO-AC was precipitated and applied as a photocatalyst for degrading methylene blue. The preliminary photocatalytic test under UV irradiation identified the optimum ZnO-AC photocatalyst to degrade methylene blue (MB). The ZnO-AC photocatalyst recorded the highest degradation rate constant of 11.49 × 10−3 min−1, which was almost two-fold higher than that of ZnO (5.55 × 10−3 min−1). Furthermore, photocatalytic degradation of MB and carbaryl under sunlight irradiation by ZnO-AC demonstrated degradation rate constants of 74.46 × 10−3 min−1 and 8.43 × 10−3 min−1, respectively. To investigate the properties of ZnO-AC, several techniques were performed. ZnO-AC and ZnO exhibited similar results in morphology, crystalline structure, and Raman characteristics. However, ZnO-AC presented smaller pore diameters than those of ZnO, which enlarged pore surface area, and the presence of carbon-related groups implied the presence of AC on ZnO-AC surfaces. This can be attributed to the presence of AC on the ZnO surface, increasing the capture of surrounding toxic molecules and elevating the reaction density. This mechanism is attributed to promoting the degradation of toxic molecules. Therefore, using Wh as a carbon source for the transformation of AC can alternatively solve the problems of aquatic weed management and carbon storage strategies, and the application of AC in ZnO-AC photocatalysts can enhance photocatalysis.

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Zinc Oxide Nanostructures: Illuminating the Potential in Biomedical Applications: a Brief Overview

Prashanth,

Dileep,

Gadewar

et al. 2024

BioNanoSci.

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Evaluation of apoptosis in human breast cancer cell (MDA-MB-231) induced by ZnO nanoparticles synthesized using Piper betle leaf extract as bio-fuel

Cited by 5 publications

References 52 publications

Fabrication, Characterization and In Vitro Cell Cytotoxicity of ZnO Nanoparticles on MDA‐MB 231 Breast Cancer Cell Line

Fabrication, Characterization and In Vitro Cell Cytotoxicity of ZnO Nanoparticles on MDA‐MB 231 Breast Cancer Cell Line

Sustainable Development of ZnO Nanostructure Doping with Water Hyacinth-Derived Activated Carbon for Visible-Light Photocatalysis

Zinc Oxide Nanostructures: Illuminating the Potential in Biomedical Applications: a Brief Overview

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