Evaluation of antral mast cells in nonulcer dyspepsia

Matter, Stephen E.; Bhatia, Paramjit; Miner, Philip B.

doi:10.1007/bf01536741

Cited by 37 publications

(20 citation statements)

References 13 publications

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“…In the current study, we defined abnormal antral mast cell density as [15 cells/hpf. While no generally accepted standard exists for defining increased mast cell density, we chose[15 cells/ hpf because this corresponded to the 95th percentile value in a previous study of 225 adult FD patients [29]. We defined an abnormal eosinophil density as [10/hpf [30,31].…”

Section: Inflammationmentioning

confidence: 99%

Antral Inflammatory Cells, Gastric Emptying, and Electrogastrography in Pediatric Functional Dyspepsia

et al. 2008

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The aims of the current study were to determine the activation states of antral eosinophils and mast cells and to evaluate the interactions of antral inflammatory cells with gastric emptying and electrogastrography (EGG) in 30 pediatric patients with functional dyspepsia. Eosinophil degranulation was moderate in 42% and extensive in 54% of patients. Mast cell degranulation was > 50% in 81% of patients. Elevated mast cell density was associated with slower one hour gastric emptying and increased preprandial dysrhythmia. Mast cell density correlated with the preprandial percentage tachygastria. CD3+ cell density correlated with the preprandial percentage tachygastria also, but only in patients with increased eosinophil density. In conclusion, antral eosinophils and mast cells are significantly activated in pediatric functional dyspepsia. Mast cell density is associated with delayed gastric emptying and preprandial dysrhythmia, suggesting that there may be an interaction between antral inflammation and gastric electromechanical dysfunction in the pathophysiology of pediatric functional dyspepsia.

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Section: Inflammationmentioning

confidence: 99%

Antral Inflammatory Cells, Gastric Emptying, and Electrogastrography in Pediatric Functional Dyspepsia

et al. 2008

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“…Anecdotal reports suggest that histamine receptor antagonists [60] and the well-known anti-histaminic effects of tricyclic antidepressants [61,62] may participate in the symptomatic improvement in functional gut disorders. In a recent uncontrolled study, 70% of 47 patients with chronic intractable diarrhoea, almost half of whom had IBS-D, had increased mast cells.…”

Section: Other Compounds With Proven or Potential Anti-inflammatory Pmentioning

confidence: 99%

Aminosalicylates and Other Anti-Inflammatory Compounds for Irritable Bowel Syndrome

Barbara

Stanghellini

Cremon

et al. 2009

Dig Dis

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Growing evidence suggests that gastrointestinal immune activation may affect intestinal function and sensory perception, which contribute to symptom generation in patients with irritable bowel syndrome (IBS). The identification of higher counts of immunocytes (e.g. T cells and mast cells), mucosal and systemic immune activation, and increased mucosal permeability in patients with IBS has stimulated interest in the potential development of therapeutic approaches aimed at targeting the immune system and inflammation. Although an initial attempt in a pilot trial with steroids in patients with post-infective IBS failed, there has been renewed interest for mast cell stabilizers and the therapeutic potential of aminosalicylates. A recent randomized, double-blind, placebo-controlled pilot trial assessed the effect of mesalazine on intestinal immune cells and symptom perception in patients with IBS. Mesalazine markedly reduced mucosal immune cells and mast cells in particular, compared to placebo. In addition, mesalazine significantly improved general well-being. Mesalazine may enhance epithelial barrier function, and preliminary data suggest that it may alter faecal bacterial profiles in IBS patients. Nevertheless, the exact mechanism through which this drug affects immune activation in the intestine of patients with IBS remains unknown. There is a need for further studies to prove the efficacy of mesalazine for IBS. Further studies aimed at assessing the role of aminosalicylates and other approaches with potential anti-inflammatory activity, including probiotics, non-absorbable antibiotics, histamine receptor antagonists and protease inhibitors on IBS symptoms or pathophysiology are now warranted.

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“…Mast cell degranulation has also been detected by electron microscopy in the gastric mucosa of patients with peptic ulcer [17]. Moreover, therapy with histamine H 1 antagonists reduces the symptoms of patients with non-ulcer dyspepsia with increased mast cell numbers in their gastric biopsy specimens [29]. It has been suggested that mast cell activation by H. pylori factors is an early event leading to the release of inflammatory mediators that induce endothelial cells adhesion [30] and mediate the extravasation of inflammatory phagocytic cells [31].…”

Section: Discussionmentioning

confidence: 99%

The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells

Montemurro¹,

Nishioka²,

Dundon³

et al. 2002

Eur. J. Immunol.

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Evaluation of antral mast cells in nonulcer dyspepsia

Cited by 37 publications

References 13 publications

Antral Inflammatory Cells, Gastric Emptying, and Electrogastrography in Pediatric Functional Dyspepsia

Antral Inflammatory Cells, Gastric Emptying, and Electrogastrography in Pediatric Functional Dyspepsia

Aminosalicylates and Other Anti-Inflammatory Compounds for Irritable Bowel Syndrome

The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells

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