Evaluation of antitumor activity of peptide extracts from medicinal plants on the model of transplanted breast cancer in CBRB-Rb(8.17)1Iem mice

Tepkeeva, I. I.; Моисеева, Е. В.; Chaadaeva, A. V.; Zhavoronkova, E. V.; Kessler, Y; Семушина, С. Г.; Demushkin, V. P.

doi:10.1007/s10517-008-0119-1

Cited by 17 publications

(20 citation statements)

References 3 publications

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“…Lee et al (2002) showed that the crude water extract of P. lactiflora inhibits growth of both HepG2 and Hep3B cell lines. The extract of I. helenium is cytotoxic to colon, breast, pancreatic, and astrocytoma cancer cell lines (Dorn et al, 2006;Tepkeeva et al, 2008). C. cassia extracts inhibit colon cancer cells and hepatocellular carcinomas, and C. cassia and A. gigas inhibit solid tumor growth (Kwon et al, 1998;Lee et al, 2003Lee et al, , 2007Moon et al, 2006) and induces apoptosis in HL-60 cells (Ka et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation

Bajracharya

Lee

et al. 2009

Arch. Pharm. Res.

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Crude water extracts of 13 traditional Korean medicinal ingredients used for leiomyomal treatment were prepared and used to treat human uterine normal myometrial and leiomyomal cell cultures. All the ingredients inhibited proliferation and altered the morphology of both myometrial and leiomyomal cells. Among the 13 ingredients, n-hexane-, chloroform-, and ethylacetate-soluble fractions were extracted from seven ingredients that potently inhibited cell proliferation in their water extract form. Among these, the ethylacetate-fraction of Phlomis umbrosa and Spatholobus suberectus, and the chloroform-fraction of Curcuma zedoaria and S. suberectus inhibited leiomyomal cell proliferation significantly compared to myometrial cell proliferation. Similarly, immunohistochemical analysis showed the inhibition of transforming growth factor-beta receptor 2 in leiomyomal tissue after treatment with the fractions of the ingredients. Moreover, the chloroform-fraction of C. zedoaria was subfractionated by open column chromatography. Two of the eight subfractions (fractions 6 and 7) potently inhibited cell proliferation in leiomyoma compared to myometrium. Further study will be performed with the goal of isolating specific compounds from two effective subfractions of C. zedoaria, ethylacetate-fraction of P. umbrosa, and the ethylacetate and chloroform-fractions of S. suberectus. The present study may be helpful in developing an alternative remedy to leiomyoma with minimal side-effects compared to the current treatments.

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Section: Discussionmentioning

confidence: 99%

Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation

Bajracharya

Lee

et al. 2009

Arch. Pharm. Res.

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“…Antitumor effects of peptide extracts from H. perforatum and a mixture of Chelidonium majus L., Inula helenium L., Equisetum arvense L., and Inonotus obliquus on slowly growing mammary adenocarcinoma in CBRB-Rb have also been studied. The antitumor effect of a single injection of the test peptides was evaluated by the delay of the appearance and growth of palpable breast cancer in mice over 4 weeks and exhibited maximum activity (Tepkeeva et al, 2008).…”

Section: Antitumor Activitymentioning

confidence: 99%

Phytochemistry, pharmacology and medicinal properties of Hypericum perforatum L.

Asgarpanah¹

2012

Afr. J. Pharm. Pharmacol.

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Hypericum perforatum is known as St. John's Wort. H. perforatum extracts and essential oil are important in drug development with numerous pharmacological activities around the world, including Iran. For a long time, H. perforatum has been used in traditional medicines for healing skin wounds, eczema, burns, diseases of the alimentary tract, and psychological disorders especially depression. H. perforatum has recently been shown to have antioxidant, anticonvulsant, analgesic, anti-inflammatory, cytotoxic and antidiabetic activities. Hypericin, pseudohypericin, hyperoside, rutin, quercetin and hyperforin are the main compounds which are reported in this plant. α-Pinene, caryophyllene, caryophyllene oxide, germacrene D and 2-methyloctane were identified as the major constituents for H. perforatum essential oil collected from different parts of the world. Due to the easy collection of the plant, its widespread and also remarkable biological activities, this plant has become a medicine worldwide. This review presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of H. perforatum at preclinical and clinical levels.

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“…Peptide extracts were prepared as described previously [3,4] and quantitatively characterized by methods of amino acid and carbohydrate analysis [1,2]. According to quantitative amino acid analysis, extracts primarily consisted from peptides (85-95%) and contained less than 5-10% carbohydrates.…”

Section: Peptidementioning

confidence: 99%

Cytostatic Activity of Peptide Extracts of Medicinal Plants on Transformed A549, H1299, and HeLa Cells

et al. 2009

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Biological activity of peptide extracts of medicinal plants was studied on transformed non-small-cell lung carcinoma A549 cells, lung cancer H1299 cells, and cervical cancer HeLa cells at various cell densities. Cell survival and proliferation were evaluated 72 h after treatment with extracts in concentrations of 0.05, 0.25, and 0.5 microg/microl. The cytostatic effect was produced by peptide extracts of Camelia sinesis Kuntze, Inonotus obliquus, and a mixture Inula helenium L., Chelidonium majus L., Equisetum arvense L., and Inonotus obliquus. Peptide extracts of Hypericum perforatum L. and Laurus nobilis L. in the same concentrations had no effects on proliferative activity and growth of tumor cells.

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Evaluation of antitumor activity of peptide extracts from medicinal plants on the model of transplanted breast cancer in CBRB-Rb(8.17)1Iem mice

Cited by 17 publications

References 3 publications

Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation

Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation

Phytochemistry, pharmacology and medicinal properties of Hypericum perforatum L.

Cytostatic Activity of Peptide Extracts of Medicinal Plants on Transformed A549, H1299, and HeLa Cells

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