Evaluation of antioxidant status, oxidative stress and serum trace mineral levels associated with Babesia ovis parasitemia in sheep

Esmaeilnejad, Bijan; Tavassoli, Mousa; Asri‐Rezaei, Siamak; Dalir‐Naghadeh, Bahram; Malekinejad, Hassan; Jalilzadeh-Amin, Ghader; Arjmand, Jafar; Golabi, Mostafa; Hajipour, Naser

doi:10.1016/j.vetpar.2014.07.005

Cited by 30 publications

(26 citation statements)

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“…These results agree with those reported earlier in sheep suffering from babesiosis [34, 53], in cattle suffering from theileria [31, 54] and in people suffering from malaria [24, 55, 56]. However, Chaudhuri et al [38] found significantly increased SOD and catalase activity in dogs infected with B. gibsoni .…”

Section: Discussionsupporting

confidence: 91%

“…Since there was just one severely anaemic dog, it was impossible to fully complete the comparison of anaemia with the investigated biomarkers, but it could be postulated that changes in severely anaemic dogs would be more prominent than those in moderately and mildly anaemic dogs. These results agree with those obtained in sheep with babesiosis and cattle suffering from theileriosis [31, 34, 53]. …”

Section: Discussionsupporting

confidence: 91%

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Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis

et al. 2017

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BackgroundCanine babesiosis is caused by species of the Babesia genus and has become an emerging disease worldwide. To the authors’ knowledge there are no reports in which antioxidants have been analyzed in different presentations of canine babesiosis or in which the prognostic value of antioxidants has been studied. The aim of this study was to evaluate whether oxidative stress could be related to the severity and outcome of canine babesiosis. For this purpose a profile consisting of four antioxidant biomarkers (superoxide dismutase - SOD, glutathione peroxidase - GPx, catalase, total antioxidant status - TAS) and malondialdehyde - MDA as an oxidant biomarker (previously evaluated, here studied for comparative purposes) were evaluated in dogs with canine babesiosis of different clinical severity and outcomes.ResultsThe study was conducted with a sample of 40 dogs suffering from babesiosis (further divided into uncomplicated, one complication and multiple organ dysfunction syndrome - MODS group) and 30 healthy dogs (control group). Additionally, the babesiosis group was divided according to the anaemia into non-anaemic, mildly anaemic, moderately anaemic and severely anaemic dogs. The results of our study showed significantly decreased SOD, catalase and TAS values in diseased dogs compared to controls, while there were no significant differences in GPx between these groups. Dogs that developed MODS showed lower activities of SOD and GPx and higher MDA values compared to dogs with uncomplicated babesiosis as well as with dogs that developed one complication. Superoxide dismutase, catalase and GPx were negatively correlated whereas MDA was positively correlated with the lethal outcome of the disease. Furthermore, this study detected more pronounced decrease in antioxidant biomarkers (SOD, GPx and catalase) in dogs with moderate anaemia compared to those with mild anaemia.ConclusionsThe results of this study showed changes in biomarkers related to the antioxidant status of dogs naturally infected with B. canis canis. These biomarkers could be used as indicators of disease severity and outcome in dogs suffering from babesiosis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-017-1020-9) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis

et al. 2017

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“…The determination of oxidative stress has become important recently in clinical practice as a complementary component ( 8 ). The occurrence of oxidative stress is proven under various conditions such as sepsis, mastitis, enteritis, respiratory and joint disease, endoparasitic diseases, transportation, and pregnancy in ruminants, and oxidative stress should be considered for the prognosis and effective treatment procedure of these conditions ( 2 , 4 , 18 , 21 , 26 , 30 ). There are limited studies which evaluate oxidative stress in sheep mange ( 13 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of oxidative stress in sheep infected with Psoroptes ovis using total antioxidant capacity, total oxidant status, and malondialdehyde level

Aktaş

Kandemir

Kirbaş

et al. 2017

Journal of Veterinary Research

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IntroductionThe study aimed at evaluating oxidative stress using malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) markers in sheep naturally infected with Psoroptes ovis(Acari).Material and MethodsThe study was performed on 40 sheep divided into two equal groups: a healthy group (group I) and a group naturally infected with Psoroptes ovis (group II). The sera were obtained by centrifuging blood samples collected from the vena jugularis and serum MDA level changes in the samples were measured spectrophotometrically. Commercially available test kits were used for the measurement of TAC and TOS levels. The percentage ratio of TOS level to TAC level was accepted as OSI.ResultsThe serum malondialdehyde, total oxidant status levels, and oxidative stress index increased significantly (P < 0.01) in group II, while the serum total antioxidant capacity levels decreased significantly (P < 0.01) in this group. Negative correlations between total antioxidant capacity and total oxidant status and total antioxidant capacity and malondialdehyde, and a positive correlation between total oxidant status and malondialdehyde were found in infected sheep.ConclusionThe obtained results indicated the relationship between oxidant/antioxidant imbalance and Psoroptes ovis infection in sheep. Their MDA, TAC, TOS, and OSI markers may be used to determine the oxidative stress in natural infections with Psoroptes ovis.

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“…The function of antioxidant enzymes has to some extent been studied in ruminant hosts infected with the blood protozoan parasites [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Iron Supplementation on the Growth Rate and Antioxidant Activity of Trichomonas vaginalis

Razavi¹,

Foroudi²,

Rakhshandehroo³

et al. 2017

J Vet Sci Technol

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Trichomonas vaginalis is a common protozoan parasite found in females and males worldwide. The parasite causes mild to severe inflammations in the urogenital tract. This study was conducted to evaluate the effect of iron excess on the growth rate and the activity of antioxidant enzymes in T. vaginalis. The parasite was cultured in Diamond's Trypticase Yeast Maltose (TYM) media with and without iron supplementation and assessed at 2, 3, 5, 7, 9, 11, 13 and 15 days post inoculation (dpi). The results showed significant higher numbers of the parasite in medium with iron supplementation. Furthermore, our findings revealed higher activities of antioxidant enzymes (SOD, GPX and CAT) in parasites cultured with iron supplementation. In conclusion, the present experiment showed that iron increased not only the multiplication rate but also the antioxidant activities of T. vaginalis. It seems that iron could protect T. vaginalis from toxic oxygen metabolites during tissue invasion and helps the parasite to maintain its pathogenicity for the host.

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Evaluation of antioxidant status, oxidative stress and serum trace mineral levels associated with Babesia ovis parasitemia in sheep

Cited by 30 publications

References 26 publications

Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis

Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis

Evaluation of oxidative stress in sheep infected with Psoroptes ovis using total antioxidant capacity, total oxidant status, and malondialdehyde level

The Effects of Iron Supplementation on the Growth Rate and Antioxidant Activity of Trichomonas vaginalis

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