Evaluation of Antioxidant Potential and Cytotoxic
Behavior of Different Varieties of &lt;i&gt;Allium sativum&lt;/i&gt;

Anjum, Fouzia; Shahid, Muhammad; Jilani, Muhammad Idrees; Oranab, Sadaf; Farooq, Saqib; Nazir, Arif; Naz, Saima; Iqbal, Munawar

doi:10.15244/pjoes/116106

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…It contains bioactive compounds that exhibit antimicrobial, antiinflammatory, anticancer, and antioxidant activities. 7 A. sativum is considered one of the most important herbs to promote good health. Allicin (diallyl thiosulfinate) is the most important component of A. sativum, and its efficacy against a wide spectrum of Gram-negative and Gram-positive bacteria was studied.…”

Section: Introductionmentioning

confidence: 99%

Biofilm Inhibition and Antibacterial Potential of Different Varieties of Garlic (Allium sativum) Against Sinusitis Isolates

et al. 2021

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Sinusitis or rhinosinusitis is inflammation of the paranasal sinuses which can be due to autoimmune, allergy, and infection problems. Current study was aimed to evaluate the antibiofilm and antibacterial potential of different varieties of A sativum. Four different varieties (China white, China pink, Desi white, and Desi pink) were used and extracted with methanol and water. Results of antioxidant analysis of A sativum extracts showed that all varieties of garlic have considerable quantity of flavonoids with significant DPPH inhibition and reductive potential. Antibacterial activity of A sativum extracts was tested against different Gram negative and Gram-positive sinusitis isolates. All the sinusitis isolates were susceptible to both methanolic and aqueous extracts of different varieties of A sativum with least MIC values. Antibiofilm potential of extracts against sinusitis isolates was evaluated through crystal violet assay, and all extracts of A sativum were significantly effective against destruction of microbial biofilm. In summary, A sativum extracts possess effective antibacterial and antibiofilm activity against sinusitis isolates and can be utilized for prevention of drug resistance against sinusitis infections and further evaluation is necessary.

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Section: Introductionmentioning

confidence: 99%

Biofilm Inhibition and Antibacterial Potential of Different Varieties of Garlic (Allium sativum) Against Sinusitis Isolates

et al. 2021

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“…CT‐DNA (calf thymus) is commonly used to determine DNA damage protection potential of extracts. Fenton's reagent is used to generate oxidative stress (Anjum et al, 2020 ).…”

Section: Bioassays For Phytobioactive Compoundsmentioning

confidence: 99%

“…Bioactive compounds of plants have remarkable potential to treat diseases (Hussain et al, 2018). Secondary metabolites, such as phenolics, flavonoids, alkaloids, saponins, and terpenoids produced by plants, are the constituents of plant's defense system but they have remarkable potential to treat various diseases (Aanouz et al, 2021;Anjum et al, 2020). Plant extracts have been gaining huge attention to control emerging antibacterial resistance (Abbas et al, 2020;Safdar et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Phytobioactive compounds as therapeutic agents for human diseases: A review

Riaz

Khalid

Afzal³

et al. 2023

Food Science & Nutrition

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Phytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present‐day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, and inflammation. The data for this review were collected from Google Scholar, PubMed, Directory of Open Access Journals (DOAJ), and Science Direct by using keywords: “Medicinal plants, Phytobioactive compounds, Polyphenols, Alkaloids, Carotenoids etc.” Several studies have reported the pharmacological and therapeutic potential of the phytobioactives. Polyphenols, alkaloids, terpenes, and polysaccharides isolated from medicinal plants showed remarkable antioxidant, anticancer, cytotoxic, anti‐inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, and antidiabetic activities. This literature review was planned to provide comprehensive insight into the biopharmacological and therapeutic potential of phytobioactive compounds. The techniques used for the extraction and isolation of phytobioactive compounds, and bioassays required for their biological activities such as antioxidant, antimicrobial, anti‐inflammatory, and cytotoxic activities, have been discussed. Characterization techniques for the structural elucidation of phytobioactive compounds such as HPLC, TLC, FTIR, GC–MS/MS, and NMR have also been discussed. This review concludes that phytobioactive compounds may be used as potential alternative to synthetic compounds as therapeutic agents for the treatment of various diseases.

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Plant Extract-Mediated Synthesis and Antibacterial Potential of Metallic Nanoparticles

Reen,

Sharma,

Kumar

2024

Nanotechnology Based Strategies for Combating Antimicrobial Resistance

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Evaluation of Antioxidant Potential and Cytotoxic Behavior of Different Varieties of <i>Allium sativum</i>

Cited by 8 publications

References 20 publications

Biofilm Inhibition and Antibacterial Potential of Different Varieties of Garlic (Allium sativum) Against Sinusitis Isolates

Biofilm Inhibition and Antibacterial Potential of Different Varieties of Garlic (Allium sativum) Against Sinusitis Isolates

Phytobioactive compounds as therapeutic agents for human diseases: A review

Plant Extract-Mediated Synthesis and Antibacterial Potential of Metallic Nanoparticles

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