Evaluation of Antioxidant Capacity and Synergistic Associations of Quinonemethide Triterpenes and Phenolic Substances from Maytenus ilicifolia (Celastraceae)

Abstract

This work describes the isolation of the secondary metabolites identified as the quinonemethides maytenin (1) and pristimerin (2) from Maytenus ilicifolia extracts obtained from root barks of adult plants and roots of seedlings and their quantification by high performance liquid chromatography coupled to a diode array detector. The electrochemical profiles obtained from cyclic voltammetry and a coulometric detector coupled to high-performance liquid chromatography contributed to the evaluation of their antioxidant capacity. The antioxidant properties of individual components and the crude extracts of the root barks of Maytenus ilicifolia were compared and the possible synergistic associations of quinonemethide triterpenes and phenolic substances were investigated by using rutin as a model phenolic compound.

Antiprotozoal Activity of Quinonemethide Triterpenes from Maytenus ilicifolia (Celastraceae)

“…They accumulate in the stem bark and root barks of some family species [9]. Many biological activities have been reported for members of this class, including antitumor [10], antioxidant [11,12] and trypanocidal [13]. Here, we present the effect of two quinonemethide triterpenes, maytenin ( 1 ) and pristimerin ( 2 ) [14], on the viability of Leishmania promastigotes and intracellular amastigotes and of T. cruzi epimastigotes.…”

Production of the Quinone-Methide Triterpene Maytenin byIn VitroAdventitious Roots ofPeritassa campestris(Cambess.) A.C.Sm. (Celastraceae) and Rapid Detection and Identification by APCI-IT-MS/MS

“…Therefore, QMTs are considered chemotaxonomic indicators of this family [1, 2]. These terpenes display a wide range of biological activities such as anti-inflammatory [3], antioxidant [4, 5], antifungal [6], antitrypanosomal [7], antimicrobial [8], and mainly antitumor action. Recently, attention has been focused on the QMT maytenin, because it is highly toxic to a panel of cancer cell lines (Table 1).…”

In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris

“…The synergism effects of GLE-CVE may be owed to the interaction between the endogenous phytochemicals in it. Since the synergistic interactions of triterpenes/phenolics [ 34 ] and carotenoids/phenolics [ 35 ] were observed previously. While the exact phytochemicals interactions which may be occurred after mixing CVE with GLE need to further analyses and investigations.…”