Evaluation of Antioxidant and Antibacterial Properties of Magnolia champaca L (Magnoliaceae) Stem Bark Extract

Abstract

The current study was designated to explore the antioxidant and antibacterial properties of the methanolic extract of Magnolia champaca stem bark and its different fractions. Antioxidant activity was assessed using total antioxidant capacity, ferric reducing power, DPPH, hydroxyl and hydrogen peroxide scavenging assay. Antibacterial activity was evaluated against five gram positive and five gram negative bacteria using disc diffusion assay method. Among the different fractions, chloroform fraction (CHF) and ethyl acetate fraction (EAF) showed the highest antioxidant activity whereas aqueous fraction (AQF) showed lowest activity in DPPH radical scavenging assay with IC50 of 12.12, 22.41 and 55.16 μg/ml, respectively. Both of the extracts CHF and EAF also exhibited highest total antioxidant capacity, ferric reducing power and hydrogen peroxide scavenging activity with concentration dependent manner when compared to standard BHT. Moderate to potent antibacterial activity was observed against all tested organisms compared to standard azithromycin. The results from the present study revealed that the different fractions of stem bark of M. champaca specially CHF and EAF possess antioxidant and antibacterial property which support its use in traditional medicine and suggesting that the plant may be further investigated to discover its pharmacologically active natural products.
 Bangladesh Pharmaceutical Journal 23(2): 96-102, 2020

Qualitative and quantitative phytochemical analysis of methanolic extract of Magnolia champaca leaves

“…champaca commonly known as champak/chembakam is an evergreen tropical tree known for their scented flowers. Traditionally the plant parts were used for their beneficial activity against nausea, haemolysis, leprosy, ulcers, gout, cough, bronchitis, malaria and dysmenorrhea (Sinha and Varma, 2017).The plant possessed diverse pharmacological activities like antioxidant (Hasan et al, 2020), antimicrobial (Daphedar et al, 2020), schizonticidal (Mehrotra et al, 2017), spasmolytic, air-way relaxing and vasodilating potential (Saqib et al, 2018). Yesmin et al (2021) established the antineoplastic potential of M. champaca bark methanolic extract against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.…”

Unveiling the therapeutic potential: Evaluation of anti-inflammatory and antineoplastic activity of Magnolia champaca Linn’s stem bark isolate through molecular docking insights

“…is used in Asian countries as a traditional medicinal plant that belongs to the Magnoliaceae family and has been used for the treatment and cure of several diseases, such as diarrhea, common cold symptoms, hypertension, gastric disorder and dyspepsia, fever, rheumatism and pain, abscesses and infections, dysmenorrhea and inflammation [ 14 , 15 ]. The plant has been investigated by researchers, especially the bark, for its antioxidant, antimicrobial, and hypoglycemic activities [ 16 ], but no significant study has evaluated the anti-inflammatory or antineoplastic potential of the stem bark part of the plant, nor has any active compound responsible for such activity been reported from the plant part.…”