Evaluation of Antioxidant and Antiangiogenic Properties of Caesalpinia Echinata Extracts

Abstract

Natural products contain important combinations of ingredients, which may to some extent help to modulate the effects produced by oxidation substrates in biological systems. It is known that substances capable of modulating the action of these oxidants on tissue may be important allies in the control of neovascularization in pathological processes. The aim of this study was to evaluate the antioxidant and antiangiogenic properties of an ethanol extract of Caesalpinia echinata. The evaluation of antioxidant properties was tested using two methods (DPPH inhibition and sequestration of nitric oxide). The antiangiogenic properties were evaluated using the inflammatory angiogenesis model in the corneas of rats. The extract of C. echinata demonstrated a high capacity to inhibit free radicals, with IC50 equal to 42.404 µg/mL for the DPPH test and 234.2 µg/mL for nitric oxide. Moreover, it showed itself capable of inhibiting the inflammatory angiogenic response by 77.49%. These data suggest that biochemical components belonging to the extract of C. echinata interfere in mechanisms that control the angiogenic process, mediated by substrates belonging to the arachidonic acid cascade, although the data described above also suggest that the NO buffer may contribute to some extent to the reduction in the angiogenic response.

Homoisoflavonoids from Caesalpinia spp.: A Closer Look at Chemical and Biological Aspects

“…The existence of these compounds is associated to the genus Caesalpinia involving species as C. pulcherrima [19,20], C. echinata [1,21,22], C. bonduc [3], C. sappan [4,[23][24][25][26][27][28], C. japonica [29], and C. milletti [30]. However, the diversity of compounds (in number and structurally) is associated to C. sappan, a prolific source of homoisoflavonoids with important ethnopharmacological applications.…”

“…The species C. echinata has also demonstrated antitumor effect in vivo against cells strains of Ehrlich Carcinoma and Sarcoma 180. In addition, an interesting antiangiogenic effect was noticed[21]. On the other hand, compound 14, an oxidation product of brazilin, was considered effective against the inflammatory and cytotoxic processes[22].…”

CN‐3 increases TMZ sensitivity and induces ROS‐dependent apoptosis and autophagy in TMZ‐resistance glioblastoma

“…[ 55 ] Natural products are a rich source of new drug research and development, and play an important role in cancer treatment. [ 56 ] An important source of natural drug development comes from marine natural products. [ 57,58 ] Saponins are active ingredients in many plants and animals and more than 150 saponins have been reported to have anticancer effects.…”

Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study

“…Various studies have investigated the effects of the sea cucumber components, including polysaccharides, which exhibited a variety of biological activities, such as anti-tumor ( 54 ), anti-oxidation ( 55 , 56 ) and anti-apoptotic ( 35 ) activities. Chenghui et al ( 57 ) and Chen et al ( 58 ) investigated the antioxidant properties of peptides and hydrolysates extracted from different species of sea cucumbers and found that hydrolysates have a considerable antioxidant activity, which may be associated with the presence of antioxidant peptides.…”