Evaluation of antioxidant activity of chlorogenic acids and coffee extracts by an electrochemical DNA-based biosensor

Tomac, Ivana; Šeruga, Marijan; Labuda, Ján

doi:10.1016/j.foodchem.2020.126787

Cited by 55 publications

(28 citation statements)

References 35 publications

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“…Thus, it is possible to conclude that the phenolic profile, particularly the richness in rutin, quercetin and chlorogenic acid, is potentially responsible for the antioxidant properties and scavenging ability of A. arguta fruit pulp against ROS and RNS [4,33–35] …”

Section: Resultsmentioning

confidence: 99%

Actinidia arguta Pulp: Phytochemical Composition, Radical Scavenging Activity, and in Vitro Cells Effects

Pinto

Sut

Dall’Acqua

et al. 2021

Chemistry & Biodiversity

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Hardy kiwifruit (Actinidia arguta) is a highly appreciated exotic fruit endowed with outstanding bioactive compounds. The present work proposes to characterize the pulp from A. arguta organic fruits, emphasizing its radicals scavenging capacity and effects on intestinal cells (Caco‐2 and HT29‐MTX). The physicochemical properties and phenolic profile were also screened. The total phenolic and flavonoid contents (TPC and TFC, respectively) of pulp were 12.21 mg GAE/g on dry weight (DW) and 5.92 mg CE/g DW, respectively. A high antioxidant activity was observed (FRAP: 151.41 μmol FSE/g DW; DPPH: 12.17 mg TE/g DW). Furthermore, the pulp did not induce a toxic effect on Caco‐2 and HT29‐MTX cells viability up to 1000 μg/mL. Regarding in vitro scavenging capacity, the pulp revealed the highest scavenging power against NO. (IC50=3.45 μg/mL) and HOCl (IC50=12.77 μg/mL). These results emphasize the richness of A. arguta fruit pulp to be used in different food products.

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Section: Resultsmentioning

confidence: 99%

Actinidia arguta Pulp: Phytochemical Composition, Radical Scavenging Activity, and in Vitro Cells Effects

Pinto

Sut

Dall’Acqua

et al. 2021

Chemistry & Biodiversity

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“…Nevertheless, consumption of instant coffee (16 g/d, equivalent to 520 mg CF) for a 3-wk period did not change the plasma and urinary levels of TXB2 and PGE2 [45]. Furthermore, antioxidant activity of coffee products has been reported in the order of Robusta coffee, coffee cherry, Indian green coffee (72%) > CA (71%) > CGAs (70%) > dicaffeoylquinic acids (69%) >> Nescafe Espresso (49%) [46].…”

Section: Discussionmentioning

confidence: 96%

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (<em>Coffea arabica</em>)

Hutachok¹,

Angkasith²,

Chumpun³

et al. 2020

Preprint

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Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet activation and aggregation can lead to thrombosis. We focused on determining the chemical composition, antioxidant activity and inhibitory effects on agonist-induced platelet aggregation and cyclooxygenase (COX) of coffee beverages in relation to their preparation method. We prepared instant coffee and brewed coffee beverages using drip, espresso and boiling techniques. Coffee extracts were assayed for their CF and CGA contents using HPLC, TPC using colourimetry, platelet aggregation with an aggregometer and COX activity using ELISA. The findings have shown all coffee extracts, except the decaffeinated types, contained nearly equal amounts of CF, CGA and TPC. Inhibitory effects of coffee extracts on platelet aggregation differed depending on the activation pathways induced by different agonists. All espresso, drip and boiled coffee extracts caused dose dependent inhibition of platelet aggregation induced by ADP, collagen, epinephrine, and arachidonic acid (ARA). The most marked inhibition was seen at low doses of collagen or ARA. Espresso and drip extracts inhibited collagen-induced platelet aggregation more than purified caffeine or CGA. Espresso, boiled and drip coffee extracts were also a more potent inhibitors of COX-1 and COX-2 than purified caffeine or CGA. We conclude that inhibition of platelet aggregation and COX-1 and COX-2 may contribute to anti-platelet and anti-inflammatory effects of espresso and drip coffee extracts.

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“…Coffee is a major source of chlorogenic acid in the human diet; daily intake in coffee drinkers is 0.5-1.0 g; coffee abstainers will usually ingest < 100 mg for day. Several in vitro studies have suggested the potential beneficial effects of chlorogenic acid on human health, such as antioxidant, antidiabetic, anticarcinogenic, cardioprotective, antibacterial effects, etc (Ludwig et al, 2014b;López-Froilán et al, 2016;Tomac et al, 2020). The dose used in this study (7.2 mL/kg/day) is equivalent to a daily human consumption of 8 cups of 50 mL (400 mL) of boiled and filtered coffee.…”

Section: Bioactive Compoundsmentioning

confidence: 99%

“…As for coffee, the studies are often in conflict. Numerous studies describe the antioxidant properties of coffee, while others show the opposite effect (AlAmri et al, 2020;Chu et al, 2011;Kwak et al, 2017;Tomac et al, 2020;Wu et al, 2011). One of the most widely studied and proven properties of coffee is its antioxidant activity related to natural phenolic compounds such as chlorogenic acid, caffeine and melanoidins, which contributes to the improvement of the pathophysiological characteristics of type 2 diabetes mellitus (T2D) (Butt & Sultan, 2011;Chu et al, 2011).…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Coffee beverage reduces ROS production and does not affect the organism s response against Candida albicans

Silvério

Pereira

Duarte

et al. 2020

Rev. Ciênc. Farm. Básica Apl.

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Evaluation of antioxidant activity of chlorogenic acids and coffee extracts by an electrochemical DNA-based biosensor

Cited by 55 publications

References 35 publications

Actinidia arguta Pulp: Phytochemical Composition, Radical Scavenging Activity, and in Vitro Cells Effects

Actinidia arguta Pulp: Phytochemical Composition, Radical Scavenging Activity, and in Vitro Cells Effects

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (<em>Coffea arabica</em>)

Coffee beverage reduces ROS production and does not affect the organism s response against Candida albicans

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