Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe

Jędrejek, Dariusz; Kontek, Bogdan; Lis, Bernadetta; Stochmal, Anna; Olas, Beata

doi:10.1016/j.cbi.2016.12.003

Cited by 78 publications

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“…In our previous in vitro studies, the standardized alcoholic fractions from petals and leaves of T. officinale (including HCAs and flavone fractions) were found to possess the ability to reduce oxidative stress (i.e., lipid peroxidation, protein carbonylation and protein thiol groups) in human plasma and blood platelets [3,21]. Additionally, dandelion fractions enriched with HCAs, derived from both leaves and petals, were shown to beneficially influence the coagulation activity of blood plasma [3].…”

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“…Additionally, they may also provide health benefits associated with preventing damage to the building elements of the body (DNA, lipids and proteins) due to decreased biological degeneration [16][17][18]. A number of polyphenolic compounds, mainly phenolic acids (hydroxycinnamic acid (HCAs) derivatives) and flavonoids (apigenin and luteolin derivatives) have been identified in the leaves and flowers of dandelions, so far [19][20][21]. Natural bioactive substances with both antioxidative and hypo-cholesterolemic properties, an example of which is chicoric acid, have been found to be effective in preventing the formation and/or progression of atherosclerosis [18,22].…”

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“…Natural bioactive substances with both antioxidative and hypo-cholesterolemic properties, an example of which is chicoric acid, have been found to be effective in preventing the formation and/or progression of atherosclerosis [18,22]. HCAs induce antiradical and protective actions against oxidation processes [3,21,23]; meanwhile, flavonoids inhibit the formation of reactive oxygen and/or nitrogen species by suppressing NO synthase and COX-2 protein expression [16,17,24].In our previous in vitro studies, the standardized alcoholic fractions from petals and leaves of T. officinale (including HCAs and flavone fractions) were found to possess the ability to reduce oxidative stress (i.e., lipid peroxidation, protein carbonylation and protein thiol groups) in human plasma and blood platelets [3,21]. Additionally, dandelion fractions enriched with HCAs, derived from both leaves and petals, were shown to beneficially influence the coagulation activity of blood plasma [3].With increasing evidence of the protective potential of dandelion fractions on the antioxidant status but with scarce data concerning its properties in the systemic vasculature, we aimed to examine whether dandelion fractions from leaves and petals influence, in the same way (i) the antioxidant profile (of internal organs, blood plasma and urine samples); (ii) modify the blood plasma lipids; (iii) glucose and (iv) the intestinal digesta.…”

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“…">Plant MaterialThe leaves and flowers of T. officinale were harvested on a farm located in south-eastern Poland (Rzeszów, 50.114175 • N, 21.911738 • E) in 2015. Dandelion material was freeze-dried, powdered and used for extraction, as previously described [21].…”

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Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

et al. 2020

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Alcoholic leaf and petal fractions of Taraxacum officinale (dandelion) were previously demonstrated to exert in vitro antioxidant and antithrombotic activities in blood plasma and platelets. Eight-week-old male Wistar rats (n = 6) were supplemented for four weeks with dandelion fractions (694 mg/kg of diet = 11.9 ± 0.6 mg daily). Dandelion leaf and petal fractions, which delivered daily 4.10 ± 0.05 and 1.41 ± 0.07 mg l-chicoric acid, respectively, were shown to exert antioxidative actions, measured as decreased levels of thiobarbituric acid-reactive substances (TBARS) in the spleen (≈0.8-fold, leaves and petals), brain (0.53-fold, leaves) and thoracic arteries (0.59-fold, petals). Moreover, petal fraction increased thiols in the blood plasma (1.58-fold), while leaf fraction decreased protein carbonylation levels (0.59-fold). Additionally, dandelion leaf fractions modified the lipid profile: decreased triglyceride (0.44-fold), total cholesterol (0.73-fold), lipoprotein combine index (0.32-fold) and the atherogenic index of plasma (0.62-fold). Dandelion fractions showed a beneficial decrease effect in the participation of cyclooxygenase products in the noradrenaline-induced vascular contractions of thoracic arteries. Meanwhile, only the dandelion leaf fraction augmented acetylcholine-induced vasodilation and upregulated K ATP channels. The heart rate and blood pressure were not modified. Dandelion leaf and petal phenolic fractions, enriched with l-chicoric acid, are promising plant materials that may exert in vivo beneficial antioxidant effects.Antioxidants 2020, 9, 131 2 of 13 as thrombosis and atherosclerosis. Thus, preparations exerting both antioxidant and anticoagulant activities based on safe natural substances are continuously sought after for their potentially wide range of health benefits in the prevention and treatment of cardiovascular disorders [1][2][3][4][5][6][7].Nowadays, the dandelion (Taraxacum officinale) herb and root are used as a component of food products, dietary supplements and pharmacological preparations for various ailments (mainly liver, gallbladder and kidney disorders) [8,9]. This is due to a wide range of biological activities, including antihyperglycemic, antioxidant and anti-inflammatory actions demonstrated by dandelion fractions and their constituents, with no reported adverse effects, together with a well-understood chemical composition and a widespread occurrence of the plant throughout the world [10,11]. Aqueous-organic extracts from the dandelion herb were found to exert an anti-inflammatory action [12], mainly due to decreasing the expression of proinflammatory cytokines by inhibiting the nuclear factor (NF)-κB [13], tumor necrosis factor (TNF)-α and interleukin (IL)-1β [14], as well as reducing the expression and production of inducible nitric oxide synthase/nitric oxide (iNOS/NO) and cyclooxygenase (COX)-2/prostaglandin E2 [15].Plant polyphenols have the ability to protect dietary lipids, proteins and vitamins from oxidation. Additionally, they may also provide health bene...

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confidence: 97%

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confidence: 99%

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confidence: 99%

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Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

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Medicinal Plants from the Balkan Peninsula—From Traditional To Modern Pharmacy/Medicine

Cvetanović

Stupar

Petronijević

et al. 2021

Phytopharmaceuticals

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UPLC–MS/MS study of the effect of dandelion root extract on the plasma levels of the selected irreversible tyrosine kinase inhibitors dasatinib, imatinib and nilotinib in rats: Potential risk of pharmacokinetic interactions

Alzoman

Maher

Shehata

et al. 2019

Biomedical Chromatography

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Tyrosine kinase inhibitor treatments for chronic myeloid leukaemia based on nilotinib (NIL), dasatinib (DAS) and imatinib (IMA) have improved patient quality of life and have turned chronic myeloid leukemia from a fatal disease into a chronic disease.Dandelion is a rich source of phenolic compounds with strong biological properties, and the effects of using this plant in the treatment of different illnesses can be linked to the presence of various polyphenols found in the different parts of the plant. Thus, dandelion can potentially be used as a nutraceutical (dietary antioxidant) to prevent different disorders associated with oxidative stress, i.e. cardiovascular disorders, cancer and inflammatory processes. Mutual interference between a drug and a food constituent may result in altered pharmacokinetics of the drug and undesired or even dangerous clinical situations. In the present study, a bioanalytical ultra performance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS) method was developed and validated for the quantification of DAS, IMA and NIL in rat plasma.Sample preparation was carried out using solid-phase extraction with C 18 cartridges with a good extraction recovery of ≥94.37% for the three drugs. The method was fully validated as per the US Food and Drug Administration guidelines.

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Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe

Cited by 78 publications

References 26 publications

Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

Medicinal Plants from the Balkan Peninsula—From Traditional To Modern Pharmacy/Medicine

UPLC–MS/MS study of the effect of dandelion root extract on the plasma levels of the selected irreversible tyrosine kinase inhibitors dasatinib, imatinib and nilotinib in rats: Potential risk of pharmacokinetic interactions

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