Evaluation of antimutagenic and protective effects of Parkinsonia aculeata L. leaves against H2O2 induced damage in pBR322 DNA

Sharma, Sonia; Sharma, Sushant; Vig, Adarsh Pal

doi:10.1007/s12298-016-0346-2

Cited by 7 publications

(3 citation statements)

References 51 publications

(45 reference statements)

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“…The genus Parkinsonia has been studied for its biological properties. Parkinsonia aculeata has been recognized for its antioxidant, antimutagenic, antibacterial, antifungal, anti-inflammatory and antitumor effects (Saha et al, 2010a;Singh et al, 2013;Al-Youssef and Hassan, 2015;Sharma et al, 2016). Chemical studies on P. aculeata showed that this plant is constituted by essential oils (Al-Youssef and Hassan, 2015), flavonoids and polyphenolic compounds (Abdelaziz et al, 2020), with pharmacological potential.…”

Section: Introductionmentioning

confidence: 99%

Nueva información del perfil de compuestos bioactivos, potencial antioxidante y antiproliferativo de Parkinsonia praecox (Fabaceae)

López-Romero¹,

Torres-Moreno²,

Valencia³

et al. 2022

Acta Bot. Mex.

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Antecedentes y Objetivos: Parkinsonia praecox,“palo brea”, es una planta medicinal distribuida en el Desierto de Sonora en México. Sin embargo, existe poca información acerca de la composición química y del potencial biológico de esta planta. Basado en lo anterior, el objetivo del presente estudio fue determinar la composición química y el potencial antioxidante y antiproliferativo de P. praecox. Métodos: Se prepararon extractos metanólicos de tallos (PPS), frutos (PPB) y flores (PPF). La composición química se determinó a través de los métodos de perfil fitoquímico, Folin-Ciocalteu y UPLC-DAD. La actividad antioxidante se evaluó por los métodos DPPH, ABTS, ORAC y FRAP. La actividad antiproliferativa se determinó por el ensayo MTT contra las líneas celulares A549 (cáncer de pulmón de células no pequeñas), MDA-MB-231 (cáncer de mama triple negativo), PC-3 (cáncer de próstata grado IV), HeLa (cáncer de cervix) y L929 (tejido conectivo subcutáneo no canceroso). Resultados: El perfil fitoquímico mostró la presencia de terpenos, compuestos fenólicos, flavonoides, taninos y azúcares en los extractos. PPS presentó la concentración más elevada (p<0.05) de compuestos fenólicos (65.5 mg GAE/g), identificando y cuantificando quercetina (218.86 µg/g). Además, PPS mostró la capacidad más elevada (p<0.05) para estabilizar a los radicales DPPH (IC50: 137 µg/ml), ABTS (39.56 µM TE/g), hidroxilo (ORAC: 1777.78 µM TE/g), y reducir metales (FRAP: 935.6 µM Fe(II)/g). Un comportamiento similar se observó en la actividad antiproliferativa, ya que PPS mostró la citotoxicidad más elevada (p<0.05): A549 (IC50: 341.3 µg/ml), MDA-MB-231 (IC50: 147.3 µg/ml), PC-3 (IC50: 78.8 µg/ml), HeLa (IC50: 121.6 µg/ml) y L929 (IC50: 93.29 µg/ml).Conclusión: Este es el primer estudio donde se reporta el perfil de compuestos bioactivos y el potencial biológico de P. praecox. Los resultados muestran una fuerte asociación entre la actividad antioxidante y antiproliferativa con la presencia de compuestos fenólicos. Esto representa un potencial soporte para el desarrollo de terapias farmacológicas.

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Section: Introductionmentioning

confidence: 99%

Nueva información del perfil de compuestos bioactivos, potencial antioxidante y antiproliferativo de Parkinsonia praecox (Fabaceae)

López-Romero¹,

Torres-Moreno²,

Valencia³

et al. 2022

Acta Bot. Mex.

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“…The chemical constituents from the leaf extract 9 of the title plant were orientin, iso-orientin, vitexin, 10,11 isovitexin, leucenin-II, vicenin-II, apigenin, luteolin, kaempferol, chrysoeriol, diosmotin-6-βglucoside, a new flavanone, parkintin with epoxy isopentyl moiety and permethylated 5-C-hexosylluteolin. P. aculeata was reported to possess antimicrobial, 12 antigenotoxic, 13 antidiabetic, 14,15 antioxidant, 16 antimutagenic, 17 antiinflammatory, 18 hepato-protective 19 and antitumor activities 20,21 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2020

IJPSR

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Parkinsonia aculeata (family-Caesalpiniaceae) is a large spinous shrub found in warmer regions of the world. It is a well known medicinal plant that has significant and promising biological activities such as antioxidant, anti-inflammatory, antidiabetic, antispermatogenic, etc. The phytochemical investigations of the leaves, flowers, and stem have revealed the presence of various glycosides, flavonoids, reducing sugars, alkaloids, sterols, tannins, volatile oils, and saponins. The various biological activities and potent phytoconstituents of the plant indicate its therapeutic potential efficacy. The present study shows the detailed investigation of the methanolic stem bark extract of the title plant. From the methanolic stem bark extract of the title plant 1-cyclohexyltridec-1ene (new compound A), 6-hydroxypentacosylpentanoate (B), α-amyrin acetate (C), α-amyrin (D) and β-sitosterol (E) were isolated with the help of column chromatographic technique and characterized on the basis of different spectral studies i.e., 1 H NMR, 13 C NMR, IR, and Mass spectroscopy.

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“…Therefore, a great quantity polyphenols can be found in such marketed foods and drugs containing these fruits and herbs (Liu and Henkel, 2002). Polyphenols have been confirmed as various biological activities, including antioxidation (Mertens-Talcott et al, 2017), anti-inflammation (Oliviero et al, 2018), antibacterial (Smullen et al, 2007), and treatments of burns, mutations (Sharma et al, 2016), and cardiovascular diseases (Carluccio et al, 2003). At present, the development of foods, health products, and pharmaceuticals containing polyphenols has aroused wide concerns.…”

Section: Introductionmentioning

confidence: 99%

Exploration on the Approaches of Diverse Sedimentations in Polyphenol Solutions: An Integrated Chain of Evidence Based on the Physical Phase, Chemical Profile, and Sediment Elements

et al. 2019

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Triphala is a famous herbal formula originated in Asia and is popular in America. Due to the high abundance of polyphenols, its oral liquid is unstable and easy to cause precipitate, which results in the loss of activities. However, complex composition and unclear precipitation mechanism hinders the improvement of stability. In this study, the accumulation of precipitation in the storage and its effect on activity were investigated. Then, an integrated chain of evidence was proposed based on the physical phase, chemical profile, and sediment elements. The results showed that antioxidant activity decreased from IC50 115 to 146 μl before and after 90 days of storage, and the anti-fatigue activity decreased from 30.54 to 28.47 min. Turbiscan Lab Expert observed that particle size increased from 106 to 122 nm, and the turbiscan stability index increased from 0 to 14, which indicated that its stability is continuously decreasing. High performance liquid chromatography (HPLC) fingerprint coupled with multivariate statistical analysis identified that these chemical markers changed significantly, such as gallic acid, catechins, and ellagic acid. Loss of catechins tends to be involved in the formation of phlobaphene precipitation. The fact that the new-born ellagic acid in precipitation (0.47 mg/ml) is significantly higher than that reduced in solution (0.25 mg/ml) indicates that it is not only derived from colloid aging. Microscopic observation combined with energy spectrum analysis further confirmed the existence of the multi-precipitates. The crystalline precipitate is ellagic acid, and the other is phlobaphene. In conclusion, based on the evidence chain analysis, this study revealed a systematic change of the whole polyphenol solution system. It provides a novel perspective to understand the sedimentation formation of polyphenol solution, which is an important theoretical contribution to the preparation of polyphenol solutions.

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Evaluation of antimutagenic and protective effects of Parkinsonia aculeata L. leaves against H2O2 induced damage in pBR322 DNA

Cited by 7 publications

References 51 publications

Nueva información del perfil de compuestos bioactivos, potencial antioxidante y antiproliferativo de Parkinsonia praecox (Fabaceae)

Nueva información del perfil de compuestos bioactivos, potencial antioxidante y antiproliferativo de Parkinsonia praecox (Fabaceae)

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Exploration on the Approaches of Diverse Sedimentations in Polyphenol Solutions: An Integrated Chain of Evidence Based on the Physical Phase, Chemical Profile, and Sediment Elements

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