Evaluation of Antimicrobial Properties of Herbal Ointments Formulated With Ethanolic Extract of Acalypha Wilkesiana

Abstract

The antimicrobial activity of ethanolic extract of dried fresh leaves of Acalypha wilkesiana and also those of the ointments formulated with the extract was evaluated. The preliminary in vitro antimicrobial activity of the extract at concentrations of 2.5 mg/ml, 5 mg/ml and 10 mg/ml and those of the ointments was determined against MIC values of the extract against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, andCandida albicans were 5.00, 1.25, 10.00 and 5.00 mg/ml respectively. The formulation containing Acalypha wilkesiana extract in emulsifying ointment showed better antibacterial activity than the simple ointment. The herbal ointment also compared favourably with a commercial brand of Funbact A ® cream. This study shows that ethanolic extract of Acalypha wilkesiana has both antibacterial and anti-candidal activity and also has high potential as antimicrobial agent when formulated as ointment for topical use.

Formulation and Evaluation of Antimicrobial Activities of Herbal Cream Containing Ethanolic Extracts of Azadirachta indica Leaves and Aloe Vera Gel

“…The issue of resistance of dermatological infections to some medicaments available in the market has sparked up interest in the research of the antimicrobial properties of drugs from natural sources which are active against the major causative organisms of skin infections [2,3]. Drug resistant strains are causing severe problems in many infections including skin infections such as carbuncles, folliculitis, impetigo, and burn wound sepsis.…”

Evaluation of Acute and Sub-Chronic Toxicities and the Effect of Ointment Bases on the Antimicrobial Potency of the Ethanolic Extracts of Alchornea cordifolia Leaf and Terminalia superba Stem Bark

“…Table 1). The white ointment base and the lanolin base were prepared using the fusion method described by Azubuike et al 4 The hydrous lanolin ointment base and soft water washable base were prepared by melting the oleaginous phase separately in a melting pan at 70ºC and heating the aqueous phase in another melting pan to 70ºC. The aqueous portion was then added to the oleaginous phase with continuously stirring until congealed.…”

“…al. 4 In-vitro antimicrobial efficacy of the formulated ointments was carried out using the agar diffusion method. 22…”

“…3 Apart from the problem of resistance, environmental degradation, cost and pollution associated with irrational use of orthodox medicines have necessitated renewed interest in the use of medicinal plants as sources of effective and safer alternatives in the management of human infections. 4 Plants occupy a very important place in modern medicine as they are used as either raw materials for drugs or as a template for discovery and synthesis of drugs. 5 According to the World Health Organization 2 , medicinal plants can provide the best alternative source for obtaining a variety of drugs, since they possess a variety of bioactive principles known as *Corresponding author.…”

Preparation and Characterization of Polyurethane Nanocapsules Containing Cassia alata Linn. Extract

“…It is employed for the treatment of Manuscript received August 9, 2014 ringworm and other fungal infections of the skin. The antibacterial activity of crude extract was predominantly against Gram-positive organisms [6]- [9]. Therefore, in the present work, extracts of Cassia alata leave were applied as the core of nanocapsules to enhance antibacterial function.…”