Evaluation of antimicrobial efficacy of Triphala (an Indian Ayurvedic herbal formulation) and 0.2% chlorhexidine against Streptococcus mutans biofilm formed on tooth substrate: An in vitro study

Prabhakar, J.; Balagopal, Shwetha; Priya, M S; Selvi, S Senthamil; Senthilkumar, M.

doi:10.4103/0970-9290.142539

Cited by 22 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Examining the use of Triphala as an oral antimicrobial agent, one study reported that Triphala dissolved in 10% DMSO exhibited a significant antibacterial effect ex vivo on extracted human mandibular premolars against Streptococcus mutans , which is one of the most prevalent oral pathogens responsible for dental cavities. 44 …”

Section: Therapeutic Uses and Studiesmentioning

confidence: 99%

Therapeutic Uses ofTriphalain Ayurvedic Medicine

Peterson

Denniston

Chopra

2017

The Journal of Alternative and Complementary Medicine

247

156

View full text Add to dashboard Cite

Aim: The aim of this article is to review the current literature on the therapeutic uses and efficacy of Triphala. Herbal remedies are among the most ancient medicines used in traditional systems of healthcare such as Ayurveda. Triphala, a well-recognized and highly efficacious polyherbal Ayurvedic medicine consisting of fruits of the plant species Emblica officinalis (Amalaki), Terminalia bellerica (Bibhitaki), and Terminalia chebula (Haritaki), is a cornerstone of gastrointestinal and rejuvenative treatment.Methods: A search of the PubMed database was conducted.Results: In addition, numerous additional therapeutic uses described both in the Ayurvedic medical literature and anecdotally are being validated scientifically. In addition to laxative action, Triphala research has found the formula to be potentially effective for several clinical uses such as appetite stimulation, reduction of hyperacidity, antioxidant, anti-inflammatory, immunomodulating, antibacterial, antimutagenic, adaptogenic, hypoglycemic, antineoplastic, chemoprotective, and radioprotective effects, and prevention of dental caries. Polyphenols in Triphala modulate the human gut microbiome and thereby promote the growth of beneficial Bifidobacteria and Lactobacillus while inhibiting the growth of undesirable gut microbes. The bioactivity of Triphala is elicited by gut microbiota to generate a variety of anti-inflammatory compounds.Conclusions: This review summarizes recent data on pharmacological properties and clinical effects of Triphala while highlighting areas in need of additional investigation and clinical development.

show abstract

Section: Therapeutic Uses and Studiesmentioning

confidence: 99%

Therapeutic Uses ofTriphalain Ayurvedic Medicine

Peterson

Denniston

Chopra

2017

The Journal of Alternative and Complementary Medicine

247

156

View full text Add to dashboard Cite

show abstract

“…Triphala is a powder that consists of equal parts of Emblica officinalis, Terminalia chebula, and Terminalia belerica [ 130 ]. In dentistry, it has been used because of their antimicrobial [ 131 , 132 ], antiplaque [ 133 ], antigingivitis [ 133 ], anticariogenic [ 134 ] and anti-collagenase properties [ 135 ]. Shakouie et al compared the antimicrobial efficacy of triphala with various concentrations of NaOCl against E. faecalis and reported that triphala exhibited better antimicrobial activity against E. faecalis when compared to 0.5 and 1% NaOCl [ 131 ].…”

Section: Triphalamentioning

confidence: 99%

Natural Therapeutic Options in Endodontics - A Review

Nagendrababu¹,

Anand²,

Abarajithan³

et al. 2016

TODENTJ

View full text Add to dashboard Cite

Complete eradication of microbial biofilms and elimination of the smear layer are the key factors during endodontic treatment. Various chemical irrigants have been proposed in the literature for the same. The major setback with these chemical irrigants is that they are not bio-friendly to the dental and peri-radicular tissues. In the recent years, research to use natural products for root canal disinfection has gained importance. The aim of this article is to compile various herbal products that have been used as an irrigants and intracanal medicaments in the field of Endodontics to eradicate the biofilm and remove smear layer.

show abstract

“…The dried powders A. arabica (bark), T. Chebula (fruits), T. bellerica (fruits) and E. officinalis (fruits) plants have been used in traditional tooth powder formulation in India for more than 100 years (unpublished). Already many reports are available for the validation of numerous of potential benefits of these four plant material including anti-cariogenic properties [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] and these plant materials possess abundance of bioactive compound like quercetin, luteolin, saponins, anthraquinones, amino acids, fatty acids, various carbohydrates and polyphenols such as chebulinic acid which can exhibit the antimicrobial activities [34] , [35] . The above four plant materials used in this study having the potential to protect users against oral diseases, but this potential and the possible mechanism has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial effect of herbal extract of Acacia arabica with triphala on the biofilm forming cariogenic microorganisms

Ramalingam

2020

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

Background Dental caries is a biofilm-related infectious disease with a multifactorial etiology, over five billion inhabitants have affected worldwide due to this disease. Objective Antimicrobial efficacy of a mixed herbal powder extract (MHPE) against cariogenic microorganisms was investigated. Materials and methods MIC, MBC, kinetics of killing, biofilm disruption and anticaries effect of MHPE were determined. For biofilm disruption, biofilms of Streptococcus mutans, Lactobacillus casei, Actinomyces viscosus and Candida albicans were treated with MHPE for 30 min and attached cells were quantified after staining. For live/dead staining biofilm assay, S. mutans biofilm treated with MHPE for 1min, 5min and 1 h was examined with confocal laser scanning system after live/dead staining. Efficacy was experimented by structural quality using Scanning Electron Microscope (SEM). Anticaries effect was determined by formation of caries-like lesion in continuous flow biofilm model. Results MHPE exhibited inhibition zones ranging from 12.5 to 24.0 mm. The highest inhibition zone was recorded at concentration of 50 μg/ml. MIC for S. mutans was between 12.23 and 36.7 μg/ml, while the MBC values ranged from 36.7 to 110.65 μg/ml. Inhibitory concentration of MHPE was three fold higher than CHLX. Significant reduction of cell count (49–95%) was observed with increasing time and higher concentration. Percentage biofilm reduction compare with negative control was 96.9% ( A. viscosus) , 94% ( C. albicans) , 99.8% ( L. casei) and 91.7% ( S. mutans) . For MHPE-treated biofilm, live/dead staining demonstrated significant (p < 0.05) higher in deceased red fluorescence areas in all kinetics points from 53.6% (1min) to 85% (1h). SEM confirmed the damage in the outer layers of S. mutans. MHPE has components with effective antibacterial activity against caries-inducing microorganisms. Conclusion The anti-adherence and anti-biofilm effect as well as the faster killing activity suggests that MHPE formula has effective antibacterial activity and could be a useful source of anti-cariogenic agents in near future.

show abstract

Evaluation of antimicrobial efficacy of Triphala (an Indian Ayurvedic herbal formulation) and 0.2% chlorhexidine against Streptococcus mutans biofilm formed on tooth substrate: An in vitro study

Abstract: Triphala showed statistically significant antibacterial activity against S. mutans biofilm formed on tooth substrate. The incorporation of Triphala in mouth rinse could prove to be effective in reducing S. mutans count in the oral cavity.

Cited by 22 publications

References 20 publications

Therapeutic Uses ofTriphalain Ayurvedic Medicine

Therapeutic Uses ofTriphalain Ayurvedic Medicine

Natural Therapeutic Options in Endodontics - A Review

Antimicrobial effect of herbal extract of Acacia arabica with triphala on the biofilm forming cariogenic microorganisms

Contact Info

Product

Resources

About