Evaluation of Antimicrobial and Synergistic Antimicrobial Properties of Pterocarpus Santalinus

Abstract

Objectives: The aim of the present study was to evaluate antibacterial and synergistic antimicrobial properties of leaf, stem, and bark of Pterocarpus santalinus. Methods:The extraction was done by decoction method. The antimicrobial activity was evaluated by agar well diffusion assay, and the synergistic antimicrobial activity was evaluated by agar disc diffusion assay. Results:The synergistic activity was studied with plant extracts plus antibiotics, namely, ampicillin, polymyxin-B, clotrimazole, and fluconazole. Conclusions:Among the three parts, the best antimicrobial activity was shown by bark extract. All the three parts showed synergistic antimicrobial activity with antibiotics, but their levels varied. The results suggest that all the three parts enhance the antimicrobial efficacy of the antibiotics against some microorganisms and hence can be developed as a new therapeutic weapon against infectious diseases.

Bactenecin and Its Three Improved Derivatives for Enhancement of Antibacterial Activity Against Escherichia coli

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New Insights into Detection of a Dendrobine Compound From a Novel Endophytic Trichoderma longibrachiatum Strain and Its Toxicity Against Phytopathogenic Bacteria

“…In recent years, the change of resistance of bacterial pathogens against natural compounds has become a problematic issue caused by the unselective use of natural compounds. Natural compounds have been called miracle natural active substances, but for more than 60 years of use, the efficacy of current natural active substances has been reduced due to the continuing emergence of natural active substance-resistant bacterial population in wastewater and the adaptations by bacterial pathogens to commonly used antibacterial compounds (Donga et al, 2017). Due to such issues, it is important to explore novel natural compounds, which have the ability to show effective antibacterial activity.…”

Best from Waste: Therapeutic Potential of Plant Waste (Seeds, Peels, Flowers)

“…Plants show various biological activities viz. antioxidant (Punica granatum -Kaneria et al, 2012), hepatoprotective (Abelmoschus moschatus - Singh et al, 2012), anticancer and antimicrobial and synergistic antimicrobial (Pterocarpus santalinus - Donga et al, 2017aDonga et al, , 2017b, antioxidant and anti-inflammatory (Moringa oleifera - Xu et al, 2019), anti-ulcer (Nigella sativa -Paseban et al, 2020, antiurolithiatic (Mangifera indica -Iman et al, 2020) etc. The therapeutic property is not isolated to any specific part of the plant.…”