Evaluation of Antimicrobial Activity of the C3f Peptide, a Derivative of Human C3 Protein

Позолотин, В. А.; Umnyakova, Ekaterina S.; Kopeykin, P M; Комлев, А. С.; Dubrovskii, Yaroslav A.; Krenev, Ilia A.; Shamova, Olga; Berlov, Mikhail N.

doi:10.1134/s1068162021030158

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Carboxyl groups (‐COOH) form covalent bonds with amine or hydroxyl groups on micromolecular‐opsonins such as IgG and participate in electrostatic interactions 16 . Hydroxyl groups (‐OH) are present on many nanoparticles and are involved in the formation of hydrogen bonds with hydroxyl or carbonyl groups on micromolecular‐opsonins such as C3b to facilitate binding and opsonization 17 . Phosphate groups (‐PO 4 ) found on nanoparticulate‐surface interact with calcium ions in the blood to form stable complexes which bind to micromolecular‐opsonins and trigger recognition by immune cells.…”

Section: Introductionmentioning

confidence: 99%

“…16 Hydroxyl groups (-OH) are present on many nanoparticles and are involved in the formation of hydrogen bonds with hydroxyl or carbonyl groups on micromolecular-opsonins such as C3b to facilitate binding and opsonization. 17 Phosphate groups (-PO 4 ) found on nanoparticulate-surface interact with calcium ions in the blood to form stable complexes which bind to micromolecularopsonins and trigger recognition by immune cells. Small-size (100 nm) particles with positive charge (±30 mV) and sufficient hydrophobicity (logP >3) are the ideal target for micromolecules such as albumin, globulins, and so forth.…”

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confidence: 99%

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Evasion of opsonization of macromolecules using novel surface‐modification and biological‐camouflage‐mediated techniques for next‐generation drug delivery

Mehta,

Shende

2023

Cell Biochemistry & Function

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Opsonization plays a pivotal role in hindering controlled drug release from nanoformulations due to macrophage‐mediated nanoparticle destruction. While first and second‐generation delivery systems, such as lipoplexes (50–150 nm) and quantum dots, hold immense potential in revolutionizing disease treatment through spatiotemporal controlled drug delivery, their therapeutic efficacy is restricted by the selective labeling of nanoparticles for uptake by reticuloendothelial system and mononuclear phagocyte system via various molecular forces, such as electrostatic, hydrophobic, and van der Waals bonds. This review article presents novel insights into surface‐modification techniques utilizing macromolecule‐mediated approaches, including PEGylation, di‐block copolymerization, and multi‐block polymerization. These techniques induce stealth properties by generating steric forces to repel micromolecular‐opsonins, such as fibrinogen, thereby mitigating opsonization effects. Moreover, advanced biological methods, like cellular hitchhiking and dysopsonic protein adsorption, are highlighted for their potential to induce biological camouflage by adsorbing onto the nanoparticulate surface, leading to immune escape. These significant findings pave the way for the development of long‐circulating next‐generation nanoplatforms capable of delivering superior therapy to patients. Future integration of artificial intelligence‐based algorithms, integrated with nanoparticle properties such as shape, size, and surface chemistry, can aid in elucidating nanoparticulate‐surface morphology and predicting interactions with the immune system, providing valuable insights into the probable path of opsonization.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Evasion of opsonization of macromolecules using novel surface‐modification and biological‐camouflage‐mediated techniques for next‐generation drug delivery

Mehta,

Shende

2023

Cell Biochemistry & Function

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Antimicrobial activity of the complement system

Egorova,

Krenev,

Oborin

et al. 2023

Medical academic journal

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The complement system plays a key role in homeostasis and defense against pathogens. The antimicrobial activity of serum against Gram-negative bacteria is usually attributed to the action of the membrane attack complex. However, there is increasing evidence that some other components of the complement system and the products of its activation are also capable of direct killing of both Gram-negative and Gram-positive bacteria. In the course of complement activation, anaphylatoxins C3a, C4a, C5a are produced, which, in addition to their main function, can exhibit a bactericidal effect and disrupt the bacterial membrane. Recent studies have shown that in fish, complement factors D, I, as well as a Ba fragment of factor B, are able to neutralize pathogens. The triggering and amplification of complement usually occurs on the surface of pathogen cells, so the local production of antimicrobial components can potentially make a significant contribution to their elimination. The aim of this review is to outline the role of individual complement members in the elimination of pathogens through direct antibiotic action. The problem of antimicrobial protection in the context of therapeutic complement inhibition is considered.

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Evaluation of Antimicrobial Activity of the C3f Peptide, a Derivative of Human C3 Protein

Cited by 2 publications

References 33 publications

Evasion of opsonization of macromolecules using novel surface‐modification and biological‐camouflage‐mediated techniques for next‐generation drug delivery

Evasion of opsonization of macromolecules using novel surface‐modification and biological‐camouflage‐mediated techniques for next‐generation drug delivery

Antimicrobial activity of the complement system

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